150 results about "Aminoglycoside Agents" patented technology

The invention pertains to pharmaceutical compositions of Zosyn® piperacillin with tazobactam in the presence of a buffer, preferably citrate, a particulate formation inhibitor, preferably EDTA optionally an aminoglycoside which when frozen and thawed or lyophilized and reconstituted reform a solution which has decreased particulate formation.

A pharmaceutical composition comprising: at least one aminoglycoside antibiotic and (a) at least one ion chelating agent used for inhibiting particulate formation, or (b) at least one buffer, or (c) at least one ion chelating agents and at least one buffer simultaneously. The composition for use in controlling microbial infection can be formulated into a solution, or combined with at least one beta-lactam antibiotic, or combined with at least one of beta-lactam antibiotic and at least one beta-lactamase inhibitor into a solution in a container.

A novel group of aminoglycosides which share some structural features of currently available aminoglycosides with regard to the backbone, while also having significant structural differences. The similarity enables these aminoglycosides to be highly potent and effective antibiotics, while the significant differences enable these aminoglycosides to reduce or even block antibiotic resistance.

The present invention relates to the use of a combination of nordihydroguaiaretic acid and an aminoglycoside for treating a microbial infection or for killing clinically latent microorganisms associated with microbial infections.

A series of novel derivatives of micronomycin, its preparing process and the medicines containing them as active component are disclosed. The said derivatives are prepared through alkylating and acylating C1-NH2 of microromycin and chemical reactions. Its advantage is high antibacterial activity.

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I):

including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q₁, Q₂, Z₁, Z₂, Z₃, Z₄, R₁, R₂ and R₃ are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

The invention features methods of treating a inherited or acquired cutaneous or gastrointestinal (GI) disorder caused by or having a symptom caused by a nonsense mutation by local administration of a nonsense suppressor agent (e.g., an aminoglycoside or nucleic acid encoding a suppressor tRNA) to the skin or intraluminal GI surface so as to provide for phenotypic suppression of the nonsense mutation.

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I):

including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q₁, Q₂, Q₃, R₈ and R₉ are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I):

including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q₁, Q₂, R₁, R₂ and R₃ are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I):

including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Q₁ and Q₂ are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I):

including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q₁, Q₂, Q₃, R₁, R₂ and R₃ are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I) or (II):

including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q₁, Q₂, Q₃, R₁, R₂ and R₃ are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I):

including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q₁, Q₂, R₁, R₂ and R₃ are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I) or (II):

including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q₁, Q₂, Q₃, R₁, R₂, R₃, R₁₁ are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

The present invention relates to method for obtaining optimum expressed proteins in a transformed gram positive bacteria by specific integration of T7 RNA polymerase gene into the chromosome of a gram positive bacteria exhibiting resistance to aminoglycosides, said method comprising:- digesting an E. coli plasmid with a restriction enzyme- digesting the genomic DNA of said gram positive bacteria- ligating the said digested plasmid to the digested genomic DNA of said gram positive bacteria- transforming the said gram positive bacteria protoplasts with the said ligation mixture of step 2 to yield transformed gram positive bacteria (transformants),- screening the said transformants for kanamycin resistance and aminoglycoside sensitivity to ensure that the targetting of the said plasmid vector into the chromosome of the said gram positive bacteria is successful- cloning of the desired gene in the said vector—culturing the transformant in a suitable culture medium- isolating the expressed proteins from the culture medium

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I):

including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q₁, Q₂, R₁, R₂ and R₃ are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I):

including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q₁, Q₂, R₁, R₂, R₃, Z₁ and Z₂ are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle. The method comprises administering to the lungs of the patient a pharmaceutical composition comprising a liposomal complexed aminoglycoside comprising a lipid component comprising electrically neutral lipids and an aminoglycoside. Administration comprises aerosolizing the pharmaceutical composition to provide an aerosolized pharmaceutical composition comprising a mixture of free aminoglycoside and liposomal complexed aminoglycoside, and administering the aerosolized pharmaceutical composition via a nebulizer to the lungs of the patient. The methods provided herein result in a change from baseline on the semi-quantitative scale for mycobacterial culture for a treated patient, and/or NTM culture conversion to negative during or after the administration period.

A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.

The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminogylcosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human).

Compositions and methods for reducing and/or preventing antibiotic-related damage to cells of the inner ear and the kidney are provided. Such compositions and methods reduce or prevent hearing loss and kidney damage resulting from use of antibiotics, such as aminoglycoside antibiotics. The composition also find use in reducing or preventing inner ear and kidney damage associated with anti-neoplastic agents, other therapeutic drugs, and environmental factors.