33 results about "Biodegradable nanoparticles" patented technology

The present invention relates to polymeric nanoparticles useful in drug and agent delivery, as well as for imaging, diagnosis and targeting. The polymeric nanoparticles of the present invention comprise polymers and cross-linkers that, when degraded, leave simple nontoxic biocompatible molecules that can be metabolized, excreted, or absorbed by the body. The present invention also relates to processes for producing the polymeric nanoparticles of the present invention, and methods of using them in drug and agent delivery, as well as imaging, diagnosis and targeting.

The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering nucleic acid, DNA, RNA or siRNAs transdermally to an animal subject. The nanoparticles are composed of positively charged chitosan substrate and the nucleic acid encapsulated within the nanoparticles or electrostatically loaded on the exterior surface of the nanoparticles.

This invention provides a method of modifying a cellular response in a mammal. The method comprises administering to the mammal an effective amount of biodegradable nanoparticles, each of said nanoparticles comprising an active agent, a biodegradable polymer, and a bone targeting agent administering to a mammal an effective amount of a composition comprising a compound absorbed in a biodegradable nanoparticle which is attached to a bone targeting agent. The invention also provides a method for modifying a cellular response in a mammalian cell comprising contacting the mammalian cell with biodegradable nanoparticles. The invention further provides a method of delivering an exogenous substance to a mammal. The method comprises administering to the mammal a composition comprising the exogenous substance absorbed into a biodegradable nanoparticle, wherein the biodegradable nanoparticle is covalently attached to a bone targeting agent. The invention also provides a composition and a process for preparing the composition comprising a biologically active or therapeutic agent of compound, a biodegradable nanoparticle, and a bone targeting agent.

The invention discloses a biodegradable nanoparticle-entrapped oral colon-targeted micro-capsule and a preparation method thereof. The preparation method comprises the following steps: 1, dissolving drugs and degradable polymers in an organic phase and taking a solution containing polyvinyl alcohol or sodium cholate as a water phase for preparing drug nanoparticles; 2, dissolving an enteric-coated material in absolute ethanol; 3, dispersing the drug nanoparticles in absolute ethanol in which the enteric-coated material is dissolved; 4, preparing edible oil; 5, dropwise adding ethanol liquid into the edible oil, stirring, solidifying, and volatilizing to remove absolute ethanol; 6, centrifuging suspension liquid, collecting the micro-capsule in a lower layer, and washing by normal hexane. The prepared oral colon-targeted micro-capsule has a remarkable pH response, drugs in the micro-capsule are hardly released under the acidic conditions, a capsule material is dissolved under the pH value of enteric canal, the drug nanoparticles are released, the nanoparticles can be transferred to a target point, and the drugs are slowly released, so that the absorption rate of oral administration is greatly increased, the bioavailability is improved, and the treatment effect is enhanced.

The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering proteins, peptides or siRNAs transdermally to an animal subject. The nanoparticles are composed of positively charged chitosan substrate, negatively charged core substrate complexed with chitosan, and encapsulated bioactive agents.

There are provided compositions and methods for treatment of neurodegeneative diseases and CNS injury. The compositions a pharmaceutically acceptable carrier solution; and a plurality of biodegradable nanoparticles, wherein the nanoparticles comprise a targeting moiety that is able to bind selectively to the surface of a neural stem cell and wherein the nanoparticles further comprise factors such as leukaemia inhibitory factor (LIF); XAV939 and/or one or more of : brain-derived neurotrophic factor (BDNF) or an agonist thereof; epidermal growth factor (EGF) or an agonist thereof; glial cell-derived neurotrophic factor (GDNF) or an agonist thereof; retinoic acid and derivatives thereof; ciliary neurotrophic factor (CTNF) or an agonist thereof; and Wnt5A. The biodegradable nanoparticles may deliver via controlled time release.

Compositions and kits useful for the treatment of myocardial infarction comprise (i) P-selectin-targeted carriers (e.g., P-selectin-targeted liposomes, quantum dots or biodegradable nanoparticles) comprising VEGF and (ii) MSCs.

Disclosed is a method for making and using insoluble, biodegradable, nanoparticles containing the omega-3 fatty acids EPA and DHA in selected ratios. Tests show a surprising effect that the nanoformulation is twice as potent and at least five times more sustained leading to at least tenfold (2×5) higher bioavailability at equal dose (1% v/v).

Use of a polyamino acid as an adjuvant; an application of a polyamino acid as an adjuvant in the production of a vaccine; a vaccine comprising a polyamino acid as an adjuvant; a biodegradable nanoparticle having a virus antigen immobilized thereon; and a vaccine comprising the biodegradable nanoparticle.

Described are new biodegradable nanoparticle platforms for encapsulation and sustained release of protein therapeutics through a scalable and reproducible method. Specifically nanoparticles comprising a complex comprising a protein, or peptide, and a counter ion polymer are described.

A biodegradable material with nanopores and the fabricating method thereof includes steps of providing a polysaccharide polymer; implanting multiple biodegradable nanoparticles on the polysaccharide polymer; and digesting those biodegradable nanoparticles through multiple enzymes to provide multiple nanopores on the polysaccharide polymer; the polysaccharide polymer being further implanted with a group of nano-grade electrically conductive material; and the biodegradable material with nanopores simultaneously providing advantages of biocompatibility, biodegradability, elasticity, retarded elasticity, porosity, and conductivity.