Biodegradable hydrogels for tissue repair with temperature-controlled release of nano-hydroxyapatite

Abstract

The invention relates to the technical field of biomedical materials, in particular to a biodegradable hydrogel for promoting tissue repair and releasing nano-hydroxyapatite under temperature control. The biodegradable hydrogel for promoting tissue repair with temperature-controlled release of nano-hydroxyapatite provided by the present invention includes biodegradable nanoparticles, nano-particle cores, nano-hydroxyapatite particles and α-cyclodextrin. On the one hand, degradable nanoparticles achieve rapid repair and reconstruction of tumor postoperative defects through the high adhesion of dopamine to tissues; on the other hand, nHA is dispersed in the nanoparticle solution, and the The host-guest interaction between polyethylene glycol monomethyl ether in the shell constructs a biodegradable hydrogel with uniform dispersion of nHA, and utilizes the photothermal effect of the photothermal agent and the dual effect of nHA to inhibit tumor proliferation to achieve efficient treatment of tumors.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a biodegradable hydrogel that promotes tissue repair by releasing nano-hydroxyapatite under temperature control. Background technique [0002] Tissue repair and reconstruction after tumor surgery and tumor cure are a major clinical challenge. Biodegradable hydrogels have broad application prospects in many fields such as skin repair, wound dressing, and wound suture. [0003] In the application process, most of the existing hydrogels used for tissue repair lack tissue adhesion and cell affinity. For example, Chinese patent application CN105853252A discloses a thermosensitive hydrogel for skin thermal damage, which can sustainably Cooling, sufficient water carrying capacity without dripping water, more flexible use area and position, can improve inflammation, burning, tightness, pain and other discomfort, and can promote skin repair, however, the temperature-sensitiv...

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Problems solved by technology

[0004] Chinese patent CN104306325B discloses a method for preparing an anti-tumor hydrogel. The anti-tumor hydrogel prepared by this method uses sericin and gelatin as the matrix, disperses graphene oxide loaded with doxorubicin in it, and uses pentadiene Aldehyde is a cross-linking agent. By controlling the concentration of sericin, the release rate of doxorubicin can be efficiently regulated, and a good anti-tumor effect can be achieved. However, doxorubicin is a commonly used drug for treating tumors. Toxins remain in the body, resulting in adverse symptoms

Nano-hydroxyapatite (nHA) has a good effect on apoptosis or inhibiting tumor cell proliferation without toxicity. However, the release of nHA through the degradation of traditional hydrogel is slow and uncontrollable. Recurrence, but it is difficult to achieve a complete cure of the tumor

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