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Metal complexes incorporated within biodegradable nanoparticles and their use

A technology of metal complexes and nanoparticles, which can be used in nanomedicine, nanotechnology, nanotechnology, etc., and can solve problems such as slow absorption

Inactive Publication Date: 2010-11-17
THE UNIVERSITY OF AKRON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

A disadvantage of the drug is its hydrophobic nature, which results in slow absorption of the drug in the body

Method used

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  • Metal complexes incorporated within biodegradable nanoparticles and their use
  • Metal complexes incorporated within biodegradable nanoparticles and their use
  • Metal complexes incorporated within biodegradable nanoparticles and their use

Examples

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Embodiment Construction

[0075] Disclosed herein is the use of biodegradable nanoparticles-linked metal compounds, including metal complexes, in antimicrobial applications, including the treatment of bacterial and fungal infections. More specifically, the present invention includes, but is not limited to, silver(I) metal complexes, silver(I) macrocyclic metal complexes, and silver(I)N as simple salts incorporated into these biodegradable nanoparticles. -Heterocyclic carbenes (NHCs) for antimicrobial applications including, for example, the treatment of bacterial and fungal infections.

[0076] Delivery of therapeutic agents, such as proteins and DNA, to the lung via the pulmonary pathway shows great potential for the treatment of a variety of genetic and acquired diseases, such as asthma, cystic fibrosis, and lung cancer. Aerosol inhalation via methods such as spraying provides an easy and non-invasive route to achieve the target. However, these drugs are not amenable to conventional means of deliver...

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Abstract

Compounds for antimicrobial applications, and for treating bacterial and fungal infections are set forth. The compounds may include a metal complex incorporated into a biodegradable polymeric nanoparticle. Also, a method of treating bacterial and fungal infections in a mammal includes the steps of administering an effective amount of a silver(I) metal salt incorporated into a biodegradable polymeric nanoparticle.

Description

[0001] Cross-References to Related Applications [0002] This international patent application claims priority and benefit to US Provisional Application No. 60 / 951,297, filed July 23, 2007, which is incorporated herein by reference. technical field [0003] The present invention relates to metal complexes useful in the treatment of bacterial and fungal infections. More particularly, the present invention relates to metal complexes incorporated into biodegradable substances for the treatment of bacterial and fungal infections. Even more particularly, the present invention relates to metal complexes incorporated into biodegradable nanoparticles for the treatment of bacterial and fungal infections. Background of the invention [0004] Silver has long been used for its antimicrobial properties. This application precedes scientific or medical understanding of its mechanism. For example, the ancient Greeks and Romans used silver coins to maintain the purity of water. Today, si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61K9/14A61K33/38A61K9/16A61P31/04
CPCA61K47/48915A61K47/48907A61K33/38B82Y5/00A61K9/5146A61K9/5153A61K31/65A61K47/6935A61K47/6937A61P31/04A61P31/10Y02A50/30
Inventor W·J·扬斯K·M·欣迪D·A·梅维茨M·潘茨纳C·泰西耶
Owner THE UNIVERSITY OF AKRON
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