6 results about "Cns injury" patented technology

The invention discloses application of a group of blood nutrition markers in prediction of central nervous system (CNS) injury function prognosis. According to the technical scheme, the method is characterized in that serum albumin, total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) are determined as independent predictive factors of CNS injury prognosis for the first time through retrospective queue research (n = 404), and clinical decision critical values are determined to be 36.35 g / L, 3.60 mmol / L and 2.13 mmol / L respectively. The detection kit developed on the basis of the discovery can objectively and quantitatively evaluate the prognosis risk of the patient within 24 hours of admission, and is obviously superior to that of a traditional scoring system. According to the method, key technical support is provided for precise nutrition intervention and early rehabilitation strategy formulation of the CNS injury.

The invention provides a traditional Chinese medicine external application composition for treating gastroparesis after brain injury and a preparation method thereof. The traditional Chinese medicine external application composition is prepared from the following components: rhizoma acori graminei, paederia scandens, radix polygoni multiflori preparata, aloe, gastrodia elata, semen aesculi, phyllanthus emblica, stephania tetrandra, turmeric, radix fici simplicissimae, fructus piperis longi, swertia pseudochinensis, rhizoma nardostachyos, lily, ginkgo leaves and cynanchum paniculatum. Dual mechanisms of neuroprotection and gastrointestinal motility regulation are creatively fused, central nervous injury can be improved through components such as rhizoma acori graminei and radix polygoni multiflori preparata, gastrointestinal hormone secretion and slow-wave pace-making functions can be synchronously regulated through components such as paederia scandens and turmeric, and compared with a conventional single-target treatment means, the traditional Chinese medicine composition is more suitable for a complex pathological mechanism of gastric paralysis after brain injury. Meanwhile, the preparation process is simple, the cost is low, external application avoids aggravation of gastrointestinal burdens, common western medicine side effects such as arrhythmia are avoided, clinical operation is convenient, patient tolerance is good, the gastric emptying recovery time is remarkably shortened, and the risk of complications such as aspiration pneumonia is reduced.

The invention discloses application of a deubiquitinating enzyme inhibitor and an OTUD7A-HINT1-mTOR axis in regeneration of a central nervous system, and belongs to the technical field of biology. The technical problem to be solved by the invention is how to promote the regeneration of the central nervous system. The invention finds that the deubiquitinating enzyme inhibitor PR-619 can promote the growth of axons in neuron cultures and retina explants, protect the survival of RGCs and enhance the regeneration of axons after ONC. The PR-619 can also promote CNS regeneration by down-regulating expression of HINT1, HINT is one of main targets of the PR-619 and plays a role through an mTOR signal channel, and OTUD7A serves as an upstream regulation factor of the HINT1. The PR-619 can be used for treating the CNS injury, the OTUD7A-HINT1-mTOR axis can be used as a CNS injury treatment target, and the PR-619 and the OTUD7A-HINT1-mTOR axis can be combined for treating the CNS injury.

The invention discloses injectable temperature-sensitive hydrogel as well as a preparation method and application thereof, and belongs to the technical field of hydrogel. The preparation method comprises the following steps: dissolving silk fibroin and beta-cyclodextrin in water, and carrying out cross-linking reaction on the silk fibroin and the beta-cyclodextrin to obtain a silk fibroin-beta-cyclodextrin solution; n-isopropylacrylamide monomer powder is added into the silk fibroin-beta-cyclodextrin solution, then a photoinitiator is added, ultraviolet irradiation is carried out, so that N-isopropylacrylamide is subjected to photopolymerization to form poly (N-isopropylacrylamide), poly (N-isopropylacrylamide) and silk fibroin-beta-cyclodextrin form a double-cross-linked network, and the temperature-sensitive hydrogel is obtained. The temperature-sensitive hydrogel is relatively low in viscosity at normal temperature, has injectability, and can be rapidly cured at about 35 DEG C. Experiments prove that the temperature-sensitive hydrogel has good biocompatibility, can be used as a drug release system, and can also be used for loading cells. Meanwhile, the silk fibroin is a material with a tissue repair function, so that the temperature-sensitive hydrogel has huge application potential in the aspect of central nervous injury repair.

This invention discloses a material-empowered stem cell-derived exosome, its preparation method, and its application, belonging to the field of biomedical technology. The method involves the following steps: mesenchymal stem cells are seeded onto a substrate fused with N / VE-cadherin-Fc fusion protein and cultured to assemble into aggregates; the aggregates are dynamically cultured under staged shear stress; the culture medium is collected, and the exosomes are separated and purified. The preparation method of this invention overcomes the shortcomings of existing mesenchymal stem cell exosome preparation technologies, such as low yield and insufficient neurovascular repair function. It significantly activates exosome biogenesis-related molecular pathways, increases exosome yield by approximately four times, and is rich in miRNAs related to neurovascular repair. It can significantly improve neurological deficits in stroke mice and hindlimb motor function in rats with spinal cord injury, providing a highly efficient and stable cell-free therapeutic strategy for the treatment of central nervous system injuries.

The invention relates to the technical field of hand rehabilitation training, and discloses a training method and system based on a hand rehabilitation exercise device for a patient with central nervous injury, and the system comprises a to-be-used hand rehabilitation exercise device and a control device; the control device is connected with the hand rehabilitation exercise device to be used; the acquisition module is configured to determine initial training parameters of the hand rehabilitation exercise device to be used based on the recovery stage information and the physical condition information; the judgment module is configured to judge whether the initial training parameters are adjusted or not according to the rehabilitation indexes; the adjustment module is configured to determine an adjustment coefficient of the initial training parameter based on the analysis result and obtain a final training parameter; the early warning module is configured to judge whether motion errors occur or not based on the face information; if yes, collecting hand pressing information of the patient to be recovered, and determining the motion error level based on the hand pressing information. Training is more suitable for the actual situation of a patient, and the rehabilitation effect is improved.