115 results about "Hindlimb" patented technology

A robotic system and method for locomotion assessment and training of a mammal, exemplified by a rodent. A neurologically impaired animal is suspended over a moving surface in a harness, and the animal's hindlimbs are connected to robotic arms that apply force to the hindlimbs or measure limb movement characteristics. The moving surface can be a physical or virtual surface. A single robotic mechanism comprising two robotic arms can simultaneously apply force, measure limb movement, and provide a virtual surface. Manual or automatic adjustment of load support allows the mammal to step at varying body weight loads.

The invention provides a frog-inspired biomimetic jumping robot. Forelimb and hindlimb driving mechanisms are mounted on a body mounting plate and connected with forelimb and hindlimb actuating mechanisms respectively, each of the forelimb driving mechanism and the hindlimb driving mechanism comprises an input shaft, a second gear, a one-way bearing, an incomplete gear and a ratchet pawl are mounted on each input shaft, each second gear is in gear transmission with a second output shaft, each incomplete gear is in gear transmission with a first output shaft, ropes are wound on second winding drums which are mounted at two ends of each first output shaft respectively, and output gears are mounted at two ends of each second output shaft respectively. By means of reasonable arrangement of the forelimb and hindlimb driving mechanisms and the forelimb and hindlimb actuating mechanisms, utilization rate of driving elements of the robot is increased, mechanical structures of legs are optimized, biomimetic degree of the robot is increased, jumping capability of the robot is enhanced, flexibility of mechanical mechanisms of the robot is improved, and posture stability during jumping is improved.

A robotic limb structure which is capable of achieving high speeds. In the context of a biped, the structure is used for a pair of hind limbs. The limb structure includes a primary driven link—such as a thigh pivoting about a hip joint in the case of a hind limb. Secondary links are pivotally connected to the primary driving link. Auxiliary links are provided to constrain the motion between the links. Elastic trim elements are also provided to define a “relaxed” state for the limb and to influence the resonance characteristics of the structure. The control system takes advantage of the resonant characteristics of the structure as a whole.

The invention discloses a multi-function animal weight-losing running table and a control system thereof. The running table comprises a running machine, a weight-losing support device and a recovery robot. Running training or combination training of running training and electric stimulus is performed on the experimental animal by arranging organic glass and a stimulating electrode on the running machine; and the weight-losing running table training combining running table training and weight-losing support is performed on the experimental animal by arranging the weight-losing support device on the running machine. In the process of weight-losing running table training, the recovery robot can assist hind legs of the experimental animal in doing exercise training, so that a correct or preset training task is provided for a passive training model, the movement locus of the hind legs in the positive training model is recorded and the record is used for quantitatively evaluating the exercising function. The invention also provides a medicinal animal experiment device which is mainly used for walking function recovery of the experimental animal with hurt spinal cord and providing the animal running table training needed by sports medicine.

The invention discloses a bionic mechanical leg imitating the motion function characteristic of an ostrich hind limb. The mechanical leg comprises a body, a hip joint motion mechanism, a knee joint motion mechanism and an ankle joint motion mechanism. The hip joint motion mechanism is composed of a motor and a crank-rocker mechanism, wherein the crank-rocker mechanism comprises a crank, a femur and a connecting rod. The knee joint motion mechanism comprises the femur, a first spring, a tibia, a metatarsus, a brake cable, a lower fibula, a second spring, an air cylinder and an upper fibula. The ankle joint motion mechanism comprises the metatarsus, a first apotelus bone, a second apotelus bone, a third apotelus bone, a third torsional spring, a second torsional spring and a first torsional spring. The ostrich hind limb capable of efficiently moving serves as the bionic prototype, through combination of testing on hind limb motion parameters during running of an ostrich and biological anatomic analysis, the mechanical leg imitating the ostrich hind limb is obtained through optimization design according to the tendon-bone and muscle-tendon interaction mechanism of the ostrich, and the mechanical leg is simple in structure, safe, reliable, low in vibration, and capable of efficiently saving energy.

The invention discloses an application of lnc (long non-coding) RNA lnc-DIF. The technical scheme is that a femur sample of an old osteoporotic mouse model and a femur sample of a hindlimb-unloaded osteoporotic mouse model are detected firstly, and high expression of the lnc RNA lnc-DIF in bone tissue of the old and hindlimb-unloaded osteoporotic mouse models is discovered. An RNA interference sequence of the lnc RNA lnc-DIF is further designed and prepared, osteogenic differentiation function experiments discover that the lnc RNA lnc-DIF inhibits osteogenic cell differentiation and can be specifically bound to osteogenesis related miR-489-3p. Accordingly, the lnc RNA lnc-DIF can be used for preparing drugs for treating osteoporosis caused by various factors as well as other diseases of a skeletal system.

The invention discloses a tail-suspended rat fixing device, which comprises a rat fixing box, a tail suspension device and an angle adjusting device. The invention also provides a tail-suspended rat vibration/motion training device, which comprises a motion track limit device, a vibration training device, an active motion training device, a passive motion training device, a rat hind limb fixing device and a height adjusting device. The invention also provides a vibration/motion control device, which comprises a display screen, a key, a direct-current motor speed adjusting knob, a power supply adapter, a switch, a USB interface and an internal circuit, wherein the direct-current motor speed adjusting knob is used for adjusting the rotating speed of a direct-current motor during passive motion training; the power supply adapter and the switch are used for supplying power for the whole device; the USB interface is used for carrying out function expansion later; and the internal circuit is used for controlling and quantifying rat vibration/motion training and supplying power. The device can keep the same tail-suspended height, can carry out equal-length and equal-tension motion by combining vibration and motion training, and simultaneously achieves training quantification and control.

The invention discloses an energy-saving walking leg mechanism simulating ostrich hindlimb movement function characteristic. The energy-saving walking leg mechanism comprises a rack, a crank connection rod mechanism, a rebounding mechanism and a toe, wherein the crank connection rod mechanism comprises a crank, a thigh and a rocking rod; the rebounding mechanism comprises a fixed sliding block, a crus, a movable sliding block, a connection rod, a spring, a baffle plate, a ratchet mechanism, a brake cable, an angle limiter and metatarsal bones. The energy-saving walking leg mechanism is designed on the basis of the size parameters of the ostrich hindlimb and the rebounding characteristics of joints between ostrich tarsal bones; an energy-saving and efficient walking leg is designed by simulating the ostrich hindlimb movement; the metatarsal bones automatically stretch by using the rebounding force generated by compressing the spring, so that the energy loss is reduced; the energy-saving and efficient walking leg simulating ostrich hindlimb movement function characteristic can achieve the energy-saving and efficient purpose.

The invention provides a pneumatic-muscles-based robot hind limb simulating a cheetah. The structure of the robot hind limb comprises a hip unit 1, a thigh unit 2, a shin unit 3 and a foot unit 4, wherein the hip unit 1, the thigh unit and the shin unit respectively comprise a diaphysis and joint parts. The overall robot hind limb adopts a structural form that the diaphysis is placed inside and pneumatic muscles are placed outside to package the periphery of the diaphysis, the structural form is similar to the real body structure of an organism and approaches to a force-exerting form of the cheetah hind limb. The joint of the robot hind limb passes through a connector of upper and lower diaphyses by a connecting shaft and is supported by a rolling bearing; and one end of the connecting shaft extends out of the bearing to be connected with an angle sensor so as to obtain joint angle-rotating information and provide data for motion control. The joint ensures that linear force of the muscles is converted to rotating torque of the joint in a form of pulling (in opposite directions) of pneumatic muscles, and the rigidity is adjustable.

A device allowing a quadruped animal that is disabled in the hindquarters thereof to move about, while automatically moving the hind legs of the animal. The device includes: a chassis, on which two side wheels are mounted; a rear harness for receiving and supporting the hindquarters of the animal, which harness can be supported by the chassis; a crankshaft-type driveshaft having two crankpins to which are attached means for moving the hind legs of the animal, said driveshaft being shaped so as to move each of the two hind legs of the animal synchronously in phase opposition like the movement of a chainset; and a transmission for controlling the rotation of the driveshaft from at least one wheel.

The invention discloses a novel EV71 virus strain of which the whole-genome length is 7405bp and the sequence is shown in SEQID NO:1. The virus strain can infect ICR, KM, BALB/c and NIH mice; the virus dosage of larger than 1*10<2>-1*10<7> TCID50 can cause the disease attack or death of 1-17 days mice; the administration route can be intraperitoneal injection, encephalocoele injection and intragastric administration; the symptoms are typical symptoms of EV71 virus infection and are divided into the following five levels according to stages of the disease: Level 0: not attacked; L1: motion incoordination and weakness of limbs; L2: hypokinesia and paralysis of fore or posterior limbs; L3: quadriplegia and dying; and L4: death. Various animal evaluation models such as an immunogenicity animal evaluation model of hand-foot-and-mouth disease vaccine and an animal evaluation model of EV71 therapeutic drug and therapeutic vaccine, can be built conveniently.

The invention provides a method for detecting a special growth and development law of muscles of Jingning chicken. The Jingning chicken are unique and peculiar local chicken of the Gansu province, are fresh and tender in texture and unique in flavor, and have good public praise, however, the Jingning chicken are endangered, and the prospect is grim. In the method for detecting the special growth and development law of the muscles of the Jingning chicken, chick embryos of the Jingning chicken are researched, and special meat quality trait controlling genes such as growth and development gap-associated proteins: CECR2 (cat eye syndrome chromosome region) and IGF-1 (insulinlike growth factor-1), fatty acid metabolism gap-associated proteins: Ex-FABP (fatty acid-binding protein) and LPL (lipoprotein lipase) and protein degradation gap-associated proteins: CAST and CAPN1 are selected. Protein expression distribution and change of expression level of proteins in posterior limb buds and body segments in a chick embryo development HH19-31 period are detected by using methods of immunohistochemistry and Western blotting and the like, and the Jingning chicken are compared to white feather broilers, yellow feather broilers and hyline brown chicken. By the method for detecting the special growth and development law of the muscles of the Jingning chicken, the relation of growth and development regulatory functional genes, growth performance and meat quality is discussed, and data are provided for establishing target genes of transgenic chicken. Moreover, the resource superiority can be widely developed and used, and new vitality is injected to development of local economy.

A walking training device for rats with spinal cord injury of which blended leg motion is synchronized with a belt running speed relates to a walking training device for the rats and solves the problems that the prior device for training a hind limb blended leg motion of the rats with the spinal cord injury can not ensure the running speed synchronism of the blended leg motion and the movement slab. Two friction wheels are arranged on the upper end surface of a belt, and the two friction wheel are fixedly installed on a connection plate through a support rod. The connection plate is fixedly installed on a fixing frame. The outer lateral wall of each friction wheel is fixedly connected with one end of a corresponding linkage rod, and the other end of each linkage rod is fixedly connected with the fixing frame. Each linkage rod comprises a first rod and a second rod; one end of the first rod is hinged with one end of the second rod 8-2, and the angle between the first rod and the second rod is 60 degrees to 120 degrees; and the first linkage rod is fixedly connected with the fixing frame. One end of a weight reduction rod passes through the first connection rod to be arranged at the upper side of the belt and fixedly connected with a cylinder, and the other end of the weight reduction rod is provided with a weight; and the angle between the weight reduction rod and the horizontal line is 45 degrees to 60 degrees. The invention is suitable for training the hind limbs of the rats with the spinal cord injury.

The invention belongs to the field of animal medical models and particularly relates to a method for building a small pig model for researches on lower limb deep venous thrombus formation and pulmonary embolism. The method is characterized in that the method comprises the steps of firstly forming small pig posterior limb deep venous thrombus, cutting a small pig anterior limb cephalic vein open for intubation, injecting the in-vitro prepared thrombus into a superior vena cava and delivering the thrombus to a pulmonary artery through cardiac circulation to cause pulmonary artery embolism to build the small pig model for researches on lower limb deep venous thrombus formation and pulmonary embolism, wherein aminomethylbenzoic acid injection in appropriate proportion being 1: (15-20) is added during the preparation of the in-vitro thrombus. By building the small pig model for researches on lower limb deep venous thrombus formation and pulmonary embolism, a good animal model can be provided for pathophysiologic researches on diseases, clinical drug researches and surgical practices. The method provided by the invention has the advantages of simple anesthesia operation, clear effect, simple and rapid surgical operation, high pulmonary embolism formation success rate, low fatality rate, convenient inspection means and the like.

A primate restraining device capable of restraining the movement of a monkey and, particularly, capable of facilitating injection or blood drawing. A primate restraining device comprising: a containing body having both side surfaces, a top surface, and a bottom surface; a door provided to the rear surface side of the containing body and capable of opening and closing the rear surface side of the containing body by sliding up and down; and a partition wall which is formed so as to close the inside of the containing body from the front surface side and to be movable forward and backward within the containing body and which is configured to be able to be affixed at a desired position within the containing body. The partition wall has provided therein hind-limb protrusion openings from which the hind limbs of the contained primate are caused to protrude to the outside.

The invention discloses lncRNA OGRU and drug use of an lncRNA OGRU overexpression vector. The expression of the lncRNA OGRU in a 2D rotation MC3T3-E1 cell de-load model and a mouse hind limb unweighted (HLU) de-load model is significantly reduced, the OGRU overexpression vector pcDNA3.1(+)-OGRU promotes cell differentiation of mouse preosteoblast MC3T3-E1 in the 2D rotation MC3T3-E1 cell de-load model, and pcDNA3.1(+)-OGRU is delivered to a mouse osteogenesis area by a bone targeted delivery system (DSS) 6-liposome to effectively relieve osteoporosis caused by HLU; and OGRU has potential to become a new target for disuse osteoporosis diagnosis biomarkers and treatment, and the OGRU overexpression vector is used in drugs for treating the disuse osteoporosis.

The invention relates to a remote control bulldog clamp used in a laparoscopic surgery. The remote control bulldog clamp is characterized by comprising a clamp body, wherein one end of the clamp body is two front limbs closed in a normal state, and the other end of the clamp body is a back limb for operating the two front limbs to open; an oval space is defined when the two front limbs are closed, and the short diameter of the oval space is matched with the diameter of the renal artery; the inner surface of each front limb is provided with a water bag, the sum of the diameters of the two water bags filled with liquid is larger than the diameter of the renal artery, and the water bags filled with the liquid can push the two front limbs to open towards the two sides; the water bags are connected with a puncture needle through a thin plastic guiding pipe in the process of puncturing, and are connected with a water pump provided with an adjusting knob in the process of water injection; the diameter of each water bag filled with the liquid is controlled by operating the adjusting knob. Compared with the prior art, the remote control bulldog clamp has the advantages that the artery is blocked and opened while a doctor does not stop cutting, and warm ischemia time of the organs is shortened to the maximum extent.

The invention discloses a training device and a training method. The training device comprises a forelimb movement mechanism, a posterior limb movement mechanism, a linkage mechanism, a middle supporting mechanism and an inclination mechanism. The forelimb movement mechanism is installed on the tilting mechanism, the posterior limb movement mechanism is installed on the tilting mechanism, the linkage mechanism is connected with the forelimb movement mechanism and the posterior limb movement mechanism, the middle supporting mechanism is installed on the tilting mechanism, and the linkage mechanism is installed on the middle supporting mechanism. According to the training device, the comfort degree of a patient during crawling is greatly improved, and the crawling posture is corrected.

The invention provides a constructing method of a femur middle-lower section bone defect model. The constructing method of the bone defect model comprises the following steps: (1) taking preserved skin from posterior limb of an anesthetized animal and disinfecting the preserved skin, and making incisions on middle, lower and front outer sides of femur of the animal to expose the middle-lower section of the femur; and (2) exciding femurs differing in size from the middle-lower section of the femur to form bone defect, irrigating wounds, dressing and stitching so as to obtain the femur middle-lower section bone defect model. On a femur middle-lower section bone defect operative approach, important blood vessels and nerves are avoided, so that secondary injury and bleeding are relieved in a process of establishing the bone defect model to the greatest extent; and the model is good in unity and repeatability, and is conducive to simulating a clinical bone defect repairing effect. The invention also provides a femur middle-lower section bone defect model prepared based on the method and application of the bone defect model.