15 results about "Insulinlike growth factor" patented technology

The invention provides an application of bifidobacterium animalis subsp. Lactis CP-9 in preparation of a product for promoting bone growth and development or improving bone health. Long-term research and a large number of experiments show that the bifidobacterium animalis subsp. Lactis CP-9 can improve the bone volume fraction, the bone trabecula thickness, the bone density and the bone volume of an organism, and can also effectively improve the growth hormone level and the insulin-like growth factor 1 level, so that bone growth and development are promoted. Meanwhile, the bifidobacterium animalis subsp. Lactis CP-9 can effectively improve the N-terminal propeptide level, osteocalcin level, bone morphogenetic protein level and osteoprotectin level of I-type procollagen in a body, and remarkably reduce the amino-terminal peptide level of the I-type collagen and the ligand level of nuclear factor kappa B receptor activating factor, so that osteoblast differentiation is promoted, osteoclast differentiation is inhibited, and osteoclast differentiation is inhibited. Furthermore, bone formation is promoted, bone resorption is inhibited, bone metabolism is improved, and finally the effect of improving bone health is achieved.

The present invention provides methods and compositions for the treatment of chronic lung disease (CLD), comprising administering to a subject in need of treatment a composition comprising insulin-like growth factor-1 (IGF-1).

The invention belongs to the technical field of experimental animal nutriology and sterile animal culture, and particularly relates to a vitamin compound for prolonging the survival time of sterile zebra fish and a preparation method of the vitamin compound. The vitamin compound is prepared from the following components in parts by mass: 600 to 1000 parts of vitamin A, 4000 to 6000 parts of vitamin C, 10 to 30 parts of vitamin D3, 1500 to 2200 parts of vitamin E, 80 to 120 parts of vitamin K3, 15000 to 25000 parts of compound B vitamins and sterile culture water. The preparation method comprises the following steps: dissolving the vitamin raw materials in sterile culture water, performing ultrasonic assisted dissolution, and then filtering and sterilizing to obtain the vitamin supplement. When the vitamin supplement is used for feeding the sterile zebra fish, the survival time of the sterile zebra fish can be obviously prolonged, and the expression level of growth hormone genes and insulin-like growth factor genes can be up-regulated. The application value of the sterile zebrafish in scientific research is further expanded.

The present invention provides an application of animal Bifidobacterium lactis subspecies CP-9 in the preparation of a product that promotes bone growth and development or improves bone health. After long-term research and a large number of experiments, the present invention found that animal Bifidobacterium lactis subspecies CP-9 can improve the body's bone volume fraction, trabecular thickness, bone density and bone mass, and can also effectively increase the level of growth hormone and insulin-like growth factor 1, thereby promoting bone growth and development. At the same time, animal Bifidobacterium lactis subspecies CP-9 can effectively increase the level of type I procollagen N-terminal propeptide, osteocalcin level, bone morphogenetic protein level, and osteoprotegerin level in the body, and significantly reduce the level of type I collagen amino-terminal peptide and nuclear factor κB receptor activator ligand level, thereby promoting osteoblast differentiation, inhibiting osteoclast differentiation, and then promoting bone formation, inhibiting bone resorption, improving bone metabolism, and ultimately achieving the effect of improving bone health.

The invention discloses a preparation method of a bio-based neural restoration cannula material, and relates to the field of biological materials. The preparation method comprises the following steps: firstly, enabling chitosan, 3-carboxyphenylboronic acid and maleic anhydride to react with nanogold to prepare modified chitosan; acrylic acid, acrylic acid-N-hydroxysuccinimide, alpha-ketoglutaric acid, modified chitosan and glutaraldehyde are subjected to a reaction, hydrogel is prepared, insulin-like growth factor-1 is added, and the bio-based neural restoration cannula is prepared. The prepared bio-based nerve repair sleeve has excellent biocompatibility, antibacterial property and mechanical property, nerves can be effectively repaired without suture, and secondary damage to nerve broken ends is avoided.

The invention relates to the technical field of agricultural science, and particularly discloses preparation and application of a composite polypeptide growth-promoting supplement liquid for livestock and poultry. The composition comprises a plurality of active polypeptides such as recombinant human epidermal growth factors, trefoil peptides, insulin-like growth factors and the like, vitamins A, E, C and B, and is supplemented with recombinant collagen peptides, marine source acidic polysaccharides and a composite carrier consisting of hydroxypropyl-beta-cyclodextrin, trehalose and sodium hyaluronate. The preparation method comprises the following steps: respectively carrying out independent shunt pretreatment on the polypeptide component and the vitamin component, integrating through a programmed gradient compounding process and a dynamic pH regulation process, and finally carrying out fine filtration and sterile filling to obtain the product. The composition can be used for preparing a feed or drinking water additive for promoting the growth of livestock and poultry, maintaining intestinal health and improving the feed utilization rate, and has the advantages of stable components and good activity maintaining effect; according to the preparation method, the long-acting stability of the composite system is realized by optimizing the process sequence and conditions.

In vitro method for producing meat by multiplying non-human fibroblasts, muscle cells, skeletal muscle stem cells and / or myosatellite cells by cultivation in serum-free medium, characterized in that the serum-free medium is free of blood serum and free of albumin, free of ROCK inhibitor, free of pro-inflammatory interleukins (IL), in particular free of IL-6, free of insulin-like growth factor (IGF) and free of vascular endothelial growth factor (VEGF), and the medium contains an inhibitor of the TGFβ signaling pathway which is an inhibitor of Smad2 / 3, and in that the medium contains TGFβ.

Methods are provided for detecting and / or quantifying insulin-like growth factor-2 (IGF-2) variant(s) in a sample. Methods provided herein are further directed to using the detected ion or ions to determine the presence of IGF2 variant(s) in the sample.

The invention discloses a scalp care composition and application thereof. Effective components of the scalp care composition are agilawood extract and tetrahydromethylpyrimidine carboxylic acid or derivatives thereof. Through reasonable compounding of the agilawood extract and the tetrahydromethylpyrimidine carboxylic acid or the derivative thereof, secretion of insulin-like growth factor-1 (IGF-1) is effectively promoted, so that the number of hair follicles is increased, the growth period of the hair follicles is prolonged, the hair follicle health is promoted and / or maintained, and the scalp health can be promoted and / or maintained; the effects of improving or / and preventing alopecia, growing hair, increasing hair density, strengthening hair roots, improving head blood circulation and the like are achieved.

Provided here are methods for treating a cytokine storm in a subject. One such method includes the administration of a therapeutically effective amount of an Insulin-like Growth Factor (IGF-1), a Ca2+-release-activated Ca2+ (CRAC) channel inhibitor, or combinations thereof. Methods include treatment of acute lung injury or acute kidney injury with a therapeutically effective amount of 3,5-bis(trifluoromethyl) pyrazole derivative or teriflunomide, either individually or in combination with IGF-1.

The present invention provides, among other things, methods and compositions for treating Chronic Lung Disease (CLD), comprising administering to a subject in need of treatment a composition comprising insulin-like growth factor-1 (IGF-1) or an agonist or an analog thereof.

The invention discloses a primary tissue or organ-like cryopreservation solution which is prepared from dimethyl sulfoxide, dextran-20, primary cell antibiotics, Penicillin-streptomysin, bovine serum albumin, insulin, transferrin, growth hormone, fibroblast growth factors, human platelet growth factors, bone morphogenetic protein 4, human epidermal growth factors, insulin-like growth factors and the balance of distilled water. The culture medium is prepared from a hepatocyte growth factor, L-glutamic acid, alanine, glycine, L-asparaginic acid, L-proline, serine, sodium pyruvate, glutamine, nicotinamide, N-acetylcysteine, beta-mercaptoethanol, sodium selenite, beta glycerophosphate, cycloastragenol, Y-27632, a DMEM (Dulbecco Modified Eagle Medium) basal culture medium and the like. After the cryopreserved tissue is recovered, the isolated culture of the primary cells can be normally carried out, the viability of the primary cells reaches 93%, and the survival rate of the recovered organoid reaches 92%.

The invention relates to the technical field of biological medicines, and particularly discloses a capsule for promoting gastrointestinal mucosa repair and a preparation method thereof. The capsule for promoting gastrointestinal mucosa repair comprises a capsule core and a capsule skin, the capsule core is prepared from the following components in parts by weight according to the weight of the capsule core: 40 to 60 parts of radix astragali seu hedysari extract, 20 to 30 parts of hericium erinaceus extract, 10 to 20 parts of radix notoginseng extract, 5 to 10 parts of glutamine derivative and 3 to 5 parts of growth factor; the growth factor is a mixture of an insulin-like growth factor and a glial cell-derived neurotrophic factor in a weight ratio of 1: (0.2-0.5); the invention also provides a preparation method of the capsule. The capsule for promoting gastrointestinal mucosa repair provided by the invention can be dissolved and release active ingredients in a specific pH environment of the gastrointestinal tract, so that the gastrointestinal tract is protected, and cell proliferation and gastrointestinal mucosa repair are promoted.