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Production technique and application of follicular cell activator-containing anti-hair loss restoring preparation

A technology for activating factors and hair follicle cells, applied in the field of biomedicine, can solve the problems of insignificant effect, long time, slow onset, etc., and achieve the effect of improving or treating seborrheic alopecia, increasing capillaries, and improving microcirculation.

Inactive Publication Date: 2019-06-21
北京中农创新生物工程研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] The technical problem to be solved by the present invention is: the existing medicine, medical care, beauty care articles for seborrheic alopecia take a long time to take effect slowly, or the effect is not obvious, or the cost is high, etc.

Method used

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  • Production technique and application of follicular cell activator-containing anti-hair loss restoring preparation
  • Production technique and application of follicular cell activator-containing anti-hair loss restoring preparation
  • Production technique and application of follicular cell activator-containing anti-hair loss restoring preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] The preparation of embodiment 1 hair follicle cell activating factor anti-hair loss and growth preparation

[0078]A hair follicle cell activating factor anti-hair loss and growth preparation, which is prepared from the following components in mass percentage:

[0079] Hair follicle cell activating factor 0.005% to 0.1%; mannitol 0.5% to 5%; glycine 1% to 10%; albumin 0.01% to 0.1%; the balance is purified water.

[0080] The preparation method of the above-mentioned hair follicle cell activating factor anti-hair loss and growth preparation comprises:

[0081] Steps to configure cytokine and protein master solution:

[0082] Recombinant human cytokines and recombinant human proteins can be expressed by recombinant Escherichia coli (E.Coli) or other genetic engineering methods, and each cytokine and protein can be obtained through fermentation and purification. The steps are briefly described as follows: Fermentation tank conventional fermentation gene Engineering bact...

Embodiment 2

[0090] The preparation of embodiment 2 solvent

[0091] The solvent is prepared from the following components in mass percent:

[0092] Glycerin 4%-18%; trehalose 1%-10%; hyaluronic acid 0.1%-0.5%; the balance is purified water.

[0093] The solvent preparation steps include:

[0094] Ingredients step: Pour the hyaluronic acid into the mixing tank according to the proportion, add 1 / 3 of purified water, heat to 75-85°C, after dissolving, cool down to 40-50°C to obtain the mixture X;

[0095] Filling step: pour glycerin and trehalose into the mixed solution X, add the remaining purified water, stir evenly, and obtain the mixed solution Y;

[0096] Microfiltration step: filter the mixed solution Y through micropores with a pore size of 0.2-0.3 μm to obtain a solvent.

[0097] The raw materials in the present invention are commercially available pharmaceutical grade or cosmetic grade raw materials.

Embodiment 3

[0098] Example 3 The use of hair follicle cell activating factor anti-hair loss and growth preparation in conjunction with solvent (or purified water)

[0099] After the aforementioned hair follicle cell activating factor anti-hair loss preparation and solvent (or purified water) are prepared respectively, mix and shake the hair follicle cell activating factor anti-hair loss preparation and the solvent (or purified water) before use.

[0100] After the hair follicle cell activating factor anti-hair loss and growth preparation is mixed with a solvent (or purified water), the content of the hair follicle cell activating factor in the mixed solution is 0.002 μg˜100 μg / mL.

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Abstract

The invention relates to a follicular cell activator composition and preparation and their application. A follicular cell activator comprises at least two of a bFGF (basic fibroblast growth factor), an KGF or KGF1 (keratinocyte growth factor or keratinocyte growth factor 1), a KGF2 (keratinocyte growth factor 2), an IGF-1 (insulin-like growth factor 1), a VEGF (vascular endothelial growth factor),an HGF or HGF alpha (hepatocyte growth factor or hepatocyte growth factor alpha), an FGF18 (fibroblast growth factor 18), an SCF (stem cell factor), an FGF20 (fibroblast growth factor 20), an NGF (never growth factor), a GH (growth hormone) and Wnt3a protein. The follicular cell activator preparation herein can regulate proliferation, differentiation, regeneration and metabolism of follicular cells, and improve microcirculation to restore follicles and effectively treat seborrheic alopecia and other types of hair loss.

Description

technical field [0001] The invention relates to a hair follicle cell activating factor, including twelve kinds of recombinant human cytokines and recombinant human proteins. The preparation of this biological preparation and the application of preventing and treating hair loss belong to the field of biomedicine. Background technique [0002] Seborrheic alopecia, also known as androgenetic alopecia (androgenialopecia, AGA), is one of the most common causes of hair loss. It occurs in both sexes, and the incidence rate is very high in the male group. 50% of men will occur when they are 50 years old. Androgenetic alopecia increases to 70% with age. Although seborrheic alopecia has no subjective symptoms, it has a greater psychological impact on alopecia people, and may affect their daily life. With the improvement of living standards, people pay more and more attention to hair loss treatment, and the market demand for hair loss prevention and treatment products is increasing da...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K38/30A61K38/27A61K38/17A61K47/36A61K47/42A61K47/10A61P17/08A61P17/14A61K8/64A61K8/65A61K8/73A61K8/34A61Q7/00A61Q5/02
Inventor 陈永福张国华张曼夫
Owner 北京中农创新生物工程研究院有限公司
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