Spinal cord closed-loop electrical stimulation system

A technology of electric stimulation and electric stimulator, applied in the field of medical equipment for treating spinal cord injury

Active Publication Date: 2019-11-05
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In summary, the existing stimulation systems for animals and patients with spinal cord injury do not use electrical stimulation alone to treat spinal cord injury.

Method used

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  • Spinal cord closed-loop electrical stimulation system
  • Spinal cord closed-loop electrical stimulation system
  • Spinal cord closed-loop electrical stimulation system

Examples

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Embodiment 1

[0037] A mouse spinal cord closed-loop electrical stimulation system of the present invention includes spinal epidural electrical stimulation electrodes, leg electrical stimulation electrodes, closed-loop electrical stimulators, electrical stimulation fixtures and controllers for fixing mice, and controllers Preferably a computer. The spinal epidural electrical stimulation electrode and the leg electrical stimulation electrode are respectively connected to the closed-loop electrical stimulator, the controller is electrically connected to the closed-loop electrical stimulator, and the spinal epidural electrical stimulation electrode is used to implant the subject's L2-L4 nodes Spinal epidural of the spinal cord and applying first electrical stimulation to the spinal epidural, leg electrical stimulation electrodes for implantation in the subject's leg tibialis anterior muscle and applying second electrical stimulation to the leg tibialis anterior muscle, control The device is us...

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Abstract

The invention relates to a spinal cord closed-loop electrical stimulation system, which comprises a spinal epidural electrical stimulation electrode, a leg electrical stimulation electrode, a closed-loop electrical stimulator and a controller, the spinal epidural electrical stimulation electrode and the leg electrical stimulation electrode are respectively connected with the closed-loop electricalstimulator, the controller is electrically connected with the closed-loop electrical stimulator, the spinal epidural electrical stimulation electrode is used to implant the spinal epidural of a subject and to apply a first electrical stimulus to the spinal epidural, the leg electrical stimulation electrode is used to implant the subject's leg and apply to the leg with second electrical stimulus,the first electrical stimulus has a voltage of 400 to 600 mV and a frequency of 10 to 20 Hz, and the second electrical stimulus has the voltage of 1 V to 1.5 V and the frequency of 10 to 20 Hz. The spinal cord closed-loop electrical stimulation system of the present invention can issue an electrophysiological signal similar to a spinal cord sensory-motor neural circuit to the subject after spinalcord injury, the neural circuit can be activated and reshaped after closed-loop electrical stimulation, and the recovery of the motor function of the hind limb of the subject can be promoted.

Description

technical field [0001] The invention relates to the field of medical devices for treating spinal cord injuries, in particular to a spinal cord closed-loop electrical stimulation system. Background technique [0002] After spinal cord injury, the local circuit below the injury site still retains the function of movement. Recent studies have shown that after spinal cord injury, spinal cord epidural electrical stimulation at a specific frequency combined with weight-loss running exercise training can activate the local neural circuit of the spinal cord, thereby Promote the recovery of the motor function of the hind limbs of experimental animals and the lower limbs of patients. However, functional recovery is dependent on electrical stimulation training, and the recovery of motor function is only transient. However, in the existing stimulation training devices, multiple methods are combined to simulate closed-loop stimulation, and there are many influencing factors. At present...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/05A61N1/36A61B5/00A61B5/0488
CPCA61N1/0551A61N1/0558A61N1/05A61N1/36003A61N1/36062A61N1/36153A61N1/36171A61B5/4848A61B2503/40A61B2503/42A61B5/389A61N1/36103A61N1/36139A61B5/407A61B5/395
Inventor 刘耀波杨丹杨维周凯
Owner SUZHOU UNIV
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