10 results about "Seizure disorder" patented technology

The present application provides a kind of potassium channel regulator, its preparation method, pharmaceutical composition and application. Specifically provided are compounds as shown in formula V or pharmaceutically acceptable salts thereof. The potassium channel regulator compound of the present application has one or more of the following effect advantages: (1) novel structure; (2) good KCNQ2 / 3 channel opening activity; (3) weak KCNQ4, KCNQ5 opening activity, high KCNQ2 / 3 selectivity; (4) good in vivo efficacy, good protection effect on seizures; (5) low neuro-motor toxicity; (6) high brain-blood ratio; (7) high plasma, brain tissue concentration.

The present invention relates to oral films containing an active pharmaceutical ingredient (API) capable of providing seizure relief and one or more film-forming polymers, the use of such films, for example for the acute treatment of ongoing seizures, and methods for preparing such films. The film according to the invention is characterized by a rapid dissolution in the buccal cavity followed by a rapid and high systemic absorption.

Systems and method for seizure detection. A seizure detection device utilizes frequency discrimination, time series features, and machine learning clustering algorithms to distinguish between the EEG signal of those experiencing a seizure compared to those who are not experiencing a seizure.

A system for seizure monitoring controls a camera to operate under a monitoring mode to continuously record data from a subject. The system establishes one or more baselines associated with the subject while operating the camera under the monitoring mode. The system detects one or more deviations from the one or more baselines during a first time window. The one or more deviations being associated with an onset of seizure. The system adjusts one or more settings of the camera while operating the camera under the monitoring mode. When the one or more deviations from the one or more baselines persist during a second time window, the system adjusts the camera to operate under a seizure mode.

Devices, systems, and techniques are described that utilize a compact system to detect stroke or seizure. For example, a system includes a memory, a plurality of electrodes, and sensing circuitry configured to sense, via at least two electrodes of the plurality of electrodes, electrical signals from a patient and generate physiological information based on the electrical signals. The system can also include processing circuitry configured to receive the physiological information from the sensing circuitry, determine, based on the physiological information, a seizure metric indicative of a seizure state of the patient and a stroke metric indicative of a stroke state of the patient, and store the seizure metric and the stroke metric in the memory. A housing can carry the plurality of electrodes and contain both the sensing circuitry and the processing circuitry.

The present invention relates to a brain dysfunction and seizure detector monitor and system, and a method of detecting brain dysfunction and / or seizure of a subject. Preferably, the present invention also includes one or more seizure detection algorithms. The analysis method is specifically optimized to amplify abnormal brain activity and minimize normal background activity yielding a seizure index directly related to the current presence of ictal activity in the signal. Additionally, a seizure probability index based on historical values of the aforementioned seizure index, is derived for diagnostic purposes. The seizure probability index quantifies the probability that the patient has exhibited abnormal brain activity since the beginning of the recording. These indexes can be used in the context of emergency and / or clinical situations to assess the status and well-being of a patient's brain, or can be used to automatically administer treatment to stop the seizure before clinical signs appear.

Methods and apparatus for preventing seizure activity in an environment using a computer vision system deployed within the environment are described. One example method includes detecting a seizure trigger within the environment via one or more camera devices deployed in the environment. At least one user associated with the environment that is susceptible to the seizure trigger is identified. Information associated with the seizure trigger is transmitted to a computing device associated with the at least one user.

The present invention relates to the use of cannabidiol (CBD) preparations for use in the treatment of seizures associated with tuberous sclerosis (TSC). [Solution] In particular, the present invention includes the step of administering everolimus in combination with a reduced dose of cannabidiol (CBD). In an alternative embodiment, the present invention relates to the treatment of seizures associated with tuberous sclerosis in everolimus-untreated patients currently treated with CBD. Preferably, the dose of everolimus is reduced by at least 10%.

The application discloses a cross-patient seizure detection method based on a graph-enhanced pulse state space model, first, the brain electrical signal data of a patient is acquired and an electrode space topology graph is constructed; then, a pulse state space model is used to extract the time sequence features of physiological channels, and a pulse graph convolution network is used to perform message aggregation between adjacent nodes in a discrete pulse domain across time steps; finally, feature aggregation is performed through a global average pooling operation at a graph level, and a two-class prediction probability is output through a fully connected classifier. The application follows the design logic of "first time and then space", the pulse state space model models the potential brain state dynamics of the time sequence change, and realizes stable long context feature processing through the cyclic updating mode of the adaptive hardware; the pulse graph neural network completes the information transmission and fusion between channels based on the electrode correlation graph, can capture the spatial dependence relationship which is crucial for the representation of seizures, reduces the calculation energy consumption, and improves the overall performance.

Provided herein are methods for providing an anti-epileptic seizure effect in a subject by administering an effective amount of a compound of formula (I) (also referred to as BAER-101 or AZD7325), in particular (4-amino-8-(2-fluoro-6-methoxy-phenyl)-N-propyl-cinnolin-3-carboxamide). The compounds of formula (I) exhibit efficacy in preventing and reducing epileptic seizures when administered to a subject in need thereof. The method provides a promising method for controlling epileptic seizures and related conditions in a patient, thereby addressing the needs in the field of neurology and pharmaceuticals.