The invention discloses an implantable self-adaptive wireless power transmission system, which includes an external energy transmission module, an internal energy collection module and an adaptive feedback loop; the external energy transmission module includes a power amplification circuit, a signal source and a drive, and a transmission coil ; The power amplifying circuit adopts Class D, and is a voltage switch type; the self-adaptive feedback loop mainly includes in vivo information collection, in vivo and in vitro wireless communication, and in vitro energy control; the entire feedback structure is composed of two loops of in vivo feedback and system feedback circuit structure; the energy harvesting module in the body includes a receiving coil, a coupling capacitor, a full-wave rectification filter, a PWM modulation module, and an LSK modulation circuit. The invention proposes an implantable self-adaptive wireless power transmission system, which can not only meet the uninterrupted power supply requirements of implanted devices, but also make the energy transmission controllable and avoid excessive energy transmission.