A kind of affine projection maximum entropy sub-band adaptive echo cancellation method, its steps are: A, far-end signal segmentation, the far-end signal vector U (n) is divided into 1 far-end sub-band vector U through analysis filter i (n), at the same time, the near-end signal d(n) picked up by the near-end microphone is divided into 1 near-terminal band signals d through the analysis filter i (n); B, signal extraction, the remote terminal with vector U i (n) carry out I extraction through extractor; Obtain far-end input sub-band extraction vector U i (k); also for near terminal with signal d i (n) I extraction is performed by the extractor to obtain the near-terminal strip extraction signal d i (k); C, affine projection, D, filter output, the far-end input subband affine projection matrix X(k) is filtered by a filter to obtain an output vector Y(k); E, echo cancellation, F, The tap weight vector is updated, based on the maximum entropy V(k) update of the current net signal vector to determine the weight vector at the next extraction moment, G, iteration, let k=k+1, repeat A, B, C, D, E, Step F, until the end of the call. It has good echo cancellation effect and strong anti-interference ability.