Methods for preventing or treating neuromuscular or muscular conditions by peripherally administered erythropoietin

a technology of erythropoietin and peripheral administration, which is applied in the direction of growth factors/regulators, animal/human proteins, pharmaceutical non-active ingredients, etc., can solve the problems of cell death, many (but not all) neurons in the central nervous system are easily damaged, and brain function is deeply impaired, so as to improve cognitive function and improve cognitive function
US20070298031A1Inactive Publication Date: 2007-12-27THE KENNETH S WARREN INST
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
THE KENNETH S WARREN INST
Publication Date
2007-12-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods and compositions are provided for protecting or enhancing excitable tissue function in mammals by systemic administration of an erythropoietin receptor activity modulator, such as erythropoietin, which signals via an EPO-activated receptor to modulate the function of excitable tissue. Excitable tissues include central neuronal tissues, such as the brain, peripheral neuronal tissues, retina, and heart tissue. Protection of excitable tissues provides treatment of hypoxia, seizure disorders, neurodegenerative diseases, hypoglycemia, and neurotoxin poisoning. Enhancement of function is useful in learning and memory. The invention is also directed to compositions and methods for facilitating the transport of molecules across endothelial cell tight junction barriers, such as the blood-brain barrier, by association of molecules with an erythropoietin receptor activity modulator, such as an erythropoietin.
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Description

[0001] This application is a Continuation of U.S. application Ser. No. 09 / 717,053, filed Nov. 21, 2000, which is a divisional of U.S. application Ser. No. 09 / 547,220, filed Apr. 11, 2000, now abandoned, which claims benefit under 35 U.S.C. § 119(e) of U.S. provisional patent application No. 60 / 129,131, filed Apr. 13, 1999, the entire contents of each of which is incorporated herein by reference in its entirety.1. FIELD OF THE INVENTION

[0002] The present invention is directed to the use of peripherally administered erythropoietin and other erythropoietin receptor activity modulators or EPO-activated receptor modulators to positively affect excitable tissue function. This includes the protection of excitable tissue, such as neuronal and cardiac tissue, from neurotoxins, hypoxia, and other adverse stimuli, and the enhancement of excitable tissue function, such as for facilitating learning and memory. The present invention is further drawn to methods for transport of substances across ...

Claims

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