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34 results about "Beta lactams" patented technology

Method for simultaneously detecting multi-kind pesticide residues in bee products

InactiveCN101358953ASolve the problem of matrix effectFast wayComponent separationRetention timePhosphate
The present invention relates to a method of simultaneously detecting a plurality of agro-veterinary drug residues in bee products. The extracted liquid trichloroacetic acid or perchloric acid and the extracted liquid acetate, phosphate or borate solution are added into a sample; the pH value is controlled between 4.5 and 9.0; the mixed solution is centrifuged, the filtrate is added into a solid phase extraction column to be extracted, the extraction column is eluted and dried, the column is washed by oxalic acid-methanol solution, the volume of the eluent is defined by the aqueous solution of methanol, the eluent is added into liquid chromatography-tandem mass spectrometry to be analyzed and tested, the acquired chromatographic peak is contrasted with the known standard chromatographic peak of the drug, and according to the retention time and the abundance of the mass spectrum ions, the specific name of the detected drug is determined. The method only requires one pre-treatment of the sample, and thus can simultaneously extract 11 classes and more than 60 kinds of veterinary drug residues, such as sulfonamides, quinolones, macrolides, lincomycins, nitroimidazoles, beta-lactams, tetracyclines, chloromycetins, trinethoprims, chlordimeform, triadimenol and the like, the efficiency of analysis is high, and the detection cost is greatly reduced.
Owner:中华人民共和国江苏出入境检验检疫局

Detection method of residual quantities of various veterinary drugs in culturing or slaughtering environment

The invention provides a detection method of residual quantities of various veterinary drugs in a culturing or a slaughtering environment. With the method, rapid screening and quantitative detection can be carried out upon 61 drugs of 9 categories. The drugs include chlormycetin, beta lactams (penicillins), quinolones, sulfonamides, trimethoprims, macrolides, tetracyclines, and nitroimidazoles. According to the invention, a soil sample or an environmental water sample is added into a phosphate buffering solution; a filtrate obtained through centrifugation is extracted in a solid phase extraction column, and is eluted; the extraction column is dried by blowing, and is washed by using a methanol solution; an obtained eluent is titrated by using a methanol solution; a chromatogram peak of the sample is detected by using liquid chromatography-tandem mass spectrometry; the chromatogram peak is compared with a standard chromatogram peak, such that a specific variety of the detected drug is accurately determined. According to the invention, the sample solution is subject to liquid chromatography-tandem mass spectrometry multi-reaction monitoring selected ion analysis. Through internal standard correction, the recovering rate is 70-120%, and a relative standard deviation RSD is no larger than 18%. Compared with existing technologies, the analysis efficiency is improved by at least 5 times, and the detection cost is 30% of that of existing technologies.
Owner:ANIMAL AND PLANT & FOOD DETECTION CENTER JIANGSU ENTRY EXIT INSPECTION AND QUARANTINE BUREAU

Method and kit for detecting, or determining the quantity of, beta-lactam penicillins

The invention provides a hapten comprising a 6-[D-alpha-aminoacetamido]penicillin derivative crosslinked at the alpha-amino group with a substituted or unsubstituted phenyldicarbaldehyde. In addition, the invention provides an immunogen comprising the aforementioned hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with at least one structural epitope of an intact beta-lactam ring. The invention further provides a method and a kit for detecting, or determining the quantity of, beta-lactam antibiotics, as well as, use of the aforementioned conjugate with the aforementioned antibodies for detecting, or determining the quantity of, beta-lactam antibiotics. The present invention has broad specificity across the main first generation beta-lactams and can be used to test milk and meat and the like for the presence of residual beta-lactam antibiotics.
Owner:NORTHERN BANK LTD

Method for preparing compound beta lactam sodium salt/sodium benemid for injection

InactiveCN1698896ASolve the problem of insolubleAntibacterial agentsOrganic active ingredientsSodium saltBeta lactams
Disclosed is a method for preparing compound beta lactam sodium salt / sodium benemid for injection, which comprises dissolving 1-10 weight parts of probecid into 1-100 parts of water, charging sodium ion-containing alkaline solution, adjusting pH to 6-11 for reaction into salts, filtering and degerming through microporous filtering film, asepsis drying, or filtering with microporous filtering film and charging 10-100 parts of absolute ethyl alcohol or waterless acetone for evolution of solid body, carrying out asepsis dehydration obtain the end product, mixing sodium salt of beta-lactams with the obtained sodium benemid by the proportion of 10:1-1:10 and dissolving into 1-100 parts of water.
Owner:XI AN JIAOTONG UNIV

Immobilized alpha-amino-acid ester hydrolase, preparation and application thereof

The invention discloses a heterogeneous biocatalyst taking alpha-amino-acid ester hydrolase as basis, a preparation method thereof and application in synthesizing amino beta-lactams. The activity of catalyst synthetase is 2,200 U / g by dry weight, and the content of protein is 0.95 g / g by dry weight; and xanthomonas rubrilineans cell biomass is processed in an organic solvent under a pH gradient through low temperature effect to extract enzyme, and enzyme aggregates are deposited and cross-linked to obtain the hydrolase. The alpha-amino-acid ester hydrolase as a catalyst can be synthesized into amino penicillin and amino cephalosporin drugs through acylating a beta-lactam compound by D-phenylglycine methyl ester derivatives in water or in a mixed medium of water and an organic solvent.
Owner:SICHUAN INDAL INST OF ANTIBIOTICS CHINA NAT PHARMA GROUP CORP +1

Pidotimod-containing pharmaceutical composition and preparation method thereof

The invention provides a pidotimod-containing pharmaceutical composition and a preparation method thereof. The pidotimod-containing pharmaceutical composition consists of pidotimod and any antibacterial medicament. The antibacterial medicament may be any of beta-lactams (including as penicillins, cephems and unclassical beta-lactams), aminoglycosides, polymyxins, macrolides, lincomycins, norvancomycins, tetracyclines, chloromycetins, artificial antibacterial medicaments (including sulfonamides, quinolones and furofurans), cholesterols and antiviral medicaments. The unit dosage of the pidotimod is 0.1 to 2 grams, preferably 0.4 to 0.8 gram. The dosage of the antibacterial medicament is determined according to the dosage range of the antibacterial medicament. The composition of the pidotimod and the antibacterial medicament can exogenously and directly kill pathogenic bacteria through the antibacterial medicament and mobilize endogenous anti-infection immunity through an immunomodulator to improve anti-inflection effect, and has excellent synergy.
Owner:STAR LAKE BIOSCI CO INC ZHAOQING GUANGDONG

High-resolution mass spectrometry method for synchronously detecting 152 chemical pollutants in livestock and poultry meat

The invention provides a high-resolution mass spectrometry method for synchronously detecting 152 chemical pollutants in livestock and poultry meat. The method comprises a step of establishing a chemical pollutant standard quality spectrum library, a sample detection step and a screening analysis step. The method covers 152 target compounds such as sulfanilamides, quinolones, quinoxalines, nitroimidazoles, beta-lactams, tetracyclines, macrolides, chloramphenicols, benzimidazoles, nicotinic agonists, beta-receptor agonists, hormones and the like. The method has the advantages that the sample pretreatment method is simple and convenient; the 152 compounds can be screened and confirmed by one-needle sample injection; the detection flux is large; the accuracy is high; and the method is suitable for simultaneous qualitative confirmation detection of various veterinary drug residues in the livestock and poultry meat.
Owner:SHANGHAI ANIMAL EPIDEMIC PREVENTION & CONTROL CENT

Substituted beta-lactams

Disclosed herein is a compound comprising a formulaor a pharmaceutically acceptable salt or a prodrug or a metabolite thereof;Y isA is —(CH2)6—, cis —CH2CH═CH—(CH2)3—, or —CH2C≡C—(CH2)3—, wherein 1 or 2 carbon atoms may be substituted with S or O; or A is —(CH2)m—Ar—(CH2)o— wherein Ar is interarylene or heterointerarylene, the sum of m and o is from 1 to 4, and wherein one CH2 may be substituted with S or O; andD is aryl or heteroaryl.Methods of use are also disclosed.
Owner:ALLERGAN INC

Antibiotic Combinations For Providing Total Solution to the Treatment of Infections

The invention relates to a new pharmaceutical composition, a method of treatment of infection and also a process to prepare the composition. The infectious complications are important causes of morbidity and mortality. Hospital acquired pneumonia (HAP) remains the most severe nosocomial infection in intensive care units. Beta-lactams alone are always considered inadequate when P. aeruginosa and / or methicillin-resistant S. aureus are implicated as pathogens or copathognes. The present invention provides the desired empirical therapy for control of all bacterial infections. The invention provides antibiotic combination products for delivering at least two different antibiotics, through parenteral dosage form comprising protein-synthesis-inhibiting antibiotic which is amikacin or its sulphate salt and non-protein-synthesis-inhibiting antibiotic which is cefepime or its hydrochloride salt. The invention provides a total solution, against multiresistant P. aeruginosa, or Acinetobacter spp. and / or methicillin-resistant S. aureus, and are useful for intramuscular or intravenous administration as antibiotics for hospitalized patients with acute or serious infections. The pharmaceutical compositions described here normally have the least nephrotoxicity and have better efficacy and safety of cefepime plus amikacin combination.
Owner:VENUS REMEDIES LTD

Fluorescent indicator combination, fluorescence array sensor, preparation methods of fluorescent indicator combination and fluorescence array sensor and application

The invention discloses a fluorescent indicator combination, a fluorescence array sensor, preparation methods of the fluorescent indicator combination and the fluorescence array sensor and application. The fluorescent indicator combination comprises a plurality of carbon quantum dot-metal ion complexes formed by full-color fluorescent carbon quantum dots and various metal ions under conditions ofdifferent pH values. The fluorescent array sensor contains a fluorescent indicator; the sensor comprises a plurality of groups of response points; each group of response points comprise three or moreindependent response points respectively corresponding to excitation wavelengths of 360 nm, 450 nm, and 540 nm; and each of the response points comprises at least one carbon quantum dot-metal ion complex. The fluorescent array sensor of the invention can realize qualitative and semi-quantitative detection of four kinds of antibiotics such as tetracyclines, quinolones, beta-lactams and aminoglycosides; and the preparation process of the sensor is simple; the storage time of the sensor is long; the detection sensitivity of the sensor is high; and the sensor can realize simultaneous differentiation and detection of a plurality of antibiotics.
Owner:NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI

Treatment of chlamydiaceae infections by means of beta-lactams

InactiveUS20130053336A1Avoid problemsAvoid tissue damageAntibacterial agentsBiocideDiseaseChlamydiaceae Infections
The invention relates to a method for treating infections of bacteria of the Chlamydiaceae family using a β-lactam. The invention also relates to a method for treating diseases caused by an infection of bacteria of the Chlamydiaceae family using a β-lactam.
Owner:CENT NAT DE LA RECHERCHE SCI +1

Antibacterial drug for targeted therapy of staphylococcal infection by synergizing with antibiotic as well as synthesis method and application of antibacterial drug

InactiveCN108794508AIncrease vitalityExcellent synergistic antibacterial efficacyAntibacterial agentsOrganic active ingredientsAntibacterial agentTarget therapy
The invention designs and synthesizes a novel antibacterial drug ASC for staphylococcus aureus based on a beta-lactam ring of a parent nucleus structure of beta-lactam antibiotic molecules, wherein the ASC is an antibacterial reagent and is also a broad-spectrum inhibitor of beta-lactam antibiotic drug-resistant target protein metal beta-lactamase; the ASC can synergize with three kinds of 7 to 8antibiotics such as beta-lactams, aminoglycosides and tetracyclines to carry out targeted therapy on the staphylococcal infection. The vitality of the antibiotics is increased by 4 to 128 times by combining with 1 [mu]g / ml dosage of ASC.
Owner:NORTHWEST UNIV(CN)

Ophthalmic Pharmaceutical Composition Containing Amphiphilic Polyaspartamide Copolymers

InactiveUS20090221545A1Increase the number ofLess non-productive absorptionBiocideAnimal repellantsPenicillinBeta blocker
The present invention relates in general to the use of amphiphilic graft-type copolymers of polyaspartamide for the ophthalmic administration of drugs, such as for example steroidal and non-steroidal anti-inflammatory agents, antimicrobial agents such as aminoglycosides, macrolides, cephalosporin, tetracycline, quinolones, penicillin, beta-lactams, anti-glaucoma agents such as prostaglandins, alpha- and beta-blockers, inhibitors of carbonic anhydrase, cannabinoids, antiviral agents, diagnostic agents, anti-angiogenic agents, antioxidants.
Owner:S I F I SPA

Pharmaceutical composition for preventing dysbiosis associated with enteral administration of antibiotics

In the first variant, the pharmaceutical composition comprises antibiotic and prebiotic in the form of oligosaccharide of a group comprising fructooligosaccharides, galactooligosaccharides, maltooligosaccharides and isomaltooligosaccharides the polymerisation degree of which ranges from 2 to 10, the particle size is equal to less than 0.3 mm and the purity is of at least 95%, wherein the antibiotic particle size ranges from 20 to 200 mkm and the antibiotic and oligosaccharide are contained with a mass ratio ranging from 1:1 to 1:100 respectively. In the second variant, the pharmaceutical composition comprises antibiotic which is in the form of a powder with the particle size ranging from 20 t0 200 mkm and is selected form a group consisting of beta-lactams, including the combination thereof with bacterial betalactamase inhibitors, azalides, fluoroquinalones, amphenicols, glycopeptides, ansamycins, nitrofurans, phosphonic acid derivatives, cycloserine and trimetoprim. The prebiotic is in the form of a powder oligosaccharide, the polymerisation degree of which ranges from 2 to 10, the particle size is equal to less than 0.3 mm and the purity is of at least 95%, wherein the antibiotic and oligosaccharide are contained with a mass ratio ranging from 1:1 to 1:100 respectively. The above-mentioned compositions are used for preventing intestinal dysbiosis during antibiotic therapy and are perorally administered. The inventive composition produces a stimulating effect on intestinal lactobacilli and bifidobacteria simultaneously inhibiting the growth and proliferation of extraneous or pathogenic microflora.
Owner:DIKOVSKIY ALEKSANDER VLADIMIROVICH +2

Pharmaceutical composition for preventing dysbiosis associated with enteral administration of antibiotics

In the first variant, the pharmaceutical composition comprises antibiotic and prebiotic in the form of oligosaccharide of a group comprising fructooligosaccharides, galactooligosaccharides, maltooligosaccharides and isomaltooligosaccharides the polymerisation degree of which ranges from 2 to 10, the particle size is equal to less than 0.3 mm and the purity is of at least 95%, wherein the antibiotic particle size ranges from 20 to 200 mkm and the antibiotic and oligosaccharide are contained with a mass ratio ranging from 1:1 to 1:100 respectively. In the second variant, the pharmaceutical composition comprises antibiotic which is in the form of a powder with the particle size ranging from 20 t0 200 mkm and is selected form a group consisting of beta-lactams, including the combination thereof with bacterial betalactamase inhibitors, azalides, fluoroquinalones, amphenicols, glycopeptides, ansamycins, nitrofurans, phosphonic acid derivatives, cycloserine and trimetoprim. The prebiotic is in the form of a powder oligosaccharide, the polymerisation degree of which ranges from 2 to 10, the particle size is equal to less than 0.3 mm and the purity is of at least 95%, wherein the antibiotic and oligosaccharide are contained with a mass ratio ranging from 1:1 to 1:100 respectively. The above-mentioned compositions are used for preventing intestinal dysbiosis during antibiotic therapy and are perorally administered. The inventive composition produces a stimulating effect on intestinal lactobacilli and bifidobacteria simultaneously inhibiting the growth and proliferation of extraneous or pathogenic microflora.
Owner:亚历山大·弗拉基米罗维奇·季科夫斯基

Bagasse-based carbon catalyst, as well as preparation method and application thereof

The invention provides a bagasse-based carbon catalyst, as well as a preparation method and application thereof. The catalyst is prepared by using bagasse as a raw material through a process of charring, activating and re-charring. The preparation method comprises the following steps: washing and drying bagasse, heating to a certain temperature in a charring environment, keeping the temperature for a period, naturally cooling, and keeping inert gas to flow in the whole process to obtain charred bagasse; mixing the charred bagasse with a zinc chloride solution, stirring and activating for a period of time at a certain temperature, and drying and storing the activated charred bagasse; heating the activated charred bagasse to a certain charring temperature in a charring environment at a certain heating speed, keeping the temperature for a period of time, stopping heating, naturally cooling, and keeping the inert gas to flow in the whole process to finally obtain a finished product bagasse-based carbon catalyst. The bagasse-based carbon catalyst has an extremely good effect for penicillin broad spectrum beta-lactams in a water body; and the preparation method is simple, raw materials are low in cost.
Owner:WUHAN INSTITUTE OF TECHNOLOGY

Antibiotic combinations for providing total solution to the treatment of infections

The invention relates to a new pharmaceutical composition, a method of treatment of infection and also a process to prepare the composition. The infectious complications are important causes of morbidity and mortality. Hospital acquired pneumonia (HAP) remains the most severe nosocomial infection in intensive care units. Beta-lactams alone are always considered inadequate when P. aeruginosa and / or methicillin-resistant S. aureus are implicated as pathogens or copathognes. The present invention provides the desired empirical therapy for control of all bacterial infections. The invention provides antibiotic combination products for delivering at least two different antibiotics, through parenteral dosage form comprising protein-synthesis-inhibiting antibiotic which is amikacin or its sulphate salt and non-protein-synthesis-inhibiting antibiotic which is cefepime or its hydrochloride salt. The invention provides a total solution, against multiresistant P. aeruginosa, or Acinetobacter spp. and / or methicillin-resistant S. aureus, and are useful for intramuscular or intravenous administration as antibiotics for hospitalized patients with acute or serious infections. The pharmaceutical compositions described here normally have the least nephrotoxicity and have better efficacy and safety of cefepime plus amikacin combination.
Owner:VENUS REMEDIES LTD

Methods for improved in vitro - in vivo efficacy determination

ActiveUS20180087085A9Microbiological testing/measurementPBP inhibitorsMode of action
The invention provides methods for determining and evaluating the in vitro-in vivo activity relationship of the efficacy of families of compounds for infectious diseases such as tuberculosis. The validity of the methods can be confirmed by evaluation of the compounds in animal models, for example, in murine models of tuberculosis. Examples of families of antibacterial compounds that can be evaluated for in vivo efficacy using the in vitro methods described herein include benzimidazoles, pyridopyrazines, pteridines, diphenyl ethers, beta-lactams, PBP inhibitors, and compounds that are non-ribonucleic acid and protein synthesis inhibitors. The methods can be used to evaluate classes of small molecule compounds and inhibitors that may be effective against any bacterial pathogen. The methods aid the identification of compounds, such as various benzimidazoles, with modes of action having activity against clinical isolates, as well as non-replicating persistent bacilli, which can therefore enhance current clinical therapeutic regimens.
Owner:COLORADO STATE UNIVERSITY

A phage capable of lysing multidrug-resistant Pseudomonas aeruginosa and its application in treating infection

The invention discloses cleavable multiple-drug resistant pseudomonas aeruginosa bacteriophage and application thereof in infection treatment. The invention discloses cleavable pseudomonas aeruginosa bacteriophage multiple-resistant to beta-lactams, aminoglycosides and cephalosporin antibiotics, which is named as PaP No.106, preserved in China Center for Type CultureCollection(CCTCC) (Budapest treaty preservation unit, Wuhan University, Wuhan City, China) in June 1, 2012 and has the preservation number of CCTCC NO:M2012200. On the basis of the purpose of novel anti infective therapy, the separated and purified cleavable multiple-drug resistant pseudomonas aeruginosa bacteriophage is proved to be capable of cleaving into multi strains of pseudomonas aeruginosa multiple-resistant to beta-lactams (including carbapenems), aminoglycosides and cephalosporin antibiotics in vitro and vivo, so that the cleavable multiple-drug resistant pseudomonas aeruginosa bacteriophage is proved to be feasible in treatment of pseudomonas aeruginosa infection, and a new therapeutic approach for clinical drug resistant bacteria infection is provided.
Owner:LANZHOU UNIVERSITY

Beta-lactam compound as well as preparation method and application of beta-lactam compound

The invention discloses a beta-lactam compound, and the chemical structural formula of the beta-lactam compound is shown in the specification. The invention also discloses a preparation method and an application of the beta-lactam compound. The beta-lactam compound disclosed by the invention, which has a feature pharmacophores (p-aminobenzenesulfonamide) of sulfonamides drugs and a feature pharmacophore (6-APA or 7-ADCA) of beta-lactams drugs, is obtained by synthesizing on the basis of combination principles. Since the pharmacophores of both drugs are compatible in a molecule, the compound disclosed by the invention has not only the drug properties of sulfonamides drugs and beta-lactams drugs, but also a synergistic effect between two pharmacophores, and thus the antibacterial activity of the compound disclosed by the invention is effectively enhanced and the toxic and side effect of drugs on the human body is reduced. The preliminary studies show that the compound disclosed by the invention exhibits good antibacterial activity against Pseudomonas aeruginosa and is comparable to carbenicillin.
Owner:SOUTHEAST UNIV

Pharmaceutical composition and application thereof

The invention discloses a pharmaceutical composition and an application thereof, which belongs to the technical field of a medicine. The pharmaceutical composition comprises fusaric acid or a fusaricacid compound and one of quinolone, beta-lactams and / or tetracycline antibiotic or a plurality of antibiotics with a mass ratio of 1: 500-128:1, and is used for preparing a medicine for treating and preventing diseases due to drug-resistant bacteria. The composition can effectively solve the drug resistance problem of bacteria on a plurality of antibiotics, the components have synergistic interaction effect, the usage of antibiosis drugs in clinical application of the antibiosis drugs is reduced, side effect and the treatment cost generated due to antibiotic can be correspondingly reduced, andthe sensitivity of the antibiosis drugs can be reduced.
Owner:GUIZHOU MEDICAL UNIV
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