A phage capable of lysing multidrug-resistant Pseudomonas aeruginosa and its application in treating infection

A Pseudomonas aeruginosa, multi-drug resistance technology, applied in the direction of medical raw materials derived from viruses/phages, viruses/phages, antibacterial drugs, etc., can solve problems such as Pseudomonas aeruginosa infection
CN104140957BInactive Publication Date: 2017-04-26LANZHOU UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
LANZHOU UNIVERSITY
Publication Date
2017-04-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses cleavable multiple-drug resistant pseudomonas aeruginosa bacteriophage and application thereof in infection treatment. The invention discloses cleavable pseudomonas aeruginosa bacteriophage multiple-resistant to beta-lactams, aminoglycosides and cephalosporin antibiotics, which is named as PaP No.106, preserved in China Center for Type CultureCollection(CCTCC) (Budapest treaty preservation unit, Wuhan University, Wuhan City, China) in June 1, 2012 and has the preservation number of CCTCC NO:M2012200. On the basis of the purpose of novel anti infective therapy, the separated and purified cleavable multiple-drug resistant pseudomonas aeruginosa bacteriophage is proved to be capable of cleaving into multi strains of pseudomonas aeruginosa multiple-resistant to beta-lactams (including carbapenems), aminoglycosides and cephalosporin antibiotics in vitro and vivo, so that the cleavable multiple-drug resistant pseudomonas aeruginosa bacteriophage is proved to be feasible in treatment of pseudomonas aeruginosa infection, and a new therapeutic approach for clinical drug resistant bacteria infection is provided.
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Description

[0001] Technical field:

[0002] The patent of the invention relates to the bacteriophage capable of cracking clinical multiple-resistant β-lactams (including carbapenems), aminoglycosides and cephalosporin antibiotics Pseudomonas aeruginosa and its application in the treatment of clinical drug-resistant strain infection .

[0003] Background technique:

[0004] Phages were discovered by D. and Twort in 1907 and D. Herelle in 1909. Wherever bacteria exist, corresponding phages may survive. At the beginning of the 20th century, the discovery and clinical application of antibiotics provided an effective way to treat bacterial infections, so that the research on phage biological agents slowed down. But with the increasing threat of multidrug-resistant pathogens, people need to find treatments other than antibiotics to treat infectious problems. Therefore, phage therapy has attracted widespread attention.

[0005] Phage is a general term for viruses that infect microorganisms s...

Claims

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