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3 results about "Beta-lactamase" patented technology
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Beta-lactamases are enzymes (EC 3.5.2.6) produced by bacteria that provide multi-resistance to β-lactam antibiotics such as penicillins, cephalosporins, cephamycins, and carbapenems (ertapenem), although carbapenems are relatively resistant to beta-lactamase. Beta-lactamase provides antibiotic resistance by breaking the antibiotics' structure. These antibiotics all have a common element in their molecular structure: a four-atom ring known as a β-lactam. Through hydrolysis, the enzyme lactamase breaks the β-lactam ring open, deactivating the molecule's antibacterial properties.
Compound for preparing MBL and / or SBL enzyme inhibitor, application and medicine thereof
The invention provides a compound for preparing an MBL and / or SBL enzyme inhibitor, application of the compound and a medicine of the compound, and belongs to the field of medicine. The structure of the compound is shown as a formula I. The compound provided by the invention has good and broad-spectrum inhibitory activity on clinically common metal beta lactamase (MBL) and serine beta lactamase (SBL), can be used as an MBL and / or SBL enzyme inhibitor, and is used for preparing antibacterial drugs, especially drugs for resisting drug-resistant bacteria. In addition, the compound disclosed by the invention is combined with beta-lactam antibiotic meropenem and the like for use, so that the compound has relatively good antibacterial activity on various beta-lactam antibiotic drug-resistant bacteria. The compound disclosed by the invention has great potential in preparation of MBL and SBL dual broad-spectrum inhibitors and medicines for resisting beta-lactam antibiotic-resistant bacteria. The invention provides a new choice for the use of antibacterial drugs, and has a good application prospect.
Owner:SICHUAN UNIV
Heterocyclic compounds which are active as inhibitors of beta lactamases
The invention relates to the use of compounds of formula (1) and the pharmaceutical acceptable salts thereof in the preparation of a medicament used to inhibit the production of beta-lactamases by pathogenic bacteria.
Owner:PFIZER IRELAND PHARMACEUTICALS (CORPORATION)
Thiazole amine-diazabicyclooctanone conjugate derivatives and uses thereof
The application provides a kind of thiazole amine-diazabicyclo octanone conjugate derivative and its use, belong to the field of medicine.The compound provided by the application has good, broad-spectrum inhibitory activity on metal beta lactamase (MBL) and serine beta lactamase (SBL), and can be used for preparing MBL and / or SBL inhibitor.The compound of the application has great potential in preparing MBL and / or SBL inhibitor and antibacterial drug (especially drug for resisting drug-resistant bacteria).
Owner:FUAN PHARM GRP CHONGQING SUNHORIZON PHARM TECH CO LTD