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High concentration pidotimod oral liquid

A liquid preparation, the technology of pidotimod, applied in the field of medicine, can solve the problems of unstable product quality and difficult long-term stable storage, etc., and achieve the effects of high stability, stable storage and improved solubility

Active Publication Date: 2012-07-04
SUZHOU SIXTH PHARMA PLANT OF JIANGSU WUZHONG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is the problem that the pidotimod oral liquid preparation in the prior art does not add any pH regulator, resulting in unstable product quality and difficult long-term stable storage. The reasonable ratio between the parts, so that the quality is stable, and the pidotimod oral liquid preparation is easy to store stably

Method used

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  • High concentration pidotimod oral liquid
  • High concentration pidotimod oral liquid
  • High concentration pidotimod oral liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]

[0032] Dissolve 200 g of glycerin and 304 g of tris in 600 ml of purified water as solution 1; then add 80 g of pidotimod into 200 ml of purified water and stir to form a suspension.

[0033] Under stirring conditions, slowly add solution 1 to the suspension solution, stir well to dissolve pidotimod, then add 50 g of sucralose and 80 g of sorbitol, and stir; use the remaining amount of tris to adjust The pH value of the solution is 4.5-6.5; add 2 g of food essence, add purified water until the total amount of the preparation is 1000 ml, and fill it to obtain a 10 ml, 0.8 g pidotimod oral liquid preparation.

Embodiment 2

[0035]

[0036] Dissolve 2 g of edetate disodium, 200 g of glycerol, and 375 g of tris in 600 ml of purified water as solution 1; then add 80 g of pidotimod into 200 ml of purified water, and stir to form a suspension.

[0037] Under stirring conditions, slowly add solution 1 to the suspension solution, stir well to dissolve pidotimod, then add stevioside 100g and aspartame 30g, stir; adjust the solution with 10% sodium hydroxide aqueous solution 20ml pH value to 4.8-5.6; add 2g of food essence, add purified water until the total amount of the preparation is 1000ml, and fill it to obtain a 10ml, 0.8g pidotimod oral liquid preparation.

Embodiment 3

[0039]

[0040] Dissolve 150 g of calcium sodium edetate and 298 g of tris in 600 ml of purified water as solution 1; then add 50 g of pidotimod into 200 ml of purified water and stir to form a suspension.

[0041]Under stirring conditions, slowly add solution 1 to the suspension solution, stir fully to dissolve pidotimod, then add 40 g of acesulfame potassium and 60 g of xylose, and stir; adjust the pH of the solution with 20 ml of 10% aqueous sodium hydroxide solution value to 4.8-5.6; add food essence 1g, add purified water to a preparation total of 1000ml, and fill to prepare a 10ml, 0.8g pidotimod oral liquid preparation.

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Abstract

The invention provides high concentration pidotimod oral liquid, which can promote human body immune response, effectively reduces times and degree of acute attack of infections caused by bacteria or virus, shortens disease course, can serve as auxiliary medicine antibiotic of acute infection and belongs to the field of medicines. The oral liquid contains constitutions of pidotimod, chemical stabilizer, a potential of hydrogen (pH) adjusting agent, a flavoring agent and the like. Tris-(hydroxymethyl)-aminomethane is used as the pH adjusting agent. The oral liquid is stable in quality and convenient to store for a long time. By means of quantitative proportioning and synergistic effect of all constitutions, when the concentration of the oral liquid is improved, simultaneously the stability and taste of the oral liquid are obviously improved. The oral liquid doesn't contain sugar capable of being absorbed and used by human bodies and is suitable for the old and children.

Description

technical field [0001] The invention relates to an oral liquid preparation containing high-concentration pidotimod, which belongs to the field of medicines. Background technique [0002] The immune response in the human body exists in the occurrence and development of many diseases, including specific immune response and non-specific immune response, which directly affects the health of the human body. Pidotimod is a safe and effective immune function enhancer, which can promote both specific immune response and non-specific immune response. Animal experiments and clinical experiments have shown that although pidotimod has no direct antibacterial and antiviral activity, it can significantly play a role in treating bacteria (pneumococcus, Escherichia coli, Pseudomonas aeruginosa, Proteus, etc.) ), fungus, virus (influenza virus, herpes simplex virus, myocarditis virus and Menge virus, etc.) It can effectively reduce the number and degree of acute attacks and shorten the cou...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K38/05A61K47/18A61K47/04A61P37/04
Inventor 米靖宇姚建林阎政赵唯一汪志超吴振邦王金陵冯志英臧建英
Owner SUZHOU SIXTH PHARMA PLANT OF JIANGSU WUZHONG PHARMA GROUP
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