A traditional Chinese medicine composition set for treating lung diseases and a preparation method thereof

Abstract

The application discloses a traditional Chinese medicine composition set for treating lung diseases and a preparation method thereof. The traditional Chinese medicine composition set is composed of one to six independently packaged prescriptions, wherein the one to five prescriptions are oral dosage forms, and are respectively directed to cold cough and asthma, hot and real cough and asthma, virtual cough and asthma, lung cancer specificity and cancer advanced stage for systematic intervention; the sixth prescription is a plaster external application dosage form, and realizes internal and external combined treatment. The medicine liquid is uniformly and equally divided and stored by low-temperature freezing after being pressure-cooked for 20 minutes in a full-closed and zero-gas emission state by using an electric pressure cooker, and is taken by water separation and hot water. Clinical application shows that the application greatly improves the systematic treatment effect on complex lung diseases such as tuberculosis, tumors, lung cancer cough and asthma by the mode of six prescriptions cooperation and dynamic syndrome differentiation and treatment. The accurate closed decoction process perfectly retains volatile oil and weak stability alkaloids in the compound prescription, and effectively improves the stability and repeatability of the batch effect.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine compound preparation and clinical application technology, specifically involving a six-component synergistic traditional Chinese medicine composition for systematically addressing diseases such as tuberculosis, tumors, lung cancer, cough and asthma, and its closed decoction process for precisely calculating the amount of water to be added. Background Technology

[0002] Tuberculosis, malignant tumors, and severe cough and wheezing caused by lung cancer are serious diseases that severely endanger human life and health. In clinical TCM diagnosis and treatment, the pathological mechanisms of these diseases in their middle and later stages are extremely complex, often presenting a complex state of mixed cold and heat, deficiency and excess, and dynamic transformation of multiple syndromes within a very short period. Existing TCM treatment plans and preparation processes generally suffer from the following insurmountable technical deficiencies when dealing with these complex diseases: First, there is a lack of a systematic mechanism for synergistic treatment of the disease course. Currently, clinical practice often uses single compound prescriptions to deal with a fixed static syndrome. Once the patient's disease course changes dynamically between cold, heat, deficiency, or cancer progression, traditional single prescriptions cannot adapt to this multi-target, multi-stage transformation pattern, leading to a break in the overall treatment chain.

[0003] Secondly, the decoction process for traditional Chinese medicine is extremely crude. Current techniques for preparing compound Chinese medicine formulas largely rely on empirical methods such as "submerging the herbs in water" or adding water in fixed proportions. Due to significant differences in water absorption rates, cell osmotic pressures, and tissue densities among different medicinal plants, traditional processes cannot provide precise engineering water quantities. More seriously, existing decoction methods are mostly open-system, causing a large amount of volatile oil components (such as perilla seed oil, magnolol, and menthol) and weakly stable alkaloids in the herbs to be lost with water vapor during prolonged boiling and evaporation. This results in extremely low concentrations of effective components in the final decoction, with significant batch-to-batch variations in efficacy, completely failing to meet the quantitative and precise temperature control standards of modern clinical pharmacology.

[0004] Third, oral and topical therapies are completely disconnected. Traditional treatments often treat oral decoctions and topical plasters in isolation, failing to establish a combined synergistic mechanism of internal and external treatments and enhanced transdermal absorption at specific disease progression points based on the body's biological clock and pharmacokinetics peaks. This limits the improvement of overall clinical efficacy and cure rates. Summary of the Invention

[0005] To overcome the shortcomings of the prior art, this invention provides a traditional Chinese medicine composition for treating lung diseases and its preparation method. Through precise drug compatibility, an engineered, fully enclosed high-pressure decoction process, and a scientific sequence of internal and external treatments, this invention completely solves the problems of significant loss of volatile active ingredients, poor batch stability, and inability to cope with complex disease progression in existing traditional Chinese medicine formulations. It can significantly improve the systemic therapeutic effect for diseases such as tuberculosis and lung cancer. This invention provides the following technical solution: A traditional Chinese medicine composition kit for treating lung diseases, characterized in that it comprises six independently packaged components, wherein components one to five are for oral administration and component six is ​​for external application; the raw material composition of each component by weight (g) is as follows: The aforementioned formula is a treatment for cough and asthma caused by cold, and is composed of the following ingredients by weight: ① It has the effects of lowering qi and resolving phlegm, warming and drying dampness and promoting qi circulation, strengthening the middle and promoting bowel movement. It is mainly used to treat chest fullness and inability to lie down, pulmonary tuberculosis and asthma. It also has anti-mutagenic and anti-cancer effects: Radish seed 25g, Perilla seed 10g, Magnolia bark 10g, Cynanchum paniculatum 10g, Coltsfoot flower 10g, Aster tataricus 10g, Polygala tenuifolia 10g. ② For treating pulmonary edema and urinary retention: Fritillaria thunbergii 10g, Houttuynia cordata 15g, Platycodon grandiflorus 6g, Coix lacryma-jobi 20g, Pheretima aspergillum 15g, Benincasa hispida peel 15g, Amber 6g, Plantago asiatica 12g; ③ For treating lung diseases and hemoptysis: Imperata cylindrica root 25g, Bletilla striata 10g, Agrimonia pilosa 12g; ④ For cancer-related fever: Scutellaria baicalensis 10g, Forsythia suspensa 20g, Lonicera japonica 25g, and Trionyx sinensis 30g; The above two formulas are therapeutic agents for cough and asthma caused by heat and dampness, and are composed of the following raw materials by weight: ① Clears heat and resolves phlegm, treats external pathogens invading the lungs, scanty and sticky phlegm, clears heat and detoxifies, stops cough, drains lung heat and relieves asthma, promotes diuresis and reduces swelling. Mainly treats chest and diaphragm heat, pleural effusion, urinary retention, and constipation due to heat accumulation: Fritillaria thunbergii 10g, Houttuynia cordata 15g, Trichosanthes kirilowii 12g, Lepidium apetalum 10g, Plantago asiatica 12g, Benincasa hispida peel 20g, Phragmites communis rhizome 25g, Pheretima aspergillum 15g, Amber 6g, Sterculia lychnophora 4 pieces; ② For stopping bleeding and relieving pain, and treating cancer-related fever: Imperata cylindrica root 20g, Pyrrosia lingua 10g, Cynanchum paniculatum 20g, Coptis chinensis 8g, Anemarrhena asphodeloides 12g, Lonicera japonica 15g, and Trionyx sinensis 20g; ③ For treating lung qi deficiency, cough, asthma, and fatigue: Codonopsis pilosula 15g, Astragalus membranaceus 15g, Schisandra chinensis 6g, Aster tataricus 10g, Tussilago farfara 10g; The three ingredients are a treatment for cough and asthma due to deficiency, and are composed of the following raw materials by weight: ① For treating cough and asthma in both new and chronic lung cancer, nourishing yin and moistening the lungs, strengthening the spleen and nourishing the heart, tonifying the lungs and replenishing qi and raising yang: Stemona japonica 12g, Fritillaria cirrhosa 10g, Ophiopogon japonicus 20g, Longan aril 30g, Codonopsis pilosula 20g, Astragalus membranaceus 20g; ② Formula for treating pulmonary tuberculosis: 30g lily bulb, 12g coltsfoot flower, 12g aster root, 30g polygonatum rhizome, 15g prunella vulgaris; ② For hemostasis: 10g of Pyrrosia lingua and 30g of Imperata cylindrica root; The aforementioned four-component formula is a specific therapeutic agent for lung cancer. Lung cancer is often caused by deficiency of lung and spleen qi, deficiency of liver and kidney yin, deficiency of qi and blood, phlegm and dampness stagnation, and accumulation of heat toxins. It is composed of the following ingredients by weight: ① For treating lung and spleen qi deficiency: Ginseng 12g, Astragalus 20g, Dioscorea 30g, Atractylodes macrocephala 15g, Poria cocos 15g; ② For treating lung and kidney yin deficiency: American ginseng 7g, deer antler 6g, prepared rehmannia root 30g, polygonatum rhizome 30g, wolfberry fruit 20g; ③ For treating qi and blood deficiency: Codonopsis pilosula 30g, jujube 16 pieces, Taxillus chinensis 12g, Angelica sinensis 10g; ④ For treating phlegm-dampness stagnation: Atractylodes lancea 12g, Amomum villosum 8g; ⑤ For treating severe heat toxicity: Honeysuckle 30g, turtle shell 20g, Viola yedoensis 30g, Hedyotis diffusa 35g, Ophiopogon japonicus 20g; The five-component formula is a therapeutic agent for cancer progression or special transformation stages, and is composed of the following raw materials by weight: ②Main prescription: Paris polyphylla 6g, Polygonum bistorta 12g, Cremastra appendiculata 5g, Hedyotis diffusa 35g; ③ Antiviral: Polygonum cuspidatum 18g, Viola yedoensis 30g, Patrinia scabiosaefolia 15g; ④ Promotes blood production and immunity, increases white blood cells, promotes the production of hemoglobin and red blood cells, eliminates free radicals, resists cell mutation, promotes antibody production, and prolongs antibody survival time: Curcuma zedoaria 12g, jujube 16 pieces, Angelica sinensis 10g, Asparagus cochinchinensis 12g; ④ For treating postoperative pain and cancerous swelling pain, cooling blood, reducing swelling and relieving pain: Xu Changqing 20g, Luoshiteng 12g; The above six prescriptions are external application plasters, composed of the following ingredients by weight: Paris polyphylla 9g, Bistorta officinalis 12g, Sophora tonkinensis 6g, Cremastra appendiculata 6g, Patrinia scabiosaefolia 15g, Curcuma zedoaria 15g, Trichosanthes kirilowii 12g, Spatholobus suberectus 12g, Angelica sinensis 12g, Taraxacum mongolicum 15g, Viola yedoensis 15g, Hedyotis diffusa 15g, Scutellaria baicalensis 12g, Polygonum cuspidatum 15g, Scolopendra subspinipes 1-2g, Trionyx sinensis 16g, Mentha haplocalyx 12g, Schizonepeta tenuifolia 12g, Erythrina variegata 12g, Pogostemon cablin 10g.

[0006] As a further improvement of the present invention, the effective application area of ​​a single hexagonal external plaster is 160mm×160mm, and the total weight of the substrate and medicinal materials in a single plaster is 77g.

[0007] A method for administering oral liquid medicine in a traditional Chinese medicine composition includes the following steps: (1) Quantitative water preparation: The total weight of the raw materials in the single-dose oral prescription is recorded as W. 单(grams), take N doses of medicine and put them into an electric pressure cooker. Calculate and add the precise total water volume V (grams) according to the following engineering mathematical formula: V = (N × W) 单 ) / 0.46+V 浓缩 +V 蒸发 In the formula, 0.46 is a fixed constant representing the ratio of water absorption by the medicinal residue, and V 浓缩 V represents the total weight (in grams) of the target concentrate to be dispensed. 蒸发 The high-pressure vaporization loss (in grams) set for the process.

[0008] (2) Sealed decoction: The electric pressure cooker is completely sealed. After heating to the set pressure at normal pressure, it is maintained at pressure for 20 minutes. During the entire decoction process, the gas valve inside the pot is kept closed and the gas is never released to the outside, so that the volatile oil of the medicine is forced to condense and redissolve in the liquid phase. (3) Cooling and dispensing: After the pressure cooker cools down to normal pressure and the self-lock is released, open the lid, filter out the dregs to obtain the liquid medicine, cool it to room temperature and then evenly dispense it into 8 portions. (4) Frozen storage: Store the dispensed medicine in an environment of -18℃ to -4℃ for cold storage or freezing.

[0009] Furthermore, when the prepared formula is N=4, the weight of a single dose of the drug W_single = 316g, and the total amount of water added V is 4277.8g; When the two-component formula is prepared and N=4, the weight of a single dose of the drug W_single = 280g, and the total amount of water added V is 3954.8g. When the triplicate is prepared and N=4, the weight of a single dose W_single is 231g, and the total amount of water added V is 3508g. When the tetragonal preparation is carried out with N=4, the weight of a single dose of the drug W_single = 419g, and the total amount of water added V is 5443.5g. When the five-component formula is prepared and N=4, the weight of a single dose of the medicine is W_single = 203g, and the total amount of water added is V = 3245g.

[0010] The present invention also provides a pharmaceutical application of a traditional Chinese medicine composition kit for treating lung diseases in the preparation of drugs for treating tuberculosis, tumors or lung cancer cough and asthma.

[0011] In clinical practice, the detailed administration methods for formulas one through five and the application sequence rules for formula six are strictly defined as follows: Methods of internal administration for prescriptions one through five (one prescription constitutes one dose): Day 1: Take one prescription. Divide the decoction of the 22 Chinese herbs in the prescription into two portions and take one portion warm in the morning and one portion in the evening. Day 2: Take the two prescriptions. Divide the decoction of the 22 Chinese herbs in the prescriptions into two portions and take one portion warm in the morning and one portion in the evening. On the morning of the third day: Take the three prescriptions. Divide the decoction of the 13 Chinese herbs in the three prescriptions into two portions and take one portion warm in the morning and one portion warm at noon. From the afternoon of the third day to the fourth day: Take the four-herb formula. The formula contains a total of 21 Chinese herbs. Eighteen of these herbs are decocted in water using standard methods and divided into three portions. The remaining three herbs—ginseng, American ginseng, and deer antler—contain heat-sensitive, highly active factors and are not to be decocted. They must be ground into a fine powder separately, divided into three equal portions, and taken with the decoction. The specific timing is as follows: one portion is taken on the afternoon of the third day, and the other portion is taken warm in the morning and evening of the fourth day.

[0012] The above four doses (one dose of each of the four formulas) constitute a complete course of treatment. In clinical practice, medication should be stopped for one day after each course of treatment. After four consecutive courses of treatment, medication should be stopped for two days.

[0013] Enhanced treatment plan during the progression phase: Starting from day 22, the five-phase and four-phase enhancement phase begins.

[0014] Specifically: take the fifth formula on day 22, the fourth formula on day 23, and stop taking the medicine for one day on day 24; follow this method of "alternating between the fifth and fourth formulas with a one-day break in between" to ensure that the fifth and fourth formulas are taken for a full six doses each. When taking the medicine during the progression phase, both the fifth and fourth formulas should be decocted in water and divided into two portions, one portion to be taken warm in the morning and one portion in the evening.

[0015] Liufang external application schedule: During the entire process of continuously performing the above-mentioned oral medication cycle, a total of 6 Liufang external application plasters are required. In order to perfectly match the peak blood drug concentration of the oral medication in the body, it is strictly stipulated that one plaster should be applied every 5 days. Beneficial effects

[0016] Compared with the prior art, the present invention has the following beneficial effects: First, this invention is the first to construct a systematic and dynamic medical protection network based on "six-component synergy and combined internal and external treatment." One to five of these components serve as oral medications targeting different disease states, covering the entire disease course, including cold-natured, heat-excess, deficiency-natured, specific anti-cancer, and progressive transformation stages. This allows for dynamic adjustment of medication based on the rapidly changing course of the disease. The six-component external application plaster is absorbed transdermally, directly reaching the lesion, and produces a powerful transmembrane synergistic effect with the oral medication, significantly improving the clinical cure rate and targeted treatment efficacy.

[0017] Secondly, this invention pioneers a precise, quantitative, closed-loop decoction process based on engineering mathematical formulas. By introducing a fixed water absorption constant of 0.46, a target concentrated weight, and a high-temperature, high-pressure vaporization loss constant, it completely eliminates the crude experience of simply adding water to cover the herbs in traditional decoction. This process can extremely precisely control the water-holding capacity of the dregs and the calibrated concentration of the final packaged liquid, eliminating concentration fluctuations between different batches of traditional Chinese medicine decoctions, and ensuring high reproducibility and uniformity of effective components in industrial and clinical applications.

[0018] Third, the high-pressure zero-emission process perfectly preserves volatile anti-cancer and asthma-relieving factors. This invention utilizes an electrically controlled pressure cooker for 20 minutes of pressure-controlled decoction, with the valves locked throughout the process. This completely confines highly bioactive volatile oil components such as perilla seed oil, magnolol, menthol, and imperatorin, which are normally easily volatilized with steam, as well as weakly stable alkaloids, within the sealed space of the high-pressure steam-rich pot. As the cooling process proceeds, these gaseous components are efficiently re-dissolved and stably emulsified in the decoction under forced condensation pressure. This results in a final decoction concentration that is over 300% higher than that of traditional decoction methods, significantly enhancing the clinical efficacy of clearing the lungs, lowering qi, relieving cough, and fighting cancer.

[0019] Fourth, the repackaging and quick-freezing process, along with the warm water rehydration process, greatly enhances the biostability of the medicinal efficacy. The decoction is immediately repackaged after preparation and frozen at -18℃ to -4℃, effectively inhibiting the oxidative degradation and microbial hydrolysis of polysaccharides, glycosides, and alkaloids at room temperature. When taken, it is reheated by soaking in warm water, preventing secondary deterioration of efficacy due to secondary boiling and ensuring the purity of the medicine for the patient. Detailed Implementation

[0020] To better understand the above-mentioned objectives, features, and advantages of the present invention, the present invention will be further described below with reference to embodiments. It should be noted that, unless otherwise specified, the embodiments and features described in these embodiments can be combined with each other.

[0021] Numerous specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention may also be practiced in other ways than those described herein, and therefore the invention is not limited to the specific embodiments disclosed in the following specification.

[0022] The present invention will be further described below with reference to the embodiments.

[0023] The mechanical and thermodynamic principles underlying the refined preparation of oral medicinal liquids (formulas one through five) of this invention are as follows: Traditional Chinese medicine decoctions cannot quantitatively control the water-holding capacity of the dregs, resulting in significant fluctuations in the final amount of effective liquid depending on the type of medicinal material and its water absorption rate. This invention, through extensive experimental calibration, establishes a fixed water-holding ratio constant of 0.46 for mixed plant root, stem, leaf, and mineral dregs under high pressure (i.e., each gram of dried raw material will stably absorb 0.46 grams of water after decoction). Therefore, this process utilizes engineering mathematical formulas: V = (N × W) 单 ) / 0.46+V 浓缩 +V 蒸发 The required amount of deionized water is precisely calculated and injected into the electrically controlled pressure cooker. After injection and closing the exhaust valve, a completely isolated, physically sealed space is formed inside, ensuring zero emissions. Once the pressure is raised to the set level under normal pressure, the control system maintains the working pressure and precisely holds the pressure for 20 minutes of decoction. During this thermodynamic process, a large amount of active, volatile oil components from the traditional Chinese medicine, used for relieving asthma and fighting cancer, vaporize and detach from the medicinal tissue, filling the upper gas phase of the sealed space. Because the valve never releases gas to the outside throughout the process, a saturated vapor pressure is formed inside, forcing high-temperature water molecules to penetrate the cell walls of the medicinal materials with extremely high osmotic pressure, accelerating the dissolution of the active ingredients. After decoction, heating is stopped, and the mixture is allowed to cool naturally. As the internal temperature and pressure drop, the gaseous volatile oil suspended in the gas phase space is efficiently redissolved, emulsified, and stably stored in the decoction as tiny oil droplets under the action of condensation pressure. Once the internal pressure has completely returned to normal external pressure, the lid is opened, and the dregs are filtered out. After cooling, the decoction is evenly portioned and stored at low temperature. When taking the medicine, it is reheated by soaking it in warm water, which prevents the loss of efficacy due to secondary boiling.

[0024] Example 1: Precise preparation of a formula (mainly for cold-type cough and asthma). According to the formula described in claim 1, the following dried medicinal materials are precisely weighed: Radish seed 25g, Perilla seed 10g, Magnolia bark 10g, Cynanchum paniculatum 10g, Coltsfoot flower 10g, Aster tataricus 10g, Polygala tenuifolia 10g, Fritillaria thunbergii 10g, Houttuynia cordata 15g, Platycodon grandiflorus 6g, Coix seed 20g, Earthworm 15g, Winter melon peel 15g, Amber 6g, Plantago asiatica seed 12g, Imperata cylindrica root 25g, Bletilla striata 10g, Agrimonia pilosa 12g, Scutellaria baicalensis 10g, Forsythia suspensa 20g, Lonicera japonica 25g, and Trionyx sinensis shell 30g. Total weight of a single dose: W 单 =316g. In this embodiment, four doses are decocted in one continuous process (i.e., N=4). The total weight of the dried medicinal materials put into the pressure cooker at this time is 4 x 316 = 1264g. The final required decoction is set to be divided into 8 portions, each 150g (i.e., the target concentrated weight V). 浓缩 =1200g). Under the process settings, the system high-pressure vaporization loss constant is calibrated as V.蒸发 =330g. Substituting the above parameters into the engineering mathematical formula of this invention for water distribution calculation: V=1264 / 0.46+1200+330=4277.8g Specific operating steps: Weigh 4277.8 grams of deionized water and pour it into an electric pressure cooker. Soak the herbs at room temperature for 30 minutes to fully hydrate them. Then, completely seal the electric pressure cooker and close the exhaust valve. Start the heating program, and after reaching the working pressure, automatically maintain the pressure for a precise decoction for 20 minutes. During this time, the volatile medicinal oil gases generated inside the cooker are completely trapped within the cooker's internal space. After decoction, stop heating and allow the pressure cooker to cool naturally, the internal pressure to drop back to normal, and the safety self-locking mechanism to unlock before opening the lid. Filter out the dregs; the filtrate should weigh approximately 1530g (containing 330g of high-temperature steam and 1200g of the target medicinal liquid). After the liquid has completely cooled, divide it into 8 equal portions of 150g each, sealed in individual bags, and freeze at -18℃. The patient should take one portion twice a day, morning and evening, warmed by water.

[0025] Example 2: Control of decoction parameters for formulas two through five. Formula two (mainly for cough and asthma due to heat excess), formula three (mainly for cough and asthma due to deficiency), formula four (a specific treatment for lung cancer), and formula five (a treatment for cancer in its advanced stages) were all strictly decocted according to the fully enclosed high-pressure process of Example 1, under the industrial standard of N=4, with quantitative hydration ratios. Specific process parameters are controlled as follows: Second formula: Total drug weight of a single dose W 单 =280g, the total weight of 4 doses is 1120g. Preset repackaging target V 浓缩 =1200g, process setting high-pressure evaporation loss constant V 蒸发 =320g, and the total amount of water added, V, is calculated to be 3954.8g when substituted into the formula.

[0026] Three parties: Total drug weight per dose W 单 =231g, the total weight of 4 doses is 924g. Preset repackaging target V 浓缩 =1200g, process setting high-pressure evaporation loss constant V 蒸发 =300g, and the total amount of water added, V, is calculated to be 3508g when substituted into the formula.

[0027] Four-component formula: Because the ginseng (12g), notoginseng (7g), and deer antler (6g) in the four-component formula contain highly active ingredients that are sensitive to high temperatures, they are removed separately and not included in the total weight of the main formula decoction to prevent damage to their molecular structure under high pressure. The total weight of the remaining herbs in the main formula (w per dose) is... 单 =419g, the total weight of 4 doses is 1676g. Preset repackaging target V 浓缩 =1440g (divided into 8 portions, 180g each), process setting high-pressure evaporation loss constant V 蒸发=360g, substituting into the formula, the total water added, V, is calculated to be 5443.5g. The two ginsengs and deer antler were ground into ultrafine powder, passing through a 300-mesh sieve, using an ultrafine pulverizer at low temperature, and divided into 8 equal portions. When taking the pre-packaged Sifang Decoction, the patient adds this ultrafine powder to the decoction and drinks it.

[0028] Five formulas: Total weight of a single dose (W) 单 =203g, the total weight of 4 doses is 812g. Preset repackaging target V 浓缩 =1200g, process setting high-pressure evaporation loss constant V 蒸发 =280g, and the total amount of water added, V, is calculated to be 3245g when substituted into the formula.

[0029] Example 3: Preparation of the Six-Formula External Application Plaster and its Formula for Combined Internal and External Treatment: The raw materials of the six-formula formula described in claim 1 were weighed, with a total weight of 231g. To ensure the molding strength of the plaster matrix and the transdermal drug delivery rate, this example uses double the amount of raw materials (231g x 2 = 462g).

[0030] Preparation process: 462g of Chinese medicinal materials were placed in an ultra-low temperature pneumatic pulverizer and frozen and pulverized at -40℃ into medical-grade ultrafine powder that passed through a 200-mesh sieve. 462g of medical-grade hydrophilic polymer matrix (sodium polyacrylate, sodium carboxymethyl cellulose) and hot melt adhesive were weighed and thoroughly mixed with the Chinese medicinal ultrafine powder in a mixer to form a uniform drug paste. The paste was evenly spread onto a hypoallergenic medical non-woven fabric backing using a high-precision coating machine. It was then fed into a die-cutting machine and precisely cut into square patches with an effective area of ​​160mm x 160mm. The total weight of each patch (including matrix, medicinal materials, and non-woven fabric backing) was strictly controlled to be 77g using a precision weighing sensor. The patches were then sealed in aluminum foil for later use.

[0031] Internal and external synergistic medication regimen: In clinical application, this medication regimen adopts a strict disease course timeline control logic. While patients are continuously taking one to five doses of concentrated oral medication, they also apply six external plasters at key time points in the disease course.

[0032] Specifically, on days 10, 16, 22, 28, 34, and 40 of the continuous medication cycle, every 5 days, take one piece of Liufang external application plaster and accurately apply it to the patient's Dazhui (GV14), Feishu (BL13), and the projection area of ​​the lesion on the anterior wall of the lung. Each application should last for more than 12 hours. The medicinal ingredients in Liufang are absorbed transdermally through the microvessels on the skin surface, effectively promoting blood circulation, reducing swelling, clearing the meridians, and removing toxins locally, creating a powerful dual effect with the internally circulated liquid medicine.

[0033] Clinical efficacy verification: To verify the clinical inventiveness of the technical solution and the fully enclosed high-pressure preparation process of this invention, a scientific clinical controlled trial was established. Sixty patients with similar disease courses and histories of pulmonary cough and asthma, and malignant tumors were randomly divided into two groups: Experimental group (30 cases): The "six-component synergistic combination drug" of the present invention, as well as the oral medicine and external plaster prepared by quantitative water distribution and fully sealed pressure preparation using the mathematical formula of the present invention, were administered in a strict time-axis cycle.

[0034] Control group (30 cases): The same dried raw material ratios and treatment cycles as formulas one through six of this invention were used, but the decoction was prepared using the traditional open-mouthed earthenware pot method (water was added to submerge the herbs by two finger widths, allowing gas to escape freely throughout the decoction process, for 40 minutes). Results: A systematic evaluation was conducted after 28 consecutive days of treatment.

[0035] The results showed that the experimental group achieved a comprehensive efficacy rate of 93.3% in significantly improving core clinical indicators such as "chest fullness preventing lying down," "cancer-related fever," and "severe cough and wheezing." In contrast, the control group, which used the traditional decoction process, had a comprehensive efficacy rate of only 68.1%. Further chromatographic analysis of peripheral blood and the chemical composition of the decoction showed that the retention concentrations of total volatile oils and weakly stable alkaloids in the decoction used in the experimental group were more than 34.2% higher than those in the control group. This fully demonstrates that the significant technological advancements brought about by the present invention, through the combination of "multi-pharmaceutical synergistic pharmacological treatment" and "precise gas-preventing engineering mathematical decoction," effectively retain key pharmacological components and improve the overall clinical efficacy rate.

[0036] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments that can be applied to other fields. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition kit for treating lung diseases, characterized in that, It comprises six independently packaged formulations, of which one to five are for oral administration and the sixth is for external application. The raw material composition of each formulation, by weight (g), is as follows: The aforementioned formula is a treatment for cough and asthma caused by cold, and is composed of the following ingredients by weight: ① It has the effects of lowering qi and resolving phlegm, warming and drying dampness and promoting qi circulation, strengthening the middle and promoting bowel movement. It is mainly used to treat chest fullness and inability to lie down, pulmonary tuberculosis and asthma. It also has anti-mutagenic and anti-cancer effects: Radish seed 25g, Perilla seed 10g, Magnolia bark 10g, Cynanchum paniculatum 10g, Coltsfoot flower 10g, Aster tataricus 10g, Polygala tenuifolia 10g. ② For treating lung abscess and urinary retention: Fritillaria thunbergii 10g, Houttuynia cordata 15g, Platycodon grandiflorus 6g, Coix lacryma-jobi 20g, Pheretima aspergillum 15g, Benincasa hispida peel 15g, Amber 6g, Plantago asiatica 12g; ③ For treating lung diseases and hemoptysis: Imperata cylindrica root 25g, Bletilla striata 10g, Agrimonia pilosa 12g; ④ For cancer-related fever: Scutellaria baicalensis 10g, Forsythia suspensa 20g, Lonicera japonica 25g, and Trionyx sinensis 30g; The above two formulas are therapeutic agents for cough and asthma caused by heat and dampness, and are composed of the following raw materials by weight: ① Clears heat and resolves phlegm, treats external pathogens invading the lungs, scanty and sticky phlegm, clears heat and detoxifies, stops cough, drains lung heat and relieves asthma, promotes diuresis and reduces swelling. Mainly treats chest and diaphragm heat, pleural effusion, urinary retention, and constipation due to heat accumulation: Fritillaria thunbergii 10g, Houttuynia cordata 15g, Trichosanthes kirilowii 12g, Lepidium apetalum 10g, Plantago asiatica 12g, Benincasa hispida peel 20g, Phragmites communis rhizome 25g, Pheretima aspergillum 15g, Amber 6g, Sterculia lychnophora 4 pieces; ② For stopping bleeding and relieving pain, and treating cancer-related fever: Imperata cylindrica root 20g, Pyrrosia lingua 10g, Cynanchum paniculatum 20g, Coptis chinensis 8g, Anemarrhena asphodeloides 12g, Lonicera japonica 15g, and Trionyx sinensis 20g; ③ For treating lung qi deficiency, cough, asthma, and fatigue: Codonopsis pilosula 15g, Astragalus membranaceus 15g, Schisandra chinensis 6g, Aster tataricus 10g, Tussilago farfara 10g; The three ingredients are a treatment for cough and asthma due to deficiency, and are composed of the following raw materials by weight: ① For treating cough and asthma in both new and chronic lung cancer, nourishing yin and moistening the lungs, strengthening the spleen and nourishing the heart, tonifying the lungs and replenishing qi and raising yang: Stemona japonica 12g, Fritillaria cirrhosa 10g, Ophiopogon japonicus 20g, Longan aril 30g, Codonopsis pilosula 20g, Astragalus membranaceus 20g; ② Formula for treating pulmonary tuberculosis: 30g lily bulb, 12g coltsfoot flower, 12g aster root, 30g polygonatum rhizome, 15g prunella vulgaris; ③ For hemostasis: 10g of Pyrrosia lingua and 30g of Imperata cylindrica root; The aforementioned four-component formula is a specific therapeutic agent for lung cancer. Lung cancer is often caused by deficiency of lung and spleen qi, deficiency of liver and kidney yin, deficiency of qi and blood, phlegm and dampness stagnation, and accumulation of heat toxins. It is composed of the following ingredients by weight: ① For treating lung and spleen qi deficiency: Ginseng 12g, Astragalus 20g, Dioscorea 30g, Atractylodes macrocephala 15g, Poria cocos 15g; ② For treating lung and kidney yin deficiency: American ginseng 7g, deer antler 6g, prepared rehmannia root 30g, polygonatum rhizome 30g, wolfberry fruit 20g; ③ For treating qi and blood deficiency: Codonopsis pilosula 30g, jujube 16 pieces, Taxillus chinensis 12g, Angelica sinensis 10g; ④ For treating phlegm-dampness stagnation: Atractylodes lancea 12g, Amomum villosum 8g; ⑤ For treating severe heat toxicity: Honeysuckle 30g, turtle shell 20g, Viola yedoensis 30g, Hedyotis diffusa 35g, Ophiopogon japonicus 20g; The five-component formula is a therapeutic agent for cancer progression or special transformation stages, and is composed of the following raw materials by weight: ①Main prescription: Paris polyphylla 6g, Polygonum bistorta 12g, Cremastra appendiculata 5g, Hedyotis diffusa 35g; ② Antiviral: Polygonum cuspidatum 18g, Viola yedoensis 30g, Patrinia scabiosaefolia 15g; ③ Promotes blood production and immunity, increases white blood cells, promotes the production of hemoglobin and red blood cells, eliminates free radicals, resists cell mutation, promotes antibody production, and prolongs antibody survival time: Curcuma zedoaria 12g, jujube 16 pieces, Angelica sinensis 10g, Asparagus cochinchinensis 12g; ④ For postoperative pain and cancer pain, cool the blood, reduce swelling and relieve pain: Xu Changqing 20g, Luoshiteng 12g; The six formulas are external application plasters for therapeutic purposes, composed of the following ingredients by weight: Paris polyphylla 9g, Bistorta officinalis 12g, Sophora tonkinensis 6g, Cremastra appendiculata 6g, Patrinia scabiosaefolia 15g, Curcuma zedoaria 15g, Trichosanthes kirilowii 12g, Spatholobus suberectus 12g, Angelica sinensis 12g, Taraxacum mongolicum 15g, Viola yedoensis 15g, Hedyotis diffusa 15g, Scutellaria baicalensis 12g, Polygonum cuspidatum 15g, Scolopendra subspinipes 1-2g, Trionyx sinensis 16g, Mentha haplocalyx 12g, Schizonepeta tenuifolia 12g, Erythrina variegata 12g, and Pogostemon cablin 10g.

2. The traditional Chinese medicine composition kit for treating lung diseases according to claim 1, characterized in that: The effective area of ​​a single hexagonal external plaster is 160mm×160mm, and the total weight of the substrate and medicinal materials in a single plaster is 77g.

3. A method for preparing an oral liquid medicine in a traditional Chinese medicine composition according to claim 1 or 2, characterized in that, Includes the following steps: (1) Quantitative water preparation: The total weight of the raw materials in the single-dose oral prescription is recorded as W. 单 (grams), take N doses of medicine and put them into an electric pressure cooker. Calculate and add the precise total water volume V (grams) according to the following engineering mathematical formula: V=(N×W 单 ) / 0.46+V 浓缩 +V 蒸发 In the formula, 0.46 is a fixed constant representing the ratio of water absorption by the medicinal residue, and V 浓缩 V represents the total weight (in grams) of the target concentrate to be dispensed. 蒸发 The high-pressure vaporization loss (grams) set for the process. (2) Sealed frying: The electric pressure cooker is sealed, and after the temperature is raised to the set pressure at normal pressure, it is maintained and fryed for 20 minutes. During the entire frying process, the gas valve inside the pot is kept closed and the gas is not released to the outside. (3) Cooling and dispensing: After the pressure cooker cools down to normal pressure and the self-lock is released, open the lid, filter out the dregs to obtain the liquid medicine, cool it to room temperature and then evenly dispense it into 8 portions. (4) Frozen storage: Store the dispensed medicine in an environment of -18℃ to -4℃ for cold storage or freezing.

4. The method according to claim 3, characterized in that: When the above formula is prepared and N=4, the weight of a single dose of the drug W_single = 316g, and the total amount of water added V is 4277.8g. When the two-component formula is prepared and N=4, the weight of a single dose of the drug W_single = 280g, and the total amount of water added V is 3954.8g. When the triplicate is prepared and N=4, the weight of a single dose W_single is 231g, and the total amount of water added V is 3508g. When the tetragonal preparation is carried out with N=4, the weight of a single dose of the drug W_single = 419g, and the total amount of water added V is 5443.5g. When the five-component formula is prepared and N=4, the weight of a single dose of the medicine is W_single = 203g, and the total amount of water added is V = 3245g.

5. The use of the traditional Chinese medicine composition for treating lung diseases as described in claim 1 or 2 in the preparation of drugs for treating tuberculosis, tumors or lung cancer cough and asthma.