Heptapeptide prepared from thymopentin and pidotimod, and synthetic method

A synthesis method and product technology, which are applied in the preparation methods of peptides, chemical instruments and methods, peptides, etc., can solve the problems of difficulty in wide-scale popularization and application, high price, etc., to promote non-specific immune responses and promote specific immune responses. Sexual response, the effect of good clinical value

Inactive Publication Date: 2007-12-12
JILIN MINGZHIYUAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although thymosin has a good immune enhancing effect, it is difficu

Method used

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  • Heptapeptide prepared from thymopentin and pidotimod, and synthetic method
  • Heptapeptide prepared from thymopentin and pidotimod, and synthetic method
  • Heptapeptide prepared from thymopentin and pidotimod, and synthetic method

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Embodiment 1

[0035]

[0036] 1 NH 2 -Arg(Mtr)-Lys(Boc)-Asp(OtBu)-Val-Tyr(tBu)-Resin was prepared in the synthesis of Fmoc-Arg(Mtr)-Lys(Boc)-Asp(OtBu)-Val-Tyr(tBu )-Resin, react with 2.0ml pyridine and 2.0ml acetic anhydride at room temperature for 2hr to block the unreacted amino groups on Lys. Methyl chloride was washed three times each (25ml / time), and then the Fmoc protecting group was removed with 40ml of 50% piperidine / DMF solution, reacted with nitrogen gas bubbling at room temperature for 1hr, drained, and washed with methanol, N,N-dimethylformaldehyde Wash the resin three times with amide and dichloromethane (25ml / time), take a small amount of resin in a test tube, add a small amount of ninhydrin / potassium cyanide / phenol mixed solution to qualitatively test whether Fmoc is completely removed, heat in a boiling water bath for 2min, as a solution If the color is dark blue-purple (opaque), it indicates that the removal of Fmoc reaches more than 99%, and the next step reaction can ...

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Abstract

The invention relates to seven-peptide produced with thymus gland five- peptide and pidotimod and the synthesizing method, beloning to chemical medicine production area. The method is to empoly solid synthesing method and connects five- peptide and pidotimod through amido bond. The invention is characterized in that the pidotimod is an artificially- synthesized high- purity dipeptide, which can promote non-specific immune response and specific reaction and is polyphase broad-spectrum immunologic enhancement agent, the new compound is synthesized through connection of carboxyl of pidotimod and amidol of arginine, the metabolic process of thymus gland five- peptide begins from amidol of arginine, so it protects amidol after connection withpidotimod, and changes traditional medicine type of thymus gland five- peptide, so the clinical value is great.

Description

technical field [0001] The invention belongs to the technical field of chemical pharmacy. Background technique [0002] 1. Overview of Thymopentin [0003] The artificially synthesized thymopentin (TP5 for short) is the 32-36th amino acid residue fragment of thymopoietin, but it has all the same physiological functions and pharmacological effects as "thymopoietin". Novel immunomodulators with modulatory effects. It mainly induces T cells and binds to T cell specific receptors to increase the level of intracellular cAMP, thereby inducing a series of intracellular reactions to regulate immune function. It also has a good anti-aging effect, which is mainly through enhancing the activity of superoxide dismutase in serum. This product is used for the treatment of tumors, low immune function and autoimmune diseases. [0004] 1) Pharmacological action of thymopentin [0005] TP5 can normalize the unbalanced immune function of the body and promote the growth and differentiation...

Claims

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Application Information

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IPC IPC(8): C07K7/06C07K1/04
Inventor 王恩思梁涌涛梁铁王明哲柳忠辉延向前
Owner JILIN MINGZHIYUAN BIOTECH
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