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Pidotimod solution capable of being administered from vein

A technology of pidotimod and solution, which is applied in the direction of medical preparations containing active ingredients, dipeptide ingredients, respiratory diseases, etc., and can solve problems such as large differences

Inactive Publication Date: 2006-10-04
CHENGZHENG XINKAI PHARMA FACTORY SUZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the prior art, the present invention has a large difference between the content of the first 6 patent applications and the present invention, while the patent application with the application number CN200510009242.8 protects a compound of pidotimod double salt. studies on stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0034] (1) Pidotimod 4g

[0035] Sodium hydroxide 1g

[0036] Water for injection 100ml

[0037] (2) Pidotimod 6g

[0038] Acetamide amount

[0039] Water for injection 100ml

[0040] (3) Pidotimod 5g

[0041] Appropriate amount of ethylenediamine

[0042] Ethanol 20ml

[0043] Water for injection 100ml

[0044] (4) Pidotimod 12g

[0045] Appropriate amount of diethanolamine

[0046] Propylene glycol 35ml

[0047] Ethanol 100ml

[0048] (5) Pidotimod 15g

[0049] Sodium bicarbonate amount

[0050] Pentyl alcohol 16ml

[0051] Water for injection 100ml

[0052] The pidotimod solution of the present invention is all prepared as follows: take the solubilizer for injection of the prescribed amount, add 80% of the prescribed amount of solvent, dissolve, add the prescribed amount of pidotimod, stir to dissolve and adjust the pH value , and add solvent to the full amount, filter, fill and seal in a container that is allowed to be used for medical injection, pa...

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PUM

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Abstract

The invention provides a Pidotimod solution for intravenous injection, which comprise reactive compound of ((R)-3-[(S)-(5-oxo-2-pyrrolidinyl) carbonyl]-thiazolidine-4-carboxylic acid by a content of 0.4-200mg / ml, solvent for injection and solubilizing agent for injection, the solvent for injection comprises water, non-water solvent or their mixture.

Description

technical field [0001] The invention relates to a pidotimod solution for intravenous injection. Background technique [0002] Pidotimod, namely (R)-3-[(S)-(5-oxo-2-pyrrolidinyl)carbonyl]-thiazolidine-4-carboxylic acid, is a synthetic high-purity Dipeptide is the only immune booster with oral biological activity. In the late 1980s, it was successfully synthesized by the Italian poli chemical company, and it was approved for clinical use in 1993. The drug itself has no antimicrobial activity but is effective in improving the signs and symptoms of infection when combined with antibiotic therapy. [0003] Pidotimod promotes both nonspecific and specific immune responses. It can promote the phagocytic activity of macrophages and neutrophils, improve their chemotaxis, activate natural killer cells; promote the proliferation of lymphocytes caused by mitogens, and make helper T cells (CD4+) and inhibit immune function in low immune function The ratio of...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61K31/427A61K9/08A61P37/04A61P11/00A61P13/02A61P35/00
Inventor 刘志祥阎政米靖宇王金陵臧建英冯志英
Owner CHENGZHENG XINKAI PHARMA FACTORY SUZHOU
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