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Medicinal composition of antiviral medicament and pidotimod, preparation method thereof and medicinal application thereof

An antiviral drug and composition technology, applied in the field of medicine, can solve problems such as viral infection, viral drug resistance, induced drug resistance, etc.

Inactive Publication Date: 2010-01-27
杨喜鸿
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Viral infection is a common problem encountered in clinical medicine. Various antiviral drugs are used clinically to prevent and treat viral infection. Antiviral drugs have become widely used in clinical practice. Drug resistance of the virus will occur, and clinicians often face problems such as refractory viral infection and viral rebound after drug resistance. Therefore, it is necessary to improve the efficacy of antiviral drugs and reduce the use of antiviral drugs. cycle, which has important implications for the use of antiviral drugs and disease treatment
[0003] Studies have found that the immune response exists in the occurrence and development of viral infection. When patients are infected with viruses, they are prone to cause different degrees of immunodeficiency, or when the human immune state is low, they are prone to viral infections. Immunodeficiency It can also aggravate the condition and form a vicious circle. When the patient's own anti-infection immunity is low, relying solely on exogenous antiviral drugs is not enough to achieve efficient antiviral infection, and it is easy to leave hidden dangers of inducing drug resistance

Method used

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  • Medicinal composition of antiviral medicament and pidotimod, preparation method thereof and medicinal application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Embodiment 1. Ganciclovir pidotimod powder for injection (1:2)

[0081] Prescription (1000 sticks): ganciclovir 125g, pidotimod 250g, mannitol 100g, sodium metabisulfite 20g, appropriate amount of sodium hydroxide.

[0082] Preparation method: Mix the above-mentioned materials in the above prescription amount, add 2200ml of water for injection, then add NaOH and stir to dissolve completely, and adjust the pH=7.8-8.8, then add activated carbon for needles and keep warm for half an hour, filter out the activated carbon for needles, Add water for injection to 2500ml, fine filter, and after the content is qualified, divide the filtrate into 1000 vials, freeze-dry according to the preparation process of lyophilized powder injection, seal the package with a stopper, and then prepare 1000 vials for injection Dry powder injection, each medicine contains 0.125g ganciclovir and 0.25g pidotimod. Wherein the mass ratio of ganciclovir and pidotimod is 1:2, and it is used for inject...

Embodiment 2

[0083] Example 2. The compound injection of other drugs against cytomegalovirus and herpes virus infection and pidotimod

[0084] Similar to Example 1, the compound injections of the following 9 antiviral drugs and pidotimod are provided respectively based on the prescription amount of 1 (bottle, bag) injection, for example as follows:

[0085]

[0086] Preparation method: respectively, according to the conventional freeze-dried powder injection or injection preparation process, so that the anti-cytomegalovirus and herpes virus infection drugs and pidotimod are evenly mixed.

Embodiment 3

[0087] Example 3. Oral anti-cytomegalovirus and herpes virus infection medicine and pidotimod compound preparation

[0088] Based on the prescription volume of 1000 units of preparations, the following 4 anti-cytomegalovirus and herpes virus infection drugs and pidotimod oral compound preparations are provided, for example as follows:

[0089]

[0090]

[0091] Preparation method: respectively, according to the prescription amount and the dosage form of the preparation, select appropriate pharmaceutical excipients, and mix the prescription amount of pharmaceutical excipients with anti-cytomegalovirus and herpes virus infection drugs, pidotimod or its intermediate preparations Uniformly, the required oral preparations can be obtained according to the preparation method of conventional preparations.

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Abstract

The invention provides a related medicinal composition of antiviral medicament and pidotimod. The mass ratio of the antiviral medicament to the pidotimod is 1: (0.01-10). The medicinal composition of the invention comprises two combination modes, namely in the first combination mode, the antiviral medicament and the pidotimod are prepared into a compound preparation; and in the second combination mode, the antiviral medicament and the pidotimod are prepared into an individual medicinal preparation respectively, and the two individual medicinal preparations are packed into the same medicinal box. The medicinal composition has the advantages that the medicinal composition can well improve the treatment effect of the antiviral medicament, play a role in synergy and reduce the using amount or the application treatment course of the antiviral medicament by providing the pidotimod or derivative salt thereof as immune promoter medicament at the same time when the antiviral medicament is used for treating viral infection. The invention further provides a preparation method for the medicinal composition and medicinal application thereof.

Description

[0001] Technical field The present invention belongs to the technical field of medicine, and relates to a pharmaceutical composition of antiviral drugs and pidotimod, as well as its preparation method and pharmaceutical application. Background technique [0002] Viral infection is a common problem encountered in clinical medicine. Various antiviral drugs are used clinically to prevent and treat viral infection. Antiviral drugs have become widely used in clinical practice. Drug resistance of the virus will occur, and clinicians often face problems such as refractory viral infection and viral rebound after drug resistance. Therefore, it is necessary to improve the efficacy of antiviral drugs and reduce the use of antiviral drugs. The cycle is of great significance for the use of antiviral drugs and disease treatment. [0003] Studies have found that the immune response exists in the occurrence and development of viral infection. When patients are infected with viruses, they are ...

Claims

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Application Information

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IPC IPC(8): A61K31/427A61K45/00A61P31/12
Inventor 杨喜鸿
Owner 杨喜鸿
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