The present invention relates to a Chinese medicinal compound for enriching qi, nourishing yin, strengthening spleen and tonifying kidney, as well as a preparation method and usages thereof. The raw materials of the effective ingredients for preparing the compound have the following weight portions: 60 to 940 portions of American ginseng, 40 to 620 portions of noble dendrobium, 40 to 620 portions of cherokee rose fruit, 100 to 1,560 portions of eucommia, 100 to 1,560 portions of radix astragali, 60 to 940 portions of angelica, 160 to 2,500 portions of prepared rhizome of rehmannia , 40 to 620 portions of epimedium herb, 40 to 620 portions of multiflower knotweed root, 60 to 940 portions of pachyma cocos, 40 to 620 portions of salvia miltiorrhiza and 30 to 400 portions of liquorice. The Chinese medicinal compound provided by the present invention has the efficacies of enriching qi, nourishing yin, strengthening the spleen and tonifying the kidney, which can be used for effectively preventing and curing fatigue, dizziness and tinnitus, palpitation and night sweat, soreness and weakness on the waist and the knees, nocturia and other symptoms caused by deficiency of the spleen and the kidney in middle and old ages.