The invention discloses a medicine combination of adjusting hypertension, hyperlipidemia and angina, consisting of astragalus, panax, salvia, cynostemma, americanwater plantain, ginkgo biloba, panax notoginseng, hawthorn, mythic fungus, schisandra, fragrant solomonseal rhizome and wolfberry fruit. The medicine combination of the invention has the advantages of invigorating qi and replenishing yin, activating blood and stabilizing pain, nourishing heart and calming mind, replenishing qi and nourishing blood, supplementing spleen and invigorating kidney, promoting moisture and urination, clearing heat, detoxifying and cooling blood, reducing tension, clearing liver, reducing lipid, nourishing yin, improving eyesight, reinforcing kidney, reducing sugar, dual directionally regulating and etc. Meanwhile, the medicine has an obvious effect on treating hypertension, hyperlipidemia, angina, and the hypertensions and anginas caused by unknown reasons.