The invention relates to plaster. The plaster is prepared from, by mass, 15-30 g of safflower carthamus, 15-30 g of rhizoma curcumae, 15-40 g of ligusticum wallichii, 15-40 g of prepared kusnezoff monkshood roots, 15-50 g of processed radix aconiti, 15-50 g of radix notoginseng, 15-50 g of ground beetles, 15-30 g of mastic, 15-50 g of menthol, 15-30 g of bark of eucommia, 15-30 g of radix angelicae pubescentis, 15-30 g of notopterygium roots, 15-40 g of dipsacus asper wall., 15-50 g of roots of largeleaf gentian, 15-40 g of musk, 15-40 g of cornu cervi pantotrichum, 15-40 g of hippocampus japonicus, 15-30 g of centipede and 15-50 g of turtle shells. A specific preparation method of the plaster includes the steps that the materials are mixed and smashed into powder materials, and the powder materials are prepared into the plaster through a conventional method. The plaster can effectively treat bone diseases, cervical spondylosis, lumbar disc herniation, periarthritis of shoulders, sciatica, synovitis, bone hyperplasia, rheumatoid arthritis, ankylosing spondylitis, strain of lumbar muscles, meniscus injury, traumatic injuries, cold in uterus, dysmenorrheal and other diseases, and the use effect is good.