Method for extracting lipide from hippocampus or syngnathus bone meal with supercritical carbon dioxide

A carbon dioxide, supercritical technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, medical raw materials derived from fish feed, etc. The effect of fast speed, strong penetration and high selectivity

Inactive Publication Date: 2013-04-17
NINGBO UNIV
View PDF2 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing hippocampus or sea dragon bone meal lipids are extracted based on traditional solvent extraction methods, most of which use Soxhlet extraction or rapid lipid extraction methods. The above lipid extraction methods all require heating of the solvent, and the operation process is complicated. Moreover, the lipids extracted by the solvent extraction method are not only poor in selectivity, and the lipids are easily oxidized during the heating process, but also cause a certain degree of heavy metal residues or exceed the standard, and the residual solvents will pollute...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for extracting lipide from hippocampus or syngnathus bone meal with supercritical carbon dioxide
  • Method for extracting lipide from hippocampus or syngnathus bone meal with supercritical carbon dioxide
  • Method for extracting lipide from hippocampus or syngnathus bone meal with supercritical carbon dioxide

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0017] A kind of supercritical carbon dioxide of the present invention extracts the method for hippocampus or sea dragon bone meal lipid, specifically comprises the following steps:

[0018] (1) Preparation of hippocampus or sea dragon bone powder: Freeze-dry the raw materials of hippocampus or sea dragon at -40°C for 36-54 hours, and use a medicine pulverizer to crush them. The particle size of bone powder varies greatly, and it can be separated well by passing through a 60-mesh sieve. Raw materials for critical extraction;

[0019] (2) Supercritical extraction: put the hippocampus or sea dragon bone powder sample into a closed extraction kettle for supercritical CO extraction. 2 Fluid extraction, the extraction conditions are extraction temperature of 45-60°C, extraction pressure of 25-40MPa, static extraction for 10min and then adjusting the CO 2 The flow rate is 10-25L / h, and after dynamic extraction for 50-140min, the fatty compounds of hippocampus or sea dragon bone me...

specific Embodiment 2

[0023] The same as Example 1, the difference is that the extraction conditions in step (2) are extraction temperature of 58°C, extraction pressure of 35MPa, static extraction for 10min and adjustment of CO 2 The flow rate is 15L / h, and the dynamic extraction time is 125min. This extraction condition is the best extraction condition, and the extraction rate of hippocampus or sea dragon bone meal lipid reaches a maximum of 1.81%.

specific Embodiment 3

[0024] Same as Example 1, the difference is that the extraction conditions in step (2) are extraction temperature of 45°C, extraction pressure of 25MPa, static extraction for 10min and adjustment of CO 2 The flow rate is 10L / h, and the dynamic extraction time is 50min. The extraction rate was 0.83%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for extracting lipide from hippocampus or syngnathus bone meal with supercritical carbon dioxide. The method is characterized by comprising the following steps: (1) freezing hippocampus japonicus or syngnathus raw material at the temperature of 40 DEG C below zero, crushing the raw material, filtering through a 60-mesh screen, and taking the filterate to obtain the hippocampus or syngnathus bone meal; and (2) loading the hippocampus or syngnathus bone meal into a closed extraction kettle for being extracted by supercritical carbon dioxide fluid at the temperature of 45-60 DEG C and the pressure intensity of 25-40 MPa, adjusting the flow rate of carbon dioxide to 10-25L/h after 10 min of static extraction, then enabling the extract to enter a separation kettle of 60-80 DEG C together with carbon dioxide after 50-140 min of dynamic extraction, and collecting the extract to obtain the product. The method provided by the invention has the advantages that the extraction rate is high, the selectivity is good, no organic solvent remains, extraction and separation are integrated and the lipide is prevented from oxidative deterioration in the extracting process.

Description

technical field [0001] The invention relates to a method for extracting bone meal lipids, in particular to a method for extracting hippocampus or sea dragon bone meal lipids with supercritical carbon dioxide. Background technique [0002] As a medicine, hippocampus has a long history in our country. As early as Liang Dynasty Tao Hongjing’s "Compendium of Materia Medica", it has been recorded that "it is warm in nature and sweet in taste, returns to the liver and kidney meridian, has the functions of warming kidney and strengthening yang, reducing swelling and stagnation, and promoting birth for women. It can treat diseases such as respiratory system disorders, sexual dysfunction, insomnia, fatigue, sore throat, skin diseases and dystocia" when it is called "water horse". In 739 AD, Chen Zangqi used the name of hippocampus for the first time in "Compendium of Materia Medica". It is recorded in "Compendium of Materia Medica" that "it is mainly used for dystocia and blood gas p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K35/56A61K35/60
Inventor 徐永健姜展志宿宇婷李景
Owner NINGBO UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap