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32results about How to "Retain biological properties" patented technology
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Nanotube structures having a surfactant bilayer inner wall coating
InactiveUS20080318245A1Increase surface areaProtect the surfaceBioreactor/fermenter combinationsMaterial nanotechnologyBi layerActive agent
Nanotubes and nanotube array structures comprise (a) a nanotube having an inner wall portion; and (b) a bilayer coating formed on the inner wall portions, with the bilayer coating comprised of surfactants. A secondary compound such as a protein, peptide or nucleic acid may be associated with the bilayer coating. The structures are useful for, among other things, affinity purification, catalysis, and as biochips.
Owner:NORTH CAROLINA STATE UNIV
Compositions of Natural Extracts and Use Thereof in Methods for Preventing or Treating Diseases
PendingUS20190224193A1Additive and synergistic effectImprove permeabilityMetabolism disorderTripeptide ingredientsDiseaseCannabis
A composition for reducing miR-3120 expression in a cell or tissue of a subject comprises at least one oil or extract selected from a group comprising an orange, frankincense and cannabis oil or extract. A method for reducing miR-3120 expression in a cell or tissue of a subject comprises administering to the subject a composition comprising at least one oil or extract selected from the group comprising an orange, frankincense and cannabis oil or extract.
Owner:REID CHRISTOPHER BRIAN
Method for undisturbed relocation and recovery of soil and die for fixing undisturbed earthwork
InactiveCN101554105AMaintain status quoReduce disturbanceSoil-working equipmentsRigid containersBiological propertyButt joint
The invention relates to a method for undisturbed relocation and recovery of soil and a die for fixing undisturbed earthwork. The method comprises the following steps of: cutting the soil as a plurality of regular earthworks, fixing the earthworks by a fixed die on, hoisting and stably transporting the fixed die to the relocation destination, carrying out seamless assembly in a containing pit by a corresponding sequence, pouring the butt-jointed soil edges by the slurry and prompting the butt-jointed soil edges to be melted quickly. The die for fixing the undisturbed earthwork comprises an enclosure body, a cutting soleplate movably butt-jointed to the bottom end of the enclosure body and a fastening component leading the enclosure body to be fixedly connected with the soleplate; the upper end of the enclosure body is provided with a hoisting hook along the internal side. The method can effectively maintain the original state of the soil, has small disturbance to the soil structure, reserves the physical property and biological property of the relocated soil to maximum extent and continues the soil information. The relocation is not limited by time, the relocation can be carried out at any growth stage of crops, the whole progress of the test is not affected, the relocation efficiency is high and the cost is low.
Owner:HENAN ACAD OF AGRI SCI
Acellular bone matrix composite with partially anti-freezing function and cell capturing function and preparation method thereof
InactiveCN101884808AAvoid formingIncrease distancePharmaceutical containersMedical packagingFiberCells bone
The invention relates to an acellular bone matrix composite with a partially anti-freezing function and a cell capturing function and a preparation method thereof, and the bone matrix material is formed by assembling sulfuric acid polysaccharide with an anti-freezing function and chitosan or fibronectin onto the surfaces of an acelluar bone matrix. The preparation method of the acellular bone matrix composite comprises the following steps: firstly, preparing the acellular bone matrix material; and then assembling the sulfuric acid polysaccharide and other materials with the anti-freezing function and the chitosan or the fibronectin onto the surfaces ( the inner surface and the outer surface) of the acelluar bone matrix in a layer upon layer mode under an intermolecular electrostatic interaction or ligand interaction method so as to form a controlled-release coating. The composite retains the natural structure, biological characteristics and low immunogenicity of bone tissues, and simultaneously the composite coating has favorable anti-freezing function and seeded cell capturing function. The composite serving as a material for filling bone defects or a tissue engineering bone bracket has obvious function of promoting vascularization, and has scientific, reasonable, simple, convenient and feasible processing and manufacturing.
Owner:INST OF FIELD OPERATION SURGERY NO 3 MILITARY MEDICL UNIV PLA
Strontium and iron doped hydroxyapatite collagen fiber composite scaffold material and preparation method thereof
ActiveCN105536072AHigh modulus of elasticityRetain biological propertiesIron compoundsProsthesisPhysical chemistryPharmaceutical drug
The invention discloses a strontium and iron doped hydroxyapatite collagen fiber composite scaffold material and a preparation method thereof. The scaffold material is prepared through compounding collagen fibers having a three dimensional connective porous structure with strontium and iron doped hydroxyapatite with a good drug therapy function. The preparation method mainly comprises the following steps: preparing strontium and iron doped hydroxyapatite through a co-precipitation technology; and compounding the collagen fibers through a dipping-pulling technology. The functional bone restoration scaffold material has excellent biologic performances, very good mechanical strength and toughness and a three dimensional connective macro-porous structure, can deliver drugs to a specific position under the induction of a magnetic field, can restore and treat bone defects induced by various bone diseases, and has wide application prospect in the field of bone restoration materials and biological drugs.
Owner:SHANGHAI NAT ENG RES CENT FORNANOTECH
Tissue cultivating method of choerospondias axillaries
InactiveCN104996300ARetain biological propertiesReproduce fastHorticulture methodsPlant tissue cultureAxillary budBiological property
Owner:孟祥松
Hepatoma cell line STL-C1 derived from human hepatoma a-carcinoma tissue and establishment method thereof
ActiveCN105861441AGood tumorigenicityStable passageCell dissociation methodsCulture processLesionIndividual animal
The present invention relates to the field of microbial animal cells, and specifically a hepatoma cell line STL-C1 derived from human hepatoma para-carcinoma tissue. The cell line has a preservation number CCTCC No:C201630. The present invention also provides an establishment method and application of the cell line. The established hepatoma cell line STL-C1 is derived from human hepatocellular hepatoma para-carcinoma tissue, and can be cultured in vitro for a long term and has stable passage; and in vivo experiments show that the cell line still has good tumorigenic property, and is completely different from the currently existing established common hepatoma cell lines and even from the hepatoma cancer embolus cell line. The hepatoma cell line STL-C1 has important usage and reference value to the study of the formation of satellite lesions, and biological behaviors suahc as recurrence and transfer of primary hepatic carcinoma, is a novel cell model for basic and clinical research of hepatoma, and has broad application prospects.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Nanotube structures having a surfactant bilayer inner wall coating
InactiveUS7521225B2Increase surface areaProtect the surfaceBioreactor/fermenter combinationsMaterial nanotechnologyCrystallographySURFACTANT BLEND
Nanotubes and nanotube array structures comprise (a) a nanotube having an inner wall portion; and (b) a bilayer coating formed on the inner wall portions, with the bilayer coating comprised of surfactants. A secondary compound such as a protein, peptide or nucleic acid may be associated with the bilayer coating. The structures are useful for, among other things, affinity purification, catalysis, and as biochips.
Owner:NORTH CAROLINA STATE UNIV
Transmembrane Dps (starvation-induced DNA binding protein) and application
ActiveCN110283251AEasy to purifyHigh yieldPeptide/protein ingredientsAntinoxious agentsAntioxidant proteinBiocompatibility Testing
The invention belongs to the field of bioscience, and particularly relates to transmembrane Dps (starvation-induced DNA binding protein) and an application. By means of rational design of a protein nanocage derived from prokaryotes, the protein nanocage is enabled to be an antioxidant protein nanomaterial which can be applied to mammalian cells. The protein nanomaterial is characterized in that transportation across mammalian cell membranes of Dps is realized by fused expression of His-tag and Avitag (LNDIFEAQKIEWHE) at the N-terminal of Dps; the cells can be protected from being damaged by ROS (Reactive Oxygen Species); meanwhile, the protein nanomaterial is good in biocompatibility, simple to design, easy to prepare, high in yield and suitable for large-scale production.
Owner:WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI
Fully human anti-staphylococcus aureus alpha-hemolysin recombinant antibody
ActiveCN110437334AStrong penetrating powerSmall molecular weightHybrid immunoglobulinsImmunoglobulins against bacteriaSingle-Chain AntibodiesStaphylococcus cohnii
The invention discloses an anti-staphylococcus aureus alpha-hemolysin single-chain antibody scFv2 or scFv46, further discloses an anti-staphylococcus aureus alpha-hemolysin recombinant antibody scFv2-Fc or scFv46-Fc containing the scFv2 or scFv46 and a human antibody constant region Fc segment amino acid sequence, and further discloses a universal expression vector sp-Fc / pcDNA3.1 of the fully human anti-staphylococcus aureus alpha-hemolysin recombinant antibody. The nucleic acid sequence of an encoding gene of the universal expression vector is shown in SEQ ID No:13. The invention further discloses a eukaryotic expression vector of the fully human anti-staphylococcus aureus alpha-hemolysin recombinant antibody. The eukaryotic expression vector is obtained by inserting the single-chain antibody into the sp-Fc / pcDNA3.1. The invention further discloses a recombinant expression vector sp-scFv2-Fc / pMH3 or sp-scFv46-Fc / pMH3.
Owner:SOUTHWEST MEDICAL UNIVERISTY
Metal nanocluster scaffolds
ActiveUS20210002330A1High fluorescence intensityImprove stabilityPolypeptide with localisation/targeting motifHydrolasesChemical reactionPhotosensitizer
The present invention refers to a protein-stabilized metal nanocluster comprising a variant of the helix A of the CTPR. It is also related to its uses for delivering of a drug, for interfering a metabolic reaction, for catalyzing a chemical reaction, as biocatalyst, for detecting an analyte, for phasing crystallographic data set, for cell labeling, for specific protein labeling, as biosensor, as a temperature sensor, as photosensitizer, or for the manufacture of an optoelectronic device.
Owner:ASOCIACION CENT DE INVESTIGACION COOP & BIOMATERIALES - CIC BIOMAGUNE
Convenient preparation method for high-performance collagen gel
The invention discloses a convenient preparation method for a high-performance collagen gel. The method is characterized by comprising the following steps: placing a self-assembled collagen gel into an alcohol solution and performing gradient dewatering, thereby replacing the solvent in the collagen gel with the alcohol solution, and then contracting the size of the collagen gel at a certain degree, thereby acquiring the high-performance collagen gel. The whole technological operation is simple and the time consumption is less and is about 18-34h; the collagen cannot denature under the effect of the technical temperature; the elasticity modulus of the prepared high-performance collagen gel can reach up to 11-53 times of that of the untreated collagen gel and can be widely applied to the fields of tissue repair, drug sustained release and clinical medicine.
Owner:SICHUAN UNIV
Preparation method of organic silicon modified collagen membrane
The invention discloses a preparation method of an organic silicon modified collagen membrane. The method comprises the steps: firstly, completely dissolving animal collagen by using an acetic acid solutionto be prepared into a collagen solution; after removing bubbles, carrying out flow casting to form a membrane, and drying the membrane to obtain a white transparent collagen membrane; and then, placing the prepared collagen membrane into an inorganic alkaline solution, adding organic silicon, and carrying out a reaction at normal temperature, and after ending the reaction, washing the surface, and drying the collagen membrane to obtain a modified collagen membrane. The method is simple, convenient, very short in time consumption, low in equipment requirement and capable of shortening the preparation period and reducing the production cost; in addition, the hydrophobicity of the collagen membrane is greatly improved, an obstacle that the collagen membrane is applied to the commerce is basically eliminated, and the phenomenon that an exogenous toxic chemical substance enters the collagen membrane to affect the edibility of the collagen membrane is avoided.
Owner:SICHUAN UNIV
Undenatured collagen based biosurfactant with ionic liquid as reaction medium and preparation method thereof
ActiveCN106076193ARetain biological propertiesImprove surface activityTransportation and packagingMixingOrganic solventFreeze-drying
The invention discloses an undenatured collagen based biosurfactant with ionic liquid as the reaction medium and a preparation method thereof. The method is characterized by: dissolving 1 part by weight of freeze dried undenatured natural collagen in 50-300 parts by weight of ionic liquid, adding 0.003-0.3 part by weight of a long-chain hydrophobic carbonyl compound dissolved by 5-15 parts by weight of an organic solvent, carrying out reaction under 4-10DEG C ice bath for 6-10h, at the end of the reaction using acid to adjust pH to 9-10, then slowly adding 0.1-0.5 part by weight of short-chain dicarboxylic anhydride dissolved by 5-15 parts by weight of an organic solvent, at the same time using alkali to stabilize pH at 9-10, carrying out reaction under 4-10DEG C ice bath for 3-5h, at the end of reaction using acid to adjust pH till precipitate appears, then using deionized water with pH adjusted by acid to 4.2-4.6 to wash the precipitate 3-5 times, thus obtaining the neutral and water soluble undenatured collagen based biosurfactant with high hydrophobic long-chain grafting ratio and good surface activity.
Owner:SICHUAN UNIV
A kind of strontium, iron doped hydroxyapatite collagen fiber composite scaffold material and preparation method
ActiveCN105536072BHigh modulus of elasticityRetain biological propertiesIron compoundsProsthesisFiberApatite
The invention discloses a strontium and iron doped hydroxyapatite collagen fiber composite scaffold material and a preparation method thereof. The scaffold material is prepared through compounding collagen fibers having a three dimensional connective porous structure with strontium and iron doped hydroxyapatite with a good drug therapy function. The preparation method mainly comprises the following steps: preparing strontium and iron doped hydroxyapatite through a co-precipitation technology; and compounding the collagen fibers through a dipping-pulling technology. The functional bone restoration scaffold material has excellent biologic performances, very good mechanical strength and toughness and a three dimensional connective macro-porous structure, can deliver drugs to a specific position under the induction of a magnetic field, can restore and treat bone defects induced by various bone diseases, and has wide application prospect in the field of bone restoration materials and biological drugs.
Owner:SHANGHAI NAT ENG RES CENT FORNANOTECH
Anti-helicobacter pylori recombinant antibody, preparation method and application
ActiveCN113480645APenetratingSmall molecular weightAntibacterial agentsFungiAntiendomysial antibodiesHelicobacter
The invention discloses an anti-helicobacter pylori recombinant antibody, a preparation method and application, belongs to the technical field of biological medicine, and particularly relates to the technical field of antibody engineering.The antibody is rFab and comprises VH and VL, the VH and the VL are formed by fusing one end of a fully human CH1-CL fragment, the amino acid sequence of the VH is shown as SEQ ID NO: 1, the amino acid sequence of the VL is shown as SEQ ID NO: 2, the amino acid sequence of the CH1-CL is shown as SEQ ID NO: 3, the rFab is formed by connecting a light chain and a heavy chain in the Fab antibody through a full human CH1-CL fragment by virtue of a gene recombination technology, and meanwhile, the defects of tedious preparation process and low stability of the Fab antibody are overcome.
Owner:甘肃中科博瑞生物工程有限公司
Marked Pestivirus suis C strain expressing enhanced green fluorescent protein and construction method and application thereof
InactiveCN105861453ARetain biological propertiesPreserve immunogenicitySsRNA viruses positive-senseVirus peptidesMicroorganismBiological property
The present invention discloses a marked Pestivirus suis C strain expressing enhanced green fluorescent protein and construction method and application thereof, and belongs to construction and application of marked Pestivirus suis C strain. A C strain infectious clone is used as a skeleton, the Pestivirus suis Shimen strain Npro protein is used to substitute a C strain Npro protein, then an EGFP gene is introduced between No. 13 and 14 amino acids of the Npro protein to obtain an marked Pestivirus suis C strain expressing enhanced green fluorescent protein, wherein the strain has microbial preservation number: CGMCC No. 12039. The marked Pestivirus suis C strain can stably express EGFP gene, is successfully observed with green fluorescence, retains biological properties and immunogenicity of the parental viruses, and can be applied to the preparation of marked vaccines for prevention of Pestivirus suis. The present invention confirms that the C strain Npro protein can be modified to obtain marked Pestivirus suis, so as to lay foundation for the development of marked C strain vaccine.
Owner:HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Adult nephroblastoma HANB cell strain and culturing method and application thereof
InactiveCN102559597APromote growthEasy to trainTumor/cancer cellsAnimal husbandryAdult NephroblastomaCell culture
The invention discloses an adult nephroblastoma HANB cell strain with the collection number of CCTCC NO:C201133. A culturing method comprises the following steps of: culturing in-vitro ascites of a patient suffering from poorly-differentiated anaplastic nephroblastoma; passing; freezing for preserving; and recovering; the cell growing speed is high, the quantity is large, the quality is uniform, and a cell culturing method is simple; as proved by evaluation on the biological characteristics such as cell form, protein structure, chromosome, neoplastic rate and the like of the cell strain, the cell strain keeps the biological characteristics of a primary tumor; and due to the usage of the adult nephroblastoma HANB cell strain to the establishment of a nephroblastoma model, a research model is provided for the occurrence, transfer mechanism and clinical treatment of the nephroblastoma.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY
Platelet-rich plasma (PRP)-loaded pancreatic decellularized scaffold and preparation method thereof
InactiveCN110694114AImprove adhesionPromote proliferationTissue regenerationProsthesisVascularizesDecellularized scaffold
The invention discloses a platelet-rich plasma(PRP)-loaded pancreatic decellularized scaffold and a preparation method thereof and belongs to the technical field of pancreatic tissue engineering. PRPrich in various vascularization promoting growth factors is assembled in vessels of the pancreatic decellularized scaffold while human umbilical vein endothelial cell is planted in the vessels of thepancreatic decellularized scaffold, the loaded PRP is activated slowly by collagenous fiber of the pancreatic decellularized scaffold to releases a great quantity of growth factors slowly continuouslylocally, thereby providing an ideal environment for adhesion and proliferation of the human umbilical vein endothelial cell surrounding the inherent vascular networks in the scaffold; the PRP loadedpancreatic decellularized scaffold keeps the natural structure, biological characteristics and low immunogenicity of the pancreatic tissue; the growth factors which are slowly released continuously locally after the scaffold is transplanted in vivo have a remarkable vascularization promoting function; the scaffold is convenient to operate and has good controllability; generation of new vessels inthe scaffold is facilitated.
Owner:AFFILIATED HOSPITAL OF NANTONG UNIV
Adult nephroblastoma HANB cell strain and culturing method and application thereof
InactiveCN102559597BPromote growthEasy to trainTumor/cancer cellsProtein structureTransfer mechanism
The invention discloses an adult nephroblastoma HANB cell strain with the collection number of CCTCC NO:C201133. A culturing method comprises the following steps of: culturing in-vitro ascites of a patient suffering from poorly-differentiated anaplastic nephroblastoma; passing; freezing for preserving; and recovering; the cell growing speed is high, the quantity is large, the quality is uniform, and a cell culturing method is simple; as proved by evaluation on the biological characteristics such as cell form, protein structure, chromosome, neoplastic rate and the like of the cell strain, the cell strain keeps the biological characteristics of a primary tumor; and due to the usage of the adult nephroblastoma HANB cell strain to the establishment of a nephroblastoma model, a research model is provided for the occurrence, transfer mechanism and clinical treatment of the nephroblastoma.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY
Undenatured collagen-based biosurfactant using ionic liquid as reaction medium and preparation method thereof
ActiveCN106076193BRetain biological propertiesImprove surface activityTransportation and packagingMixingOrganic solventHydrazine compound
The invention discloses an undenatured collagen-based biosurfactant using an ionic liquid as a reaction medium and a preparation method thereof. Add 0.03-0.3 parts by weight of long-chain hydrophobic carbonyl compound dissolved in 5-15 parts by weight of organic solvent, react in an ice bath at 4-10°C for 6-10 hours, adjust the pH to 9-10 with acid after the reaction, and then slowly add 0.1 to 0.5 parts by weight of short-chain dibasic acid anhydride dissolved in 5 to 15 parts by weight of organic solvent, while stabilizing the pH at 9 to 10 with alkali, and reacting in an ice bath at 4 to 10°C for 3 to 5 hours. After the reaction, use acid Adjust the pH until precipitation occurs, and the precipitate is washed with deionized water 3 to 5 times with an acid to adjust pH = 4.2 to 4.6 to obtain undenatured collagen-based biosurfactant with high hydrophobic long chain grafting rate, good surface activity and neutral water solubility agent.
Owner:SICHUAN UNIV
Construction method and application of PDX model based on osteogenic niche microenvironment modification
ActiveCN113424799AImprove the success rate of transplantationRetain biological propertiesCompounds screening/testingAnimal husbandryDiseaseOsteocyte
The invention belongs to the technical field, and particularly relates to a construction method and application of a PDX model based on osteogenesis niche microenvironment modification. The construction method comprises the following steps: placing human umbilical cord mesenchymal cells on a biological derived bone, inducing and differentiating the human umbilical cord mesenchymal cells into osteoblasts to obtain the osteoblast-loaded biological derived bone, planting the osteoblast-loaded biological derived bone under the skin of a mouse, and inoculating the planting part of the biological derived bone under the skin of the mouse with primary leukemia cells or tumor cells. A novel microenvironment modified PDX model is constructed, and a disease research model which is high in transplantation success rate, stable in passage and capable of effectively retaining the biological characteristics of primary cells is provided for research of leukemia or tumor cell drug resistance formation mechanism and drug screening.
Owner:中国人民解放军陆军特色医学中心
A kind of convenient preparation method of high-performance collagen gel
The invention discloses a convenient preparation method for a high-performance collagen gel. The method is characterized by comprising the following steps: placing a self-assembled collagen gel into an alcohol solution and performing gradient dewatering, thereby replacing the solvent in the collagen gel with the alcohol solution, and then contracting the size of the collagen gel at a certain degree, thereby acquiring the high-performance collagen gel. The whole technological operation is simple and the time consumption is less and is about 18-34h; the collagen cannot denature under the effect of the technical temperature; the elasticity modulus of the prepared high-performance collagen gel can reach up to 11-53 times of that of the untreated collagen gel and can be widely applied to the fields of tissue repair, drug sustained release and clinical medicine.
Owner:SICHUAN UNIV
Fully human anti-Staphylococcus aureus α-hemolysin recombinant antibody
ActiveCN110437334BStrong penetrating powerSmall molecular weightHybrid immunoglobulinsImmunoglobulins against bacteriaSingle-Chain AntibodiesAntiendomysial antibodies
Owner:SOUTHWEST MEDICAL UNIVERISTY
Avian influenza and MD bivalent vaccine rMDV-HA virus strain and construction method
InactiveCN101575616BRetain biological propertiesReduce manufacturing costGenetic material ingredientsFermentationDiseaseReverse transcriptase
Owner:YANGZHOU UNIV
Radioactive iodine-17- allylamino-17-demethoxygeldanamycin and its preparation method
InactiveCN1995020BIncrease polarityImprove targetingRadioactive preparation carriersIsotope introduction to organic compoundsGeldanamycinMedicine
Owner:SOUTHEAST UNIV
A kind of tissue culture method of southern jujube
InactiveCN104996300BRetain biological propertiesReproduce fastPlant tissue cultureHorticulture methodsAxillary budBud
The invention discloses a tissue cultivating method of choerospondias axillaries. The method includes the steps of taking axillary buds of choerospondias axillaries, disinfecting outer surfaces, cultivating the axillary buds in an MS medium, screening and disinfecting the axillary buds, putting the disinfected axillary buds in an inducing medium to be cultivated at a temperature of 10 DEG C to 12 DEG C under the luminance of 1800 LX 8 hours per day for 6 weeks, shifting the axillary buds into a subculture medium to be cultivated to continue multiplication and cultivation for 4 weeks, and shifting the buds into a root medium to be cultivated to conduct rooting cultivation for 4 weeks. By means of the method, the genders of choerospondias axillaries seedlings can be controlled and cultivated in an oriented mode by recording the genders of collected female parents, the method is free of season limits, keeps the biological characteristics of original plants to the maximum extent, and can well prevent the browning in the cultivation process, the reproduction speed is high, and the rooting rate is 98% or higher.
Owner:孟祥松
Acellular Bone Matrix Composite Material with Local Anticoagulation and Cell Capture and Preparation Method
InactiveCN101884808BAvoid formingIncrease distancePharmaceutical containersMedical packagingFiberCells bone
The invention relates to an acellular bone matrix composite with a partially anti-freezing function and a cell capturing function and a preparation method thereof, and the bone matrix material is formed by assembling sulfuric acid polysaccharide with an anti-freezing function and chitosan or fibronectin onto the surfaces of an acelluar bone matrix. The preparation method of the acellular bone matrix composite comprises the following steps: firstly, preparing the acellular bone matrix material; and then assembling the sulfuric acid polysaccharide and other materials with the anti-freezing function and the chitosan or the fibronectin onto the surfaces ( the inner surface and the outer surface) of the acelluar bone matrix in a layer upon layer mode under an intermolecular electrostatic interaction or ligand interaction method so as to form a controlled-release coating. The composite retains the natural structure, biological characteristics and low immunogenicity of bone tissues, and simultaneously the composite coating has favorable anti-freezing function and seeded cell capturing function. The composite serving as a material for filling bone defects or a tissue engineering bone bracket has obvious function of promoting vascularization, and has scientific, reasonable, simple, convenient and feasible processing and manufacturing.
Owner:INST OF FIELD OPERATION SURGERY NO 3 MILITARY MEDICL UNIV PLA
Metal nanocluster scaffolds
ActiveUS11377475B2High fluorescence intensity and stabilityRetain biological propertiesPolypeptide with localisation/targeting motifHydrolasesChemical reactionPhotosensitizer
The present invention refers to a protein-stabilized metal nanocluster comprising a variant of the helix A of the CTPR. It is also related to its uses for delivering of a drug, for interfering a metabolic reaction, for catalyzing a chemical reaction, as biocatalyst, for detecting an analyte, for phasing crystallographic data set, for cell labeling, for specific protein labeling, as biosensor, as a temperature sensor, as photosensitizer, or for the manufacture of an optoelectronic device.
Owner:ASOCIACION CENT DE INVESTIGACION COOP & BIOMATERIALES - CIC BIOMAGUNE
Procedure for the treatment of purines and resulting product
InactiveCN101198557ARetain biological propertiesOrganic compounds purification/separation/stabilisationSludge treatmentChemical treatmentLow nitrogen
The procedure for the treatment of purines includes a first phase (1) of electrolytic treatment of the mentioned liquid part in which the metallic nitrates are destroyed by oxidation - reduction and a second phase (2) of physical-chemical treatment of purification and alteration of the properties of the liquid part, eliminating or reducing the pollutants and the CDO; and a third phase (3) in which a substance is added for the use of the resulting product as a base in the manufacture of detergents, medicines and / or cosmetics. The resulting product is sterile, with a total reduction of the metallic nitrates, low nitrogen ammoniacal level, pH between 7.5 to 9.5 and contains phosphorus between 1.5 and 4.5 milligrams / litre, sodium between 750 and 1,800 milligrams / litre, nitrates lower than 1 milligram / litre, ammonia between 2,500 and 4,500 milligrams / litre and its maximum CDO is 5,500 milligrams / litre.
Owner:何塞普·塔皮亚斯·帕尔瑟里萨斯 +1
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