Strontium and iron doped hydroxyapatite collagen fiber composite scaffold material and preparation method thereof

Abstract

The invention discloses a strontium and iron doped hydroxyapatite collagen fiber composite scaffold material and a preparation method thereof. The scaffold material is prepared through compounding collagen fibers having a three dimensional connective porous structure with strontium and iron doped hydroxyapatite with a good drug therapy function. The preparation method mainly comprises the following steps: preparing strontium and iron doped hydroxyapatite through a co-precipitation technology; and compounding the collagen fibers through a dipping-pulling technology. The functional bone restoration scaffold material has excellent biologic performances, very good mechanical strength and toughness and a three dimensional connective macro-porous structure, can deliver drugs to a specific position under the induction of a magnetic field, can restore and treat bone defects induced by various bone diseases, and has wide application prospect in the field of bone restoration materials and biological drugs.

Description

technical field

[0001] The invention relates to the field of artificial bone repair materials and biomedicine, in particular to a strontium and iron doped hydroxyapatite / collagen fiber composite scaffold material and a preparation method thereof. Background technique

[0002] With the continuous development of biomedicine, the repair of bone defects caused by various diseases and traumas has attracted widespread attention. Due to the limited sources of natural bone and autologous bone, the development of new artificial bone repair materials has an important theory significance and application value.

[0003] Hydroxyapatite is the main inorganic component of human bones and teeth. Because of its good biocompatibility and osteoinductive ability, it can form a tight chemical bond with human bone tissue at the interface after implanted in the human body, thereby inducing bone formation. The growth of tissue promotes bone repair, and it is a good hard tissue replacement material...

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