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Strontium and iron doped hydroxyapatite collagen fiber composite scaffold material and preparation method thereof

A technology of hydroxyapatite and collagen fibers, applied in the directions of iron compounds, chemical instruments and methods, medical science, etc., to achieve the effect of promoting rapid formation, repair and treatment of bone defects, and good biological activity

Active Publication Date: 2016-05-04
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the deficiency of single bone repair material performance, and introduce certain functional particle, provide a kind of strontium, iron doped hydroxyapatite / collagen fiber composite support material and preparation method, to obtain a kind of having excellent Composite scaffold materials for bone repair with biological properties, mechanical properties, and certain drug therapy functions

Method used

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  • Strontium and iron doped hydroxyapatite collagen fiber composite scaffold material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Weigh 4gSr(NO 3 ) 2 , 61gFeCl 3 ·6H 2 O, add it to 200mL deionized water, add it into deionized water, and magnetically stir to dissolve; after it is completely dissolved, add it to 250mL60% sodium carbonate solution, control the temperature at 35°C, stir to make it co-precipitate, and then sonicate for 10min, Vacuum suction filtration, then put the filter cake in a blast drying oven, and dry at 90°C for 24 hours to obtain the precursor powder; weigh 1.0g NaCl and mix it with the precursor powder, grind it evenly, place it in a muffle furnace, and heat it at 3°C / The temperature was raised to 900°C at a speed of min, and calcined for 6 hours to obtain SrFe 12 o 19 powder.

[0031] (2) Weigh 5.54g of calcium chloride and add it to deionized water to dissolve, and make a solution of 0.3mol / L, adjust the pH of the solution to 10 with ammonia water, and then add 5.0g of SrFe prepared in step (1) 12 o 19 powder, stir evenly at room temperature; weigh 3.95g of ammo...

Embodiment 2

[0035] (1) The same as described in Example 1.

[0036] (2) Weigh 11.08g of calcium chloride and add it to deionized water to dissolve, and make a solution of 0.3mol / L, adjust the pH of the solution to 10 with ammonia water, and then add 5.0g of SrFe prepared in step (1) 12 o 19 Powder, stir evenly at room temperature; weigh 7.91g of ammonium hydrogen phosphate and add it to deionized water to dissolve, adjust the pH of the solution to 10 with ammonia water, slowly add it to the above mixed solution containing calcium chloride at room temperature, continue to stir for 1 hour, and let it stand for 12 hours , and then washed with deionized water and ethanol, dried at 80°C for 24 hours to obtain strontium and iron doped hydroxyapatite, and the prepared strontium and iron doped hydroxyapatite was ball milled at a speed of 300r / min for 10 hours, and then used.

[0037] (3) The same as described in Example 1.

Embodiment 3

[0039] (1) The same as described in Example 1.

[0040] (2) Weigh 16.61g of calcium chloride and add it to deionized water to dissolve, and make a solution of 0.3mol / L, adjust the pH of the solution to 10 with ammonia water, and then add 5.0g of SrFe prepared in step (1) 12 o 19 Powder, stir evenly at room temperature; weigh 11.86g of ammonium hydrogen phosphate and add it to deionized water to dissolve, adjust the pH of the solution to 10 with ammonia water, slowly add it to the above mixed solution containing calcium chloride at room temperature, continue stirring for 1 hour, and let it stand for 12 hours , and then washed with deionized water and ethanol, dried at 80°C for 24 hours to obtain strontium and iron doped hydroxyapatite, and the prepared strontium and iron doped hydroxyapatite was ball milled at a speed of 300r / min for 10 hours, and then used.

[0041] (3) The same as described in Example 1.

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Abstract

The invention discloses a strontium and iron doped hydroxyapatite collagen fiber composite scaffold material and a preparation method thereof. The scaffold material is prepared through compounding collagen fibers having a three dimensional connective porous structure with strontium and iron doped hydroxyapatite with a good drug therapy function. The preparation method mainly comprises the following steps: preparing strontium and iron doped hydroxyapatite through a co-precipitation technology; and compounding the collagen fibers through a dipping-pulling technology. The functional bone restoration scaffold material has excellent biologic performances, very good mechanical strength and toughness and a three dimensional connective macro-porous structure, can deliver drugs to a specific position under the induction of a magnetic field, can restore and treat bone defects induced by various bone diseases, and has wide application prospect in the field of bone restoration materials and biological drugs.

Description

technical field [0001] The invention relates to the field of artificial bone repair materials and biomedicine, in particular to a strontium and iron doped hydroxyapatite / collagen fiber composite scaffold material and a preparation method thereof. Background technique [0002] With the continuous development of biomedicine, the repair of bone defects caused by various diseases and traumas has attracted widespread attention. Due to the limited sources of natural bone and autologous bone, the development of new artificial bone repair materials has an important theory significance and application value. [0003] Hydroxyapatite is the main inorganic component of human bones and teeth. Because of its good biocompatibility and osteoinductive ability, it can form a tight chemical bond with human bone tissue at the interface after implanted in the human body, thereby inducing bone formation. The growth of tissue promotes bone repair, and it is a good hard tissue replacement material...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/54A61L27/56A61L27/58C01G49/00
Inventor 何丹农阳俊周涓张彬金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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