53 results about "Biogenic peptide" patented technology

Provided are peptide nucleic acid derivatives targeting the 5' splice site of 'exon 5' within the human androgen receptor pre-mRNA. The peptide nucleic acid derivatives potently induce splice variantsof the androgen receptor mRNA in cells, and are useful to safely treat dermatological indications or conditions involving androgenic activity upon topical administration.

The present invention relates to a novel glucagon derivative peptide, and a composition for preventing or treating hypoglycemia containing the novel glucagon derivative peptide as an active ingredient. The glucagon derivative according to the present invention has improved physical properties due to the change in isoelectric point (pI) while being capable of maintaining an activity on glucagon receptors, and thus can improve patient compliance when used as a hypoglycemic agent, and is also suitable for administration in combination with other anti-obesity agents. Accordingly, the glucagon derivative according to the present invention can be effectively used for the prevention and treatment of hypoglycemia and obesity.

The invention relates to a method for producing a high-efficiency biological peptide through enzymolysis and microbe fermentation, which comprises the following steps of: smashing a fermentation substrate, uniformly mixing, then adding water for material blending, and then cooking and sterilizing; when temperature is reduced to 50-55 DEG C, adding a proteolytic enzyme for hydrolyzation; after the hydrolyzation is finished, when the temperature is reduced to 28-35 DEG C, adding a mixed bacterium solution to the hydrolyzed fermentation substrate, uniformity stirring, and carrying out aerobic fermentation under the condition of constant temperature; and carrying out low-temperature drying on the fermented materials, and then smashing to obtain a high-efficiency biological peptide finished product. The fermentation substrate comprises the following materials in parts by weight: 50-60 parts of high-protein bean pulp, 10-20 parts of glutamic acid bacterial protein and 30-40 parts of dephenolized cottonseed protein, and the components are smashed and screened through a 40-mesh screen and then uniformly mixed. The mixed bacterium solution is obtained by mixing the bacterium solutions of aspergillus niger, candida tropicalis, aspergillus oryzae and bacillus subtilis according to the proportion of 1:1:1:1, and the mixed bacterium solution is inoculated into the hydrolyzed fermentation substrate in 5%-10% by weight.