The invention discloses a Zhuang pharmaceutical composition for treating anovulatory infertility. Raw materials of the Zhuang pharmaceutical composition comprise, by weight, 10-50 parts of radix fici simplicissimae, 10-40 parts of polygala fallax hemsl, 10-30 parts of Talinum crassifolium, 10-30 parts of semen cuscutae, 10-30 parts of tortoise-shell glue, 10-25 parts of morinda officinalis, 10-25 parts of Embelia parviflora, 10-30 parts of radix rehmanniae preparata, 10-30 parts of wolfberry, 10-30 parts of raspberry, 10-30 parts of amethyst and 10-30 parts of honey-fried licorice root. A preparation method of the Zhuang pharmaceutical composition comprises the following steps: respectively weighing raw materials by weight portion, cleaning and selecting, adding water and immersing; decocting for first time: cooking to ebullition under strong fire and cooking under slow fire for 20-25 min, and filtering out a liquid medicine; decocting for the second time: adding room temperature water, cooking to ebullition under strong fire and cooking under slow fire for 15-20 min, and filtering out a liquid medicine; and merging the two liquid medicines obtained by the first decoction and the second decoction. The composition provided by the invention has effects of regulating qi, dispelling dampness, regulating internal heat, tonifying the kidney and easing liver, has functions of promoting ovulation and improving symptoms such as palpitation and insomnia, soreness of loins and knees, clear abundant urine and discomfort in chest and hypochondrium, has definite, rapid and stable curative effects, and has no toxic or side effect.