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Application of Talinum paniculatum (Jacq.) Gaertn. polysaccharide on aspect of accelerating dissolving of baicalin in water, and method

The technology of red ginseng polysaccharide and ginseng polysaccharide is applied in the application field of red ginseng polysaccharide in promoting the dissolution of baicalin in water, and can solve the problems of intestinal wall damage, hidden danger of medication safety, leakage of phospholipid compound drugs, etc., and achieves broad application prospects , The effect of improving solubility and high development value

Pending Publication Date: 2021-07-23
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, any technology has its limitations, and different technologies have different scopes of application, and there are also defects.
For example, surfactant compounds widely used in nanometer, self-microemulsion, and liquid preparations can dissolve intestinal mucosa, and may cause damage to the intestinal wall when the content is high, aggravating drug side effects and causing drug safety hazards; phospholipid complexes exist The problem of drug leakage and poor stability; the addition of some co-solvents will affect the absorption or stability of the drug, and increase the irritation or toxicity of the preparation
Solid dispersions have the tendency of drug crystal form to change from unstable to stable and aging problems of preparations; nanosuspensions have problems of poor stability, and cyclodextrins have problems such as low drug loading and specific requirements for drug molecular size

Method used

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  • Application of Talinum paniculatum (Jacq.) Gaertn. polysaccharide on aspect of accelerating dissolving of baicalin in water, and method
  • Application of Talinum paniculatum (Jacq.) Gaertn. polysaccharide on aspect of accelerating dissolving of baicalin in water, and method
  • Application of Talinum paniculatum (Jacq.) Gaertn. polysaccharide on aspect of accelerating dissolving of baicalin in water, and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0047] Example 2 Red ginseng polysaccharide increased the degree of solubility of baicalin composition

[0048] Determination of balanced solubility: Take ionin 2mg in 2 ml of centrifuge tube, 2 parts of parallel, add 1 ml of concentration of 5% red ginseng polysaccharide solution (with pure water as blank solvent), vortex 2min, centrifuge, and place in 37 Cove in the rice cooker in the rice cooker 24h so that it fully reaches the balance. The sample was taken off to room temperature, and 12000 rpm was centrifuged for 10 min, precision absorption of 0.2 mL of the supernatant, placed in a new 2 ml of centrifuge tube, add 0.8 ml of methanol to precipitate polysaccharide, and the polysaccharide is completely precipitated, 12000 rpm Centrifuge 10 min, 12000 rpm Take the supernatant, a 0.45 μm filter, injected into HPLC, and assay.

[0049] Solubility assay: Column: Agilent Eclipse XDB C18 (4.6 * 250mm, 5μm); mobile phase: A-methanol, B-0.1% phosphoric acid; flow rate: 1 mL / min, colu...

Embodiment 3

[0053] Effect of Example 3 Red Paramemic Polysaccharide with Polysin Comparisons on Solubility

[0054] like Image 6 The baicalin component 2 mg in 2 ml of centrifuge tube, according to the baicide: polysaccharide ratio of 1: 160, 1: 80, 1: 40, 1: 20, 1: 10, 1: 5, 1: 2.5, 1: 1.25, 1: 0.625, 1: 0.3125 Add red gamfrangosaccharide, (with pure water as a white solvent), vortex 2min, the centrifuge is sealed in a 37 ° C water bath, so that it makes it sufficient to equilibrate. The sample was taken off to room temperature, and 12000 rpm was centrifuged for 10 min, precision absorption of 0.2 mL of the supernatant, placed in a new 2 ml of centrifuge tube, add 0.8 ml of methanol to precipitate polysaccharide, and the polysaccharide is completely precipitated, 12000 rpm Centrifuge 10 min, 12000 rpm Take the supernatant, a 0.45 μm filter, injected into HPLC, and assay.

[0055] The results showed that the solubility of the baicalin increased significantly with the ratio of the polysacchari...

Embodiment 4

[0056] Effect of Example 4 Red Paramemic Polysaccharide on Stability of Baricalin Composition

[0057] In order to assess the stability of individual baicalins and BAI-RGP (1: 5, 1: 10, 1: 20), three different pH (1.2, 6.8 and 8.3) are used to simulate stomach, small intestine and large intestine. environment. 2 mg of baicalin was placed in a 10 ml brown volumetric flask, and then pH 1.2, pH 6.8 or pH 8.3 was added, vortex for 2 minutes, and the initial concentration was determined using the established HPLC method (C 0 ). For BAI-RGP group, 2 mg of baicalin and corresponding amount of RGP is added, and the remaining concentration is measured at different time points (C t ). Related parameters of baicalin and BAI-RGP in different pH conditions, including table optometry constants (kobs), very unsained period (T 0.9 ) And half-life (T 0.5 ), Chemical dynamics equation.

[0058] The result shows that Figure 8 And Table 2 shows, Time (T) is in (C t / C 0 ) Linear regression gains deg...

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Abstract

The invention discloses application of Talinum paniculatum (Jacq.) Gaertn. polysaccharide on an aspect of accelerating dissolving of baicalin in water, and a method, and belongs to the medicine field. The method is characterized in that the Talinum paniculatum (Jacq.) Gaertn. polysaccharide and the baicalin are evenly mixed in water to improve the solubility of the baicalin in the water. The polysaccharide has a wide source, utilization of the polysaccharide for solubilizing the baicalin which is an insoluble component is reported for the first time, and compared with other solubilizing ways, the invention has the advantages of being simple in operation, high in reliability and the like.

Description

Technical field [0001] The present invention relates to the field of medicine, and more particularly to the use and methods of red ginseng polysaccharide in promoting dissolution in water in water. Background technique [0002] In traditional drugs, Chinese herbal medicines have reached thousands of years in clinical use. The treatment of traditional Chinese medicine has the advantages of less side effects and low toxicity. It can have a more comprehensive and stereotype of the disease through its unique multi-target effect, especially in the unique side of the suspicity, and it is not alternative to Western medicine. effect. A large number of studies have shown that flavonoids have strong bioactive, and traditional Chinese medicine rich in flavonoids has been widely used in clinics. Astragus is a famous Chinese herbal medicine containing more than 40 flavonoids. Since the Han Dynasty, Astragalus has been regarded as a gold herb being applied in many ways, which mainly exerts 6 c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K31/7048A61K36/539A61P29/00A61P39/06A61P35/00A61P31/12C08B37/00
CPCA61K47/36A61K31/7048A61K36/539A61P29/00A61P39/06A61P35/00A61P31/12C08B37/006C08B37/0003
Inventor 贾晓斌廉源沛封亮
Owner CHINA PHARM UNIV
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