Orally disintegrating tablet containing fexofenadine or salts of fexofenadine, and preparation method thereof
A technology of orally disintegrating tablets and fexofenadine, which is applied in the direction of non-active ingredient medical preparations, pharmaceutical formulations, active ingredients of heterocyclic compounds, etc., can solve the problem of increased incidence of cardiotoxicity, poor selectivity, application limitations, etc. question
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Embodiment 1
[0020] Preparation Process:
[0021] Disperse the acrylic resin E100 in the prescribed amount of 95% ethanol; after dispersing evenly, add the prescribed amount of fexofenadine hydrochloride, stir for 30 minutes to make it completely dissolve; evaporate at 50 degrees for about 3 hours to obtain fexofenadine hydrochloride Definite clathrate. Weigh the fexofenadine inclusion compound of prescription quantity, add mannitol, starch, ethyl cellulose and croscarmellose sodium in equal amounts and mix evenly; use starch slurry as binder to make soft material, 16-mesh granulation; blast drying at 50 degrees, granulation with 24-mesh sieve; add prescription amount of croscarmellose sodium starch and magnesium stearate, mix evenly; compress into tablets.
Embodiment 2
[0024] Preparation Process:
[0025] Disperse the acrylic resin E100 in the prescribed amount of 95% ethanol; after dispersing evenly, add the prescribed amount of fexofenadine hydrochloride, stir for 30 minutes to make it completely dissolve; evaporate at 50 degrees for about 3 hours to obtain fexofenadine hydrochloride Definite clathrate. Weigh the prescribed amount of fexofenadine inclusion compound, add mannitol, starch, ethyl cellulose and hydroxypropyl cellulose in equal amounts and mix evenly; use starch slurry as a binder to make a soft material, 16 mesh Granules; air-dried at 50 degrees, granulated with a 24-mesh sieve; plus the prescribed amount of croscarmellose sodium starch and magnesium stearate, mixed evenly; compressed into tablets.
Embodiment 3
1
[0029] Preparation Process:
[0030] Disperse the acrylic resin RSOP in the prescribed amount of 95% ethanol; after dispersing evenly, add the prescribed amount of fexofenadine hydrochloride, stir for 30 minutes to make it completely dissolve; rotate and evaporate at 50 degrees for about 3 hours to obtain fexofenadine hydrochloride Definite clathrate. Weigh the prescribed amount of fexofenadine inclusion compound, add mannitol, starch, ethyl cellulose and hydroxypropyl cellulose in equal amounts and mix evenly; use starch slurry as a binder to make a soft material, 16 mesh Granules; air-dried at 50 degrees, granulated with a 24-mesh sieve; plus the prescribed amount of hydroxypropyl cellulose and magnesium stearate, mixed evenly; compressed into tablets.
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