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Medical composition of antibiotic and pidotimod as well as preparation method and medical application thereof

A technology of antibiotics and compositions, applied in the field of medicine, can solve the problems of bacterial drug resistance, refractory infection, and insufficient to completely eliminate pathogenic bacteria.

Inactive Publication Date: 2010-01-13
杨喜鸿
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Bacterial infection is a common problem encountered in clinical medicine. Various antibiotics are used clinically to prevent and treat bacterial infections. Antibiotics have become widely used drugs in clinical practice. However, long-term and high-dose use of antibiotics will produce bacterial resistance, making Clinicians often face problems such as refractory infection and recurrent infection. Therefore, improving the antibacterial efficacy of antibiotics and reducing the amount or cycle of antibiotic use are of great significance for the use of antibiotics and disease treatment
[0003] Studies have found that the immune response exists during the occurrence and development of bacterial infection. When suffering from bacterial infection, it is easy to cause different degrees of immune deficiency, and immune deficiency can aggravate the disease and form a vicious circle. In a low state, relying solely on exogenous antibacterial drugs is not enough to completely eliminate pathogenic bacteria, and it is easy to leave hidden dangers of inducing drug resistance

Method used

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  • Medical composition of antibiotic and pidotimod as well as preparation method and medical application thereof
  • Medical composition of antibiotic and pidotimod as well as preparation method and medical application thereof
  • Medical composition of antibiotic and pidotimod as well as preparation method and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0172] Embodiment 1. Cefodizime sodium pidotimod powder injection for injection (1: 0.15)

[0173] Prescription (1000 sticks): cefodizime sodium 1000g, pidotimod 150g, arginine 37g, sodium metabisulfite 12g.

[0174] Preparation method: pre-process the above materials into sterile powder, mix cefodizime sodium, pidotimod, arginine and sodium metabisulfite uniformly under aseptic conditions, and aseptically pack into 1000 tubes to obtain injection Use cefodizime sodium pidotimod powder injection for injection, each containing cefodizime sodium 1g and pidotimod 0.15g (1:0.15), for injection, the powder injection can be dissolved in normal saline when used After intravenous infusion.

Embodiment 2

[0175] Embodiment 2. The compound injection powder injection of other cephalosporin antibiotics and pidotimod

[0176] Similar to Example 1, the compound powder injections of the following 17 kinds of antibiotics and pidotimod are respectively provided based on the prescription amount of 1 injection, for example as follows:

[0177] Compound powder injection name (proportion)

[0178] (1∶0.2)

[0179] Preparation method: Separately, the above-mentioned materials are made into sterile powder in advance, the raw and auxiliary materials are mixed evenly under aseptic conditions, and aseptically divided into 1 tube, and the injection powder of the above-mentioned antibiotics and pidotimod ( compound), for injection use, the powder injection can be dissolved with physiological saline or 0.5% glucose injection for intravenous injection.

Embodiment 3

[0180] Embodiment 3. the compound preparation of oral cephalosporin antibiotics and pidotimod

[0181] Based on the prescription volume of 1,000 units of preparations, the following 12 kinds of compound oral preparations of cephalosporin antibiotics and pidotimod are provided, examples are as follows:

[0182] Oral agent name

[0183] Preparation method: respectively, according to the prescription amount and the dosage form of the preparation, select suitable pharmaceutical excipients, mix the pharmaceutical excipients of the prescription amount with cephalosporin antibiotics, pidotimod or its intermediate preparations, and prepare according to the preparation method of conventional preparations. method, the desired oral formulations can be obtained.

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Abstract

The invention relates to a medical composition which is composed by antibiotic and pidotimod by the mass ratio of 1:0.01-15. The medical composition can be composed by the antibiotic and the pidotimod which are both compound preparation or by the antibiotic and the pidotimod which are independent medical preparation and are packaged in the same medicine box. The medical composition has the advantages that if the pidotimod or the derived salt thereof which is immunopotentiator can be supplied when the antibiotic is used for treating the bacterial infection, the treating effect of the antibiotic can be well improved, the antibiotic and the pidotimod can take effect synergistically, and the use amount of the antibiotic is reduced or the use period is shortened. The invention further discloses the preparation method and the medical application of the medical composition.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition of antibiotics and pidotimod, a preparation method and pharmaceutical application thereof. Background technique [0002] Bacterial infection is a common problem encountered in clinical medicine. Various antibiotics are used clinically to prevent and treat bacterial infections. Antibiotics have become widely used drugs in clinical practice. However, long-term and high-dose use of antibiotics will produce bacterial resistance, making Clinicians often face problems such as refractory infection and recurrent infection. Therefore, improving the antibacterial efficacy of antibiotics and reducing the amount or cycle of antibiotic use are of great significance for the use of antibiotics and disease treatment. [0003] Studies have found that the immune response exists during the occurrence and development of bacterial infection. When suffering from bacterial i...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/427A61P31/04
Inventor 杨喜鸿
Owner 杨喜鸿
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