233 results about "Antibiotic use" patented technology

The invention relates to an anaerobic micro-ecological system, a composition comprising anaerobically cultivated human intestinal microbiota for the treatment or prophylaxis of diseases, and wherein the microbiota in the composition have not been exposed to antibiotics used after 1995. The present invention further relates to the use of the composition for the prevention and treatment of disease and a method for preparing the composition.

The invention discloses a fermented Chinese herbal medicine feed additive for aquatic products. The fermented Chinese herbal medicine feed additive for aquatic products has various functions of prevention, health-care, treatment, immunoregulation and the like, and is an ideal, green, environment-friendly and safe novel feed additive which can replace antibiotic medicines. The fermented Chinese herbal medicine feed additive is prepared from compound Chinese herbal medicines through a process of Chinese herbal medicine ultrasonic-assisted extraction and multi-strain two-step fermentation, and has double advantages of Chinese herbal medicines and probiotics, so that the additive can efficiently regulate the intestinal health of aquatic animals, treat both symptoms and root causes, consolidate basis, maintain the microecological balance and optimal immune state of the intestinal tract, improve the digestibility of nutrient substances, the immunity of animal bodies and the breeding income, reduce the breeding risk and replace antibiotics, is free from harmful effect to aquatic animals, safe to use and free from problems of medicine residue and tolerance, and has a wide market prospect.

The invention belongs to the technical field of detection of enrichment of remained antibiotics in a water body environment, and particularly relates to a synchronous detection method of tetracyclines, fluoroquinolones and sulfonamide antibiotics remained in the water body. The detection method comprises the following steps: (1) performing water sample pretreatment; (2) performing small-column enrichment of target antibiotics by using solid-phase extraction; (3) detecting on a machine by using high performance liquid chromatography and tandem mass spectrum. According to the method, once the sample feeding is carried out at one time, multiple antibiotics in the water body can be detected at the same time, the time consumption of a detection process is reduced, the detection accuracy and sensitivity are increased, the detection limit is low, and the condition of the trace amount of remained antibiotics in the water body environment can be detected; meanwhile, the detection method is convenient to operate and low in environment toxicity and is low in using amount of organic reagents.

The invention discloses a fermented Chinese herbal immunopotentiator used for snakeheads. With the efficacy of prevention, health care, treatment and immunoregulation, the Chinese herbal immunopotentiator is an ideal, green, environmental friendly, safe and novel feed additive for substituting antibiotic drugs. The fermented Chinese herbal feed additive is prepared by subjecting compound Chinese herbal medicines to a process of ''ultrasonic wave assisted extraction of Chinese herbal medicines and multi-strain two-step fermentation'', has the advantages of both Chinese herbal medicines and probiotics, can efficiently condition the intestinal health of snakeheads, treat both symptoms and root causes, consolidate the basis and foster vitality, maintain intestinal microecological balance and an optimal immune state, improves the digestibility of nutrients, improves the body immunity of snakeheads, improves farming profits, and reduces farming risk. The Chinese herbal immunopotentiator can be used for replacing antibiotics, has no adverse effect on snakeheads, is safe to use, and is free of drug residue, drug resistance and other problems, thus having broad market prospects.

Antibiotics used to cure Uterine Tract Infections have resulted in the growth of MRSA. and other antibiotic resistant bacteria. The CDC guidelines state “Disposable diapers cause 95% of all UTI'S”. The procedures used for “prevention” are ineffective because millions of bacteria in incontinence garments continue to double every 20 minutes. Silver ions in bandages are used to cure severly damaged skin, such as in burns. The best two in a large scale test achieved results in just 30 minutes. This Invention uses silver ions in linings next to the skin to stop the growth of over 250 kinds of infectious bacteria on it's surface and the body parts it touches. It achieves results in 30 minutes, equal to the most highly rated bandages . . . for every level of incontinence for both sexes.

The invention discloses a fermentation type Chinese herbal medicine immunoenhancer used for channel catfish. The fermentation type Chinese herbal medicine immunoenhancer used for the channel catfish has multiple effects of prevention, healthcare, treatment, immune adjustment and the like, and is an ideal green environmental-friendly safe novel feed additive capable of replacing antibiotics. The fermentation type Chinese herbal medicine additive is prepared from compound Chinese herbal medicines through the processes of ultrasonic-assisted extraction of the Chinese herbal medicines, as well as aerobic fermentation and anaerobic fermentation combined secondary fermentation of multi-strains, has the double advantages of the Chinese herbal medicines and probiotics, efficiently adjusts the intestinal health of the channel catfish, treats both manifestation and root cause of diseases, consolidates basis, keeps microecological balance of the intestinal tract and the best immune state, improves the digestion and absorption rates of nutrient substances, improves the immunity of the channel catfish and the cultivation benefit, reduces the cultivation risk, replaces the antibiotics, has no bad influences on the channel catfish, is safe to use, does not have the problems of drug residues, tolerance and the like, and has a wide market prospect.

The invention discloses a fermented type Chinese herbal medicine immunological enhancer for finless eel, which has a plurality of effects of prevention, health care, treatment, immune regulation and the like, and is an ideal, green, environment-friendly, safe and novel feed additive for substituting antibiotics medicaments. The fermented type Chinese herbal medicine feed additive is prepared from compound Chinese herbal medicines through processes of Chinese herbal medicine ultrasonic-assisted extraction and multi-strain two-step fermentation, has double advantages of the Chinese herbal medicines and probiotics, can effectively regulate intestinal health of the finless eel, can treat both symptoms and root causes, can supporting the healthy energy and cultivate vigor, can keep intestinal tract microecological balance and the optimal immune state, can improve digestibility of nutrition substances, can improve immunity of the finless eel body, can increase breeding income, can lower breeding risks, can substitute antibiotics in use, has no bad influences on the finless eel, and is safe to use and free from problems such as medicine residue and medicament resistance, has a wide market prospect.

The invention relates to a clostridium butyricum strain used for feeding, and an application thereof. The provided clostridium butyricum B1 CGMCC No. 4845 is a Gram-positive rod. When observed by using an optical microscope, the sizes of the strains are (0.6-1.2)mum*(3.0-7.0)mum; the ends of the strains are round; the middle parts of the strains are slightly bulged; the strains are single or in couples; the strains are short-chained; filamentous thallus with peritrichous is occurred; the strains are movable; the spores are egg-shaped, and are grew decentrically or on the minor ends; the strains form white or cream-colored small-scaled round colonies on an anaerobic agarose plate; the strains grow under an anaerobic condition, with a growth temperature range of 20 DEG C to 60 DEG C, and preferably 30 DEG C to 42 DEG C; the growth hydrogen power range of the strains is pH 2-10, and preferably pH 7.0. Microbial manure prepared with the strains brings no toxin and harm, and is gastric juice resistant and bile salt resistant. The microbial manure provides strong inhibiting effects against various harmful bacteria. Therefore, the strains can be widely applied in poultry and livestock cultivation industries. With the strain, animal disease resistance can be improved. The strain has potential to be applied as a substitution of antibiotics used for feeding.

The invention discloses a core material of feed for a baby pig. The core material comprises the following substances in parts by weight: 3-18 parts of plant essential oil, 6-20 parts of complex multiple ore, 6-20 parts of active factor, 6-24 parts of skimmed milk powder, 2-12 parts of antibacterial peptide, 2-10 parts of an acidifier and 1-8 parts of an edulcorant. The core material of the feed for the baby pig, which is provided by the invention, does not contain any antibiotic drug, avoids problems of drug remaining and drug tolerance which are caused by an antibiotic, improves the pollution to an environment and soil, and improves the quality and the safety of meat; a ration feeding effect can also replace an antibiotic using effect; the demands of the normal growth and a nutrient substance of the baby pig are completely met.

The invention discloses in-vitro tissue preserving fluid and a preparation method thereof. Each 1,000 milliliters of preserving fluid comprises the following components by weight: 5 to 200 grams of osmotic pressure regulator, 0.2 to 40 grams of a pH value buffer pair, 3 to 15 grams of potassium chloride, 1 to 5 grams of sodium chloride, 10 to 300 milligrams of antibiotic, 5 to 100 grams of glucose and the balance of deionized water. In the invention, a non-CO2 dependent buffer pair is used to reduce the dependence on CO2 in transport and an air exposure process and reduce the fluctuations of the pH value; a hypertonic and high-potassium environment is used to reduce the swelling of cells and tissues and improve the activities of the cells and tissues; and the antibiotic used is free from causing hypersensitivity reaction. The preparation method is simple and in-vitro tissue preserving fluid has a remarkable in-vitro tissue preserving effect. The in-vitro tissue preserving fluid is low in cost, has low transport requirements, and can be stored at room temperature and conveniently.

An apparatus and method for treating or preventing bacterial colonization of medical devices, or the host itself, comprise combining an RNAIII inhibiting peptide (RIP) with the medical device, optionally with an antibiotic. Further, RIP may be used in a lock technique, comprising adding sufficient solution comprising RIP to occupy a space within the device, which provides a high concentration of RIP at the actual or potential site of infection and prevents the space from filing with blood. The invention thus allows a clinician to maximize the amount of RIP and an antibiotic used to clean the medical device, while, at the same time, retaining the device within the host.

The invention discloses a method for immobilizing a natural antibacterial agent. The method comprises the following steps: firstly preparing an attapulgite-based composite nanostructure carrier material, then sequentially dispersing the carrier material and the natural antibacterial agent into a certain ratio of ethanol aqueous solution under mechanical stirring and ultrasonication conditions, andthen shocking, centrifuging and drying at constant temperature, thus obtaining the attapulgite-based composite nanostructure carrier material. The method disclosed by the invention has the advantagesof cheap and available raw materials and simple operation, and the obtained nano composite antibacterial agent not only has broad-spectrum antibacterial property but also has high thermal stability and antibacterial persistence, is an antibacterial product respectively taking effect during storage and use of feed as a feed additive and can replace antibiotics used in an animal breeding process for a long time.

The invention provides Lactobacillus salivarius M6, which is preserved in the China General Microbiological Culture Collection Center (CGMCC) with the number of CGMCC 3505. The invention also provides a lactobacillus which can be mixed with animal feed or added into water, can be used together with antibiotics at the same time, and has antibiotic resistance. The strain can inhibit growth of Salmonella enterica, Escherichia coli and other pathogenic bacteria. The antibacterial composition of the Lactobacillus salivarius M6 can be used in drinking water, drinking water additives, feed and food additives of animals, human and animal medical composition, as well as drinks, drinking additives, foods, food additives and the like of humans. By implementation of the invention, pathogenic bacterium infection of animals or humans can be effectively prevented and treated, and the number of intestinal probiotics can be increased or maintained, so that the growth of pathogenic bacteria is inhibited, the dosage of antibiotics is reduced, and the aim of preventing disease infection of animals and humans can be achieved.

The invention relates to a feed additive for preventing dairy cow mastitis. The feed additive is prepared from the following components in parts by weight: 5-10 parts of medlar, 15-20 parts of Chinese dates, 5-8 parts of flowers carthami, 5-8 parts of chrysanthemum, 2-4 parts of radix paeoniae alba, 8-12 parts of polygonum multiflorum, 2-4 parts of smoked plum, 1-3 parts of yeast culture, 2-4 parts of medicinal stones and 3-5 parts of bentonite. The feed additive disclosed by the invention can be used for preventing the dairy cow mastitis effectively, so that the health condition of dairy cow is improved, and the effects on the milk yield and the quality of a dairy product due to diseases such as mastitis are avoided. By virtue of the feed additive disclosed by the invention, the economic benefits of cow cultivation are greatly improved, and the adverse effects on the quality of the dairy product and the health of the dairy cow caused by antibiotics can be avoided.

The invention discloses an antibacterial immune double-effect compound Chinese herb for skin ulcerative syndrome of apostichopus japonicus. The herb comprises the following components: common andrographis herb, dyer woad leaf, honeysuckle and szechuan lovage rhizome; the weight ratio of the components is 2:1:3:2; and the herb is powered, wherein granularity is 200 mesh. The herb is orally taken to prevent and cure the skin ulcerative syndrome of apostichopus japonicus, wherein each kilogram feed is added with 20g of herb powder for the mild sea cucumber and each kilogram feed is added with 30g of herb powder for the critical sea cucumber. When in use, the herb is weighed according to required dosage and is fed after being evenly stirred with stichopus japonicus feed one time per day, wherein continues 20 days are a period of treatment. The Chinese herb is special for the skin ulcerative syndrome of apostichopus japonicus, which can be used for the young sea cucumbers and the adult sea cucumbers, has good protection effect during the peak period of the skin ulcerative syndrome, and has cure rate high to 80-90% and survival rate high to more than 85% for the apostichopus japonicus having the skin ulcerative syndrome within 2-3 weeks. The compound herb has a double effect for immunity and disease resistance, has no poison and side effect, convenient use, can reduce or replace the use of antibiotics, and is suitable for breeding the young sea cucumbers and controlling diseases during breeding and producing.

The invention relates to the technical field of pig breeding, in particular to an ecological pig breeding method. The ecological pig breeding method includes the steps of timely mating, wherein stock boars are reasonably utilized; pigpen management, wherein a fermentation bed technology is adopted for improving the external environment of a farm; feeding management, wherein ecological pig feed is used for feeding pigs in a pigpen until the pigs are slaughtered; disease prevention management, wherein the pigs are subjected to injection immunization in spring and autumn, parasite expelling and environment disinfection are conducted periodically, and the pigs are fed with antiviral traditional Chinese medicine pills regularly; timely slaughtering. By means of the ecological pig breeding method, the immunity of the pigs can be enhanced, the viral infection rate can be reduced, and the antibiotic use level and drug residues can be reduced. By the adoption of Chinese herbal medicine additives, the antiviral traditional Chinese medicine pills have a heat-clearing and detoxicating effect and an obvious antiviral effect, have an obvious inhibiting effect on epidemic diarrhea, porcine reproductive and respiratory syndromes, influenza virus pneumonia and the like, and can replace traditional antibiotics and reduce drug residues.

The invention discloses a fermented Chinese herbal immunopotentiator for Salmo trutta marmoratus. The fermented Chinese herbal immunopotentiator has various effects such as prevention, healthcare, treatment, immunoregulation and the like so as to be a novel ideal green safe feed additive capable of substituting antibiotic drugs. The fermented Chinese herbal feed additive is prepared from a compound Chinese herbal medicine through a process comprising the steps: carrying out ultrasonic-assisted extraction on a Chinese herbal medicine, and carrying out two-step fermentation on multiple strains, so that the fermented Chinese herbal feed additive has double advantages of the Chinese herbal medicine and probiotics and can be used for efficiently regulating the intestinal health of the Salmo trutta marmoratus, treating both symptoms and root causes, consolidating the basis, keeping the intestinal microecology balanced and in the optimal immune state, increasing the digestibility of nutrient substances, improving the immunity of the organism of the Salmo trutta marmoratus, increasing the breeding income and reducing the breeding risk; and the fermented Chinese herbal immunopotentiator is used for replacing antibiotics and is free of adverse effects to the Salmo trutta marmoratus, safe in use and free of the problems such as drug residues, drug resistance and the like so as to have a wide market prospect.

The invention discloses high-temperature and high-humidity resistant saccharomyces boulardii and application thereof, and belongs to the field of microorganisms. The preservation number of the high-temperature and high-humidity resistant saccharomyces boulardii disclosed by the invention is CGMCC No.10381; the multiplication rate and maximal biomass (namely final density of thallus) of saccharomyces boulardii strains are significantly higher than those of similar saccharomyces cerevisiae strains; the saccharomyces boulardii has high heat-resistant and moisture-resistant capacities; the saccharomyces boulardii disclosed by the invention can be used as a feed additive; and relatively high activity is stored in the high-temperature and high-humidity treatment processes. According to a saccharomyces boulardii capsule, daily gain, immune organ index, disease resistance, oxidation resistance and immune globulin of broiler chicken can be improved; the saccharomyces boulardii is free of a toxic or side effect on beasts and birds, wide in source and low in price, and can be used as a feed additive instead of antibiotics.

The invention provides a composite microbial feed additive for chicken, which is characterized by comprising probiotics and prebiotics, wherein the probiotics comprise bifidobacterium, lactobacillus acidophilus, enterococcus faecium and bacillus licheniformis; and the prebiotics comprise xylooligosaccharides. The invention also provides a preparation method of the composite microbial feed additive for the chicken. The composite microbial feed additive has the advantages of reducing the morbidity of the chicken effectively, improving daily gain and feed-weight ratio effectively, reducing the production cost, reducing the usage amount of antibiotics effectively and improving the quality of animal byproducts.