Immunologic stimulant oral syrup and preparation method thereof

A technology of immunostimulants and syrups, which is applied in the field of immunostimulants oral syrups and its production, and can solve problems such as difficult quality control, low bioavailability, and inconvenient use

Active Publication Date: 2011-08-31
GUANGDONG SHUNFENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Currently, the clinically used immune function enhancers are mainly biopharmaceuticals, such as immunoglobulin, interferon, interleukin II, transfer factor or thymosin, etc., as well as plant-derived drugs, such as ginseng, astragalus, schisandra, wolfberry , Codonopsis, Cordyceps, Ganoderma lucidum and tremella polysaccharides have the effect of improving immune function. These two types of drugs have their own shortcomings, such as interferon can cause leukopenia, anemia, fever, abnormal liver function and central nervous system toxicity. Toxic and side effects, these biopharmaceuticals are mostly extracted from human blood, the source is not easy, there is a risk of exogenous infection, and most of them are injection drugs, which is inconvenient to use
However, plant-derived drugs generally have shortcomings such as slow action, poor reproducibility in industrial production, difficult quality control, and low bioavailability, which limit their wide application.

Method used

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  • Immunologic stimulant oral syrup and preparation method thereof
  • Immunologic stimulant oral syrup and preparation method thereof
  • Immunologic stimulant oral syrup and preparation method thereof

Examples

Experimental program
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Effect test

no. 1 example

[0062] The immunostimulant oral syrup is made of the following raw materials in parts by weight per 100 ml: pidotimod, 2-8g; sucrose, 35-65g; pH regulator, 0.5-1.5g; ethylparaben, 0.02~0.06g; ethanol, 0.6~1.8g; essence, 0.01~0.08g, the balance is purified water.

[0063] In order to achieve a better effect, every 100ml of the oral syrup of immunostimulants can be made of the following raw materials in parts by weight: pidotimod, 3-5g; sucrose, 40-55g; pH regulator, 0.6-1.2 g; ethylparaben, 0.03-0.05g; ethanol, 0.9-1.3g; essence, 0.012-0.03g, and the balance is purified water.

[0064] Above-mentioned pH adjusting agent is any one in anhydrous sodium carbonate, sodium carbonate, sodium hydroxide and sodium bicarbonate.

[0065] The above-mentioned essence is any one of ethyl maltol, lemon essence, banana essence, grapefruit essence and orange essence.

[0066] In this embodiment, every 100 ml of the immunostimulant oral syrup is made of the following raw materials in parts by...

no. 2 example

[0073] In this example, every 100 milliliters of the drug is made of the following raw materials in parts by weight: pidotimod, 4 g; sucrose, 45 g; anhydrous sodium carbonate, 0.9-1.2 g; ethylparaben, 0.04 g; ethanol , 1.0g; grapefruit essence, 0.02g; the balance is purified water.

[0074] Production includes the following steps:

[0075] Step 1): First, weigh each raw material according to the above-mentioned parts by weight; then add sucrose into 20 ml of purified water, stir and heat until boiling, so that the sucrose is completely dissolved into syrup, cool to below 60°C, and filter for later use;

[0076] Step 2): Anhydrous sodium carbonate is made into a 1mol / L solution with purified water, and the solution is used for subsequent use;

[0077] Step 3): adding ethylparaben to ethanol, fully stirring to completely dissolve the ethylparaben to obtain a solution, and set the solution for later use;

[0078] Step 4): first add pidotimod into 20 ml of purified water, heat a...

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Abstract

The invention relates to immunologic stimulant oral syrup and a preparation method thereof. Each 100ml of immunologic stimulant oral syrup is prepared from the following raw materials by weight: 2 to 8g of pidotimod, 35 to 65g of sucrose, 0.5 to 1.5g of pH regulator, 0.02 to 0.06g of ethyl hydroxy benzoate, 0.6 to 1.8g of ethanol, 0.01 to 0.08g of essence and the balance of purified water, wherein the PH regulator is any one of anhydrous sodium carbonate, sodium carbonate, sodium hydroxide and sodium bicarbonate; and the essence is any one of ethyl maltol, lemon essence, banana essence, grapefruit essence and orange essence. The immunologic stimulant oral syrup has the characteristics of quick response, sweeter taste and better mouthfeel, is convenient to take and is particularly suitable for oral administration of infants and the elderly with low immune functions.

Description

technical field [0001] The invention relates to an immunostimulant oral syrup and a preparation method thereof. Background technique [0002] The immune system is the most effective weapon for the human body to defend against the invasion of pathogens (such as bacteria or viruses, etc.), to prevent the occurrence of diseases and maintain the health of the human body; Stability of the internal environment of the body; identification and elimination of abnormal cells produced in the human body at any time, such as tumor cells. When the immunity is low, it will reduce the body's ability to resist foreign invasion, mainly manifested as easy fatigue, frequent colds or other diseases. As for the group most affected by low immunity, infants and young children are the most vulnerable group to be attacked by pathogens due to low immunity. In addition, as the age increases, the immune organs will undergo physiological degeneration, especially the thymus gland. The thymus gland of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K38/05A61P37/04
Inventor 罗秀琴刘贤英
Owner GUANGDONG SHUNFENG PHARMA
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