The invention relates to a method for synthesizing pyroglutamic calcium glutamate with shells serving as calcium sources. Processing steps comprise shell pretreatment, synthesis, crystallization and drying. The method includes immersing the shells with 0.05M hydrochloric acid, drying, smashing and processing the shells with elutriation to obtain calcium shell powder, compounding pyroglutamic acid with the shell powder (the calciumcontent of calcium carbonate is calculated by 95%) according to a molar ratio of 2: (1.0-1.2), adding distilled water 20 to 25 times of the weight of the shell powder, stirring and heating the mixture to 55 DEG C to 60 DEG C, keeping the temperature for 1.5 to 2.0 hours, and performing cooling and suction filtration; performing pressure reduction and concentration on the obtained filtrate to enable the volume to be1/10, adding 95% of edible alcohol until the ethanol saturation degree is 90%, performing stirring, standing and filtering; and performing suction filtration, and drying the obtain crystals in a drying oven of 90 DEG C to obtain the pyroglutamic calcium glutamate product. According to the method, the process is simple, the product water solubility is good, various shells can be utilized highly, and the product can serve as calcium supplement, dietary supplement for improving the brain health level and the like.