Compound emulsifiable paste for treating acne and preparation method thereof

A technology of compound cream and cream, which is applied to the delivery of non-active ingredient medical preparations, medical preparations containing active ingredients, ointment delivery, etc. It can solve the problem of affecting appearance, preparation stability, bioavailability of active ingredients of drugs, milk The composition of the paste base formulation is complex, the preparation time is shortened, etc., to achieve the effect of fine appearance, good feel and stability, and reduce equipment investment

Active Publication Date: 2013-04-03
乐泰药业有限公司
View PDF8 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The formula composition of traditional cream base is relatively complicated, generally composed of three components: water phase, oil phase and emulsifier, but most of the oil phase substances used are semi-solid or solid, and often need to be heated and emulsified to form semi-solid or liquid during preparation state, the process is long, and a cooling device is required to speed up the cooling speed to shorten the prep...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound emulsifiable paste for treating acne and preparation method thereof
  • Compound emulsifiable paste for treating acne and preparation method thereof
  • Compound emulsifiable paste for treating acne and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Take 0.8g of metronidazole and grind it through a 100-mesh sieve to make a fine powder, add 4g of glycerin to grind and mix, and prepare a well-mixed suspension for later use;

[0028] (2) Put 1 g of clindamycin hydrochloride in a beaker, dissolve it completely with 74.2 g of distilled water, add 5 g of penetration enhancer, add the suspension in step (1) after dissolving, stir and set aside; the penetration enhancer The agent is composed of azone and propylene glycol in a mass ratio of 1:4, that is, the amount of azone added is 1 g, and the amount of propylene glycol added is 4 g.

[0029] (3) Put 7g of white petrolatum, 1g of liquid paraffin, and 4g of simethicone into a beaker, add 3g of emulsifier and mix well, then slowly add to the suspension obtained in step (2) while stirring, and continue stirring 100g of compound cream for treating acne can be obtained in 3-5 minutes. Wherein the emulsifier is composed of polyacrylate 1.8g, polyisobutylene 0.5g and polyso...

Embodiment 2

[0031] (1) Take 0.8g of metronidazole and grind it through a 100-mesh sieve to make a fine powder, add 12g of glycerin to grind and mix, and prepare a well-mixed suspension for later use;

[0032] (2) Put 1 g of clindamycin hydrochloride in a beaker, dissolve it completely with 50.7 g of distilled water, add 6 g of penetration enhancer, add the suspension in step (1) after dissolving, stir and set aside; the penetration enhancer The agent is composed of azone and propylene glycol in a mass ratio of 1:4.

[0033] (3) Put 16g of white petrolatum, 3g of liquid paraffin, and 6g of simethicone into a beaker, add 4.5g of emulsifier and stir to mix evenly, then slowly add to the suspension obtained in step (2) while stirring, continue Stir for 3-5 minutes to get 100 g of compound cream for treating acne. Wherein the emulsifier consists of 2.5g of polyacrylate, 1g of polyisobutylene and 201g of polysorbate.

Embodiment 3

[0035] (1) Take 0.8g of metronidazole and grind it through a 100-mesh sieve to make a fine powder, add 10g of glycerin to grind and mix, and prepare a well-mixed suspension for later use;

[0036] (2) Put 1 g of clindamycin hydrochloride in a beaker, dissolve it completely with 60.5 g of distilled water, add 4 g of penetration enhancer, add the suspension in step (1) after dissolving, stir and set aside; The agent is composed of azone and propylene glycol in a mass ratio of 1:4.

[0037] (3) Put 12g of white petrolatum, 2g of liquid paraffin, and 5g of simethicone into a beaker, add 4.7g of emulsifier and stir to mix evenly, then slowly add to the suspension obtained in step (2) while stirring, continue Stir for 3-5 minutes to get 100 g of compound cream for treating acne. Wherein the emulsifier consists of polyacrylate 1.8g, polyisobutylene 0.5g, polysorbate 200.7g, sodium polyacrylate 0.7g, methyl cocoyl sodium taurate 0.5g, isohexadecane 0.3g and polysorbate Alcohol ester...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a compound emulsifiable paste for treating acne and a preparation method thereof. The compound emulsifiable paste comprises the following ingredients by weight percent: 1% of clindamycin hydrochloride, 0.8% of metronidazole, 7%-16% of albolene, 4%-12% of glycerol, 1%-3% of liquid paraffin, 4%-6% of simethicone, 3%-8% of emulsifying agent, 4%-6% of penetration enhancer and the balance of distilled water. The compound emulsifiable paste solves the difficulties that indissolvable drug can not be distributed uniformly, the drug with heat instability is decomposed and subjected to color change when being heated, the possibility of paste preparation in normal temperature can be realized, and the paste is ideal in appearance and is stable. Meanwhile, according to the compound emulsifiable paste, the permeability of corneum of the skin is improved, the effective dose of the drug achieving the wound part is ensured, the bioavailability of effective ingredients of the drug can be improved, the effective dose is reduced, and the toxicity and the skin irritation are low.

Description

technical field [0001] The invention relates to a compound cream and a preparation method thereof, in particular to a compound cream for treating acne and a preparation method thereof. Background technique [0002] Acne is one of the more common diseases in dermatology. Its main cause is the infection of Propionibacterium acnes, which mostly occurs in adolescents. Aesthetics and mental health. Acne preparations on the market are mostly liniments, and clindamycin and metronidazole liniment is one of the more commonly used drugs. Among them, clindamycin hydrochloride is a bacteriostatic antibiotic with high antibacterial activity. Metronidazole is an artificially synthesized nitroimidazole compound, which is widely used in anti-anaerobic infection and clinical treatment of rosacea and acne. Obvious side effects. However, traditional liniment has certain disadvantages, such as great skin irritation and short action time. Creams are less irritating than liniments and have a ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/7056A61K31/4164A61K9/06A61K47/32A61K47/34A61K47/22A61K47/10A61P17/10
Inventor 郎伟君
Owner 乐泰药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products