33 results about "Formulation stability" patented technology

The present disclosure relates to the production of cosmetic formulations with specified target properties. Disclosed are methods, apparatuses, systems for determining the stability of the formulation and specified target properties as well as generating formulation data for producing the formulation. Further disclosed are cosmetic products and cosmetic formulations produced based on the generated formulation control data.

The invention relates to the technical field of cosmetics, in particular to polyurethane oleogel, a preparation method of the polyurethane oleogel and application of the polyurethane oleogel in an anhydrous cosmetic formula. The polyurethane oleogel is prepared from a water-dispersible polyurethane film-forming agent, volatile grease and an organic modified layered silicate thickening agent through high-speed homogenization, and solves the technical bottleneck that water-dispersible polyurethane is difficult to be directly applied to an oil wax-based anhydrous formula; and the synergistic improvement of the anti-transfer property, the smearing smoothness and the formula stability of the anhydrous cosmetic formula can be considered.

A cosmetic composition having a pearlescent effect, according to one aspect, provides a pearlescent effect without a pearlescent pigment so as to improve aesthetics, can be used in various formulations such as low-viscosity skin formulations, can exhibit structural colors, and has excellent long-term formulation stability.

To provide a composition for skin cleansing that can prevent sedimentation and aggregation of powder components which impair formulation stability and foam characteristics, enable uniform dispersion of the powder components, and sustain the dispersion state.SOLUTION: A composition for skin cleansing containing a powder component, characterized by comprising Component A: an anionic surfactant (excluding Component D), Component B: an amphoteric surfactant, Component C: an acrylates copolymer, and Component D: an acyl isethionate salt.SELECTED DRAWING: None

The present invention relates to an oil-dispersed cosmetic composition having excellent suspension stability and, specifically, to an oil-dispersed cosmetic composition having excellent powder dispersibility, suspension stability, and formulation stability by optimally mixing a hydrogenated castor oil / sebacic acid copolymer as an oil thickener and silica dimethylsilylate as a dispersant.

A cosmetic composition for enhancing skin absorption of active ingredients and formulation stability is disclosed. The cosmetic composition contains three or more ingredients selected from the group consisting of bis-ethoxydiglycolcyclohexane 1,4-dicarboxylate, lysolecithin, citron seed oil, and glycereth-25 PCA isostearate. The cosmetic composition has effects of enhancing skin absorption of active ingredients and enhancing formulation stability.

The present disclosure relates to a makeup cosmetic composition having excellent lasting power and formulation stability. Specifically, the makeup cosmetic composition, according to the present disclosure, comprises alkyl glyceryl ether-modified silicone and thus exhibits remarkable lasting power of makeup while greatly improving formulation instability such as band generation and a decrease in viscosity resulting from containing the alkyl glyceryl ether-modified silicone, and improving a heavy feeling when used caused by high viscosity, thereby enabling excellent lasting power, formulation stability, and feeling of use.

According to the present invention, by using polysorbate and polyethylene glycol in combination, the solubility of a thiazolidinedione-based compound, particularly a thiazolidinedione-based compound having PPAR-γ agonistic activity, can be effectively improved. Therefore, the compound can be maintained in a homogeneous state in a composition without precipitation or crystal formation, and formulation stability suitable for local injection or local application can be ensured. In addition, the composition of the present invention can stably maintain the dissolved and dispersed state of the thiazolidinedione-based compound even at a low surfactant concentration, and thus can improve the reproducibility and application suitability of the formulation.

The invention discloses alkaline hydrolysis glue for double-color electroplating and a preparation method of the alkaline hydrolysis glue, the alkaline hydrolysis glue is uniform transparent liquid, and the alkaline hydrolysis glue comprises the following components in percentage by weight: 5.0-15.0 wt% of a film-forming agent, 2.0-8.0 wt% of an accelerant, 0.5-2.0 wt% of inorganic base, 0.1-1.0 wt% of a corrosion inhibitor, 80-90 wt% of a mixed solvent, 0.5-3.0 wt% of a cosolvent and 1-3 wt% of a dispersion stabilizer. The method has the advantages that the peptizing speed is increased, on-site preparation is not needed, the formula stability is high, the pungent smell is reduced, and the green production requirement is met.

The present disclosure relates to an injectable composition comprising tadalafil or a pharmaceutically acceptable salt thereof, a lipid, and a co-solvent. The injectable composition according to the present disclosure has the advantages of achieving a constant level of drug blood concentration over a long period of time, thereby reducing the number of drug administration, having excellent long-term safety due to absence of local tolerance and minimal side effects due to absence of initial rapid drug release, and providing high formulation stability.

This invention relates to the field of computer-aided process design technology, specifically to an intelligent optimization design method and system for greenhouse film formulations. The method includes the following steps: collecting signals of crystallinity, amorphous ratio, and crystalline inter-region spacing through film-making experiments and constructing a structure vector; completing crystallization discrimination based on transmittance targets and spacing thresholds; forming a formulation state sequence by combining raw material mass fractions and additive ratios; analyzing the crystallization evolution direction under multiple cooling and traction rate conditions; imposing constraints on parameter value ranges; and outputting the optimized greenhouse film formulation results. In this invention, through the joint characterization and discrimination of multi-dimensional signals of the crystal structure, formulation decisions rely on the microstructural state, combining the crystallization evolution direction and state transition relationship to form dynamic constraints on the raw material mass fraction and additive ratio, ensuring that the optimization results conform to processing conditions, reducing static parameter deviations, maintaining controllable performance and predictable trends under multiple operating conditions, and improving formulation stability and continuous adaptability.

The present invention provides an elastic fiber treatment agent for an elastic fiber which is excellent in formulation stability during long-term storage, has good retention of a winding shape during spinning, is excellent in unwinding property after winding, and imparts excellent antistatic property to an elastic fiber, and an elastic fiber to which the elastic fiber treatment agent is attached. As a means for solving the problem, the elastic fiber treatment agent of the present invention is characterized by containing dimethyl silicone (A), a carboxylic acid (B) having a branched alkyl group in a molecule, an alcohol (C), and a base component (D) composed of at least one selected from the group consisting of mineral oil and ester oil, wherein the containing ratio of dimethyl silicone (A), the carboxylic acid (B), the alcohol (C), and the base component (D) is such that, when the total is taken as 100 mass%, the carboxylic acid (B) is contained in a ratio of 0.1 to 27.0 mass%.

An object of the present invention is to provide an eye care composition which can be produced with a reduced risk of failure during production by not using a bilberry extract raw material, has good formulation stability, and can be reduced in dosage.SOLUTION: The above object can be achieved by an eye care composition comprising a Haematococcus alga extract, a marigold extract, a propolis extract and vitamin A as active ingredients, and an eye care composition comprising astaxanthin, lutein, zeaxanthin, a propolis extract and vitamin A as active ingredients.SELECTED DRAWING: None

The invention discloses a fat-burning oral liquid with a body-shaping function and a preparation process thereof, the oral liquid is a nano-emulsion, and is prepared from the following raw materials: a first active component (immature bitter orange extract), a second active component (L-carnitine), an auxiliary body-shaping component (such as globe artichoke extract and fennel fruit extract) and phospholipid. The key step of the preparation process is that an oil phase and a water phase containing active components are prepared into a stable nano-emulsion with the average particle size of 20-200 nanometers through high-pressure homogenization treatment. Compared with the prior art, the technical pain points that the core fat-burning component is low in bioavailability, poor in formula stability and obvious in side effect are solved, the stability, the absorptivity and the user experience of the product are remarkably improved through the synergistic composition and the innovative nano preparation process, and the composition has important application value.

The present invention relates to a cosmetic composition having an excellent exfoliating effect and, specifically, to a cosmetic composition which comprises, as two or more types of thickeners, a Sargassum fluitans / Natans extract and polyacrylate crosspolymer -6, and thus can contain a high content of acid in a formulation, thereby having an excellent sebum-removing and exfoliating effect and excellent formulation stability.

An oil-in-water cosmetic composition having no clouding phenomenon. The oil-in-water cosmetic composition according to the present application, as an organic / natural cosmetic composition not containing a polyethylene glycol-based surfactant, a silicone oil, and / or a synthetic polymer, can provide a cosmetic composition having no clouding phenomenon and excellent formulation stability by simultaneously containing a fatty alcohol and a lecithin-based surfactant.

The present invention relates to a cosmetic composition containing glutathione as an active ingredient and, more specifically, to a cosmetic composition which, through a combination of glutathione, fullerene, and polyacrylate crosspolymer, exhibits excellent deodorizing efficacy against glutathione and excellent formulation stability and skin feel.

The invention relates to the technical field of chemical synthesis processes of medicines, in particular to a preparation process of isocoline hydrochloride and application of the isocoline hydrochloride in eye drops, and solves the technical problems of various steps, low yield, high cost, serious environmental pollution and the like of an existing preparation process. A microwave synergistic palladium catalytic synthesis technology is adopted, 2-chloro-3-methylpyridine, phenylboronic acid and potassium carbonate are subjected to a microwave radiation reaction in an ethanol-water mixed solvent in the presence of a palladium catalyst, the power density is 0.15-0.25 W / mL, the reaction temperature is 120-140 DEG C, the reaction pressure is 0.2-0.5 MPa, the reaction time is 4.0-6.0 hours, and the isolorydine hydrochloride is obtained through cooling crystallization, filtering washing, drying and salifying treatment. According to the process, traditional 8-10-step synthesis is simplified into one-step reaction, the total yield is increased to 62.5% from 45%, the product purity reaches 99.2%, and the stability of the preparation is remarkably improved.

The present invention relates to a cosmetic composition comprising a lotus leaf extract and ferulic acid. The present invention can provide a cosmetic composition which can reduce concerns about precipitation by adding a lotus leaf extract to a composition containing ferulic acid to improve the solubility of ferulic acid and has excellent formulation stability. In addition, the composition exhibited superior moisturizing and anti-inflammatory effects compared to the use of lotus leaf extract or ferulic acid alone.

The present invention relates to an oil-in-water type liquid cosmetic composition having a high content of vitamin C and having improved formulation stability and feeling of use. The cosmetic composition according to the present invention comprises a high content of vitamin C, a derivative of vitamin C, an emulsifier, and a thickener, and is prepared by a method for achieving a stable formulation even under conditions of low viscosity and pH. Accordingly, it is possible to achieve a high content of vitamin C without precipitation, and simultaneously improve feeling of use and prevent oxidation in a cosmetic.

The present invention relates to a high-viscosity cosmetics composition having self-healing ability. The cosmetics composition of the present invention comprises a component having shear-thinning properties to maintain a cream phase while having high viscosity, thus being a good moisturizer and easy to spray, and having formulation stability.

The present invention relates to a high internal phase water-in-silicone (W / S) cosmetic composition having excellent stability, which comprises an oil and a non-crosslinked polyglycerin-based silicone emulsifier, wherein the cosmetic composition exhibits high formulation stability, an excellent water drop effect, and an excellent moisturizing effect while comprising a high content of pigments and a high content of an aqueous phase with a minimum amount of external phase, including the oil and the non-crosslinked polyglycerin-based silicone emulsifier.

The invention discloses a Rurugolil long-acting preparation composition as well as a preparation method and application thereof. The composition comprises an active medicine and at least one suspending aid. The Rurugolil long-acting preparation composition has an excellent slow-release effect, the administration interval can be prolonged to 7-90 days per time from 1 day per time, and the bioavailability, the compliance and the safety of a patient are remarkably improved. The pharmaceutical composition disclosed by the invention has the advantages of high preparation stability, simple prescription, controllable preparation process and capability of realizing industrial production amplification.

The present invention relates to a cosmetic composition comprising ferulic acid, a basic amino acid, and a pH adjusting agent, wherein decarboxylation reactions of the ferulic acid are suppressed so that the titer of the ferulic acid can be maintained even during long-term storage, and precipitation, discoloration, and deterioration of efficacy are prevented, thus providing a composition having excellent formulation stability.

Disclosed in the present invention are a long-acting formulation composition of Relugolix, a preparation method therefor, and use thereof. The composition comprises an active drug and at least one suspending agent. The long-acting formulation composition of Relugolix of the present invention has an excellent sustained-release effect, can prolong the administration interval from 1 day / time to 7 days to 90 days / time, and significantly improves the bioavailability, compliance, and safety of patients. The pharmaceutical composition of the present invention has the advantages of high formulation stability, simple prescription, controllable preparation process, and scale-up capability for industrial production.

The invention discloses an eperisone hydrochloride tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The eperisone hydrochloride tablet contains eperisone hydrochloride, a filler, a disintegrating agent, a compound stabilizer, hydrophobic fumed silica and a lubricant, the compound stabilizer is composed of L-malic acid, citrulline and L-cysteine hydrochloride in a specific ratio, and the hydrophobic fumed silica and the compound stabilizer are in a specific weight ratio. The filling agent, the disintegrating agent and the lubricating agent are all selected from adaptive components. The eperisone hydrochloride tablet disclosed by the invention is prepared by adopting a direct powder tabletting process, and film coating can be carried out as required through pretreatment of raw materials and auxiliary materials, step-by-step mixing and tabletting. The defects that eperisone hydrochloride is high in hygroscopicity and sensitive to temperature, humidity and light are overcome from the two aspects of inhibiting degradation of main drugs and reducing moisture absorption, the stability of the preparation and the processing property of powder are improved, the process is simple, convenient and environment-friendly, low-temperature light-proof storage is not needed, and the eperisone hydrochloride powder is suitable for industrial mass production.

The present disclosure relates to the production of cosmetic formulations with specified target properties. Disclosed are methods, apparatuses, systems for determining the stability of the formulation and specified target properties as well as generating formulation data for producing the formulation. Further disclosed are cosmetic products and cosmetic formulations produced based on the generated formulation control data.

The present invention relates to an ultraviolet-blocking cosmetic composition, wherein the cosmetic composition contains zinc oxide stabilized in a formulation through a zinc oxide dispersion, and thus exhibits excellent formulation stability and adhesion, low white turbidity, and superior ultraviolet-blocking performance. Specifically, the present invention relates to an ultraviolet-blocking cosmetic composition, wherein the cosmetic composition exhibits low white turbidity and exerts high ultraviolet-blocking ability by optimizing a dispersion containing ultra-high-content zinc oxide particles through mixing with an emulsifier and a dispersant.

According to an embodiment of the present application, a cosmetic composition for UV protection is provided. The cosmetic composition comprises: an aqueous phase comprising a first UV-blocking agent; and an oil phase comprising a second UV-blocking agent and an oil gelling agent, wherein the oil phase is encapsulated and dispersed in the aqueous phase, and the oil gelling agent may comprise polyamide-3. According to embodiments of the present application, due to the use of an oil gelling agent, the oil phase can be encapsulated and dispersed in the aqueous phase. By using polyamide-3 as the oil gelling agent, the cosmetic composition can provide a transparent formulation and exhibit excellent formulation stability, feeling of use, and UV protection efficacy.