55 results about "Formulation stability" patented technology

The present disclosure relates to the production of cosmetic formulations with specified target properties. Disclosed are methods, apparatuses, systems for determining the stability of the formulation and specified target properties as well as generating formulation data for producing the formulation. Further disclosed are cosmetic products and cosmetic formulations produced based on the generated formulation control data.

The invention relates to the technical field of cosmetics, in particular to polyurethane oleogel, a preparation method of the polyurethane oleogel and application of the polyurethane oleogel in an anhydrous cosmetic formula. The polyurethane oleogel is prepared from a water-dispersible polyurethane film-forming agent, volatile grease and an organic modified layered silicate thickening agent through high-speed homogenization, and solves the technical bottleneck that water-dispersible polyurethane is difficult to be directly applied to an oil wax-based anhydrous formula; and the synergistic improvement of the anti-transfer property, the smearing smoothness and the formula stability of the anhydrous cosmetic formula can be considered.

To provide a formulation with superior formulation stability for granular bath compositions containing magnesium sulfate heptahydrate, effectively suppressing the traditional issue of time-dependent solidification during storage.SOLUTION: A granular bath composition contains (A) magnesium sulfate heptahydrate and (B) water, the content of component (A) is 80 mass% or more, and the content of component (B) is 0.5-20 pts.mass relative to 100 pts.mass of the component (A). The granular bath composition is resistant to time-dependent solidification.SELECTED DRAWING: None

A cosmetic composition having a pearlescent effect, according to one aspect, provides a pearlescent effect without a pearlescent pigment so as to improve aesthetics, can be used in various formulations such as low-viscosity skin formulations, can exhibit structural colors, and has excellent long-term formulation stability.

To provide a composition for skin cleansing that can prevent sedimentation and aggregation of powder components which impair formulation stability and foam characteristics, enable uniform dispersion of the powder components, and sustain the dispersion state.SOLUTION: A composition for skin cleansing containing a powder component, characterized by comprising Component A: an anionic surfactant (excluding Component D), Component B: an amphoteric surfactant, Component C: an acrylates copolymer, and Component D: an acyl isethionate salt.SELECTED DRAWING: None

The present invention relates to an oil-dispersed cosmetic composition having excellent suspension stability and, specifically, to an oil-dispersed cosmetic composition having excellent powder dispersibility, suspension stability, and formulation stability by optimally mixing a hydrogenated castor oil / sebacic acid copolymer as an oil thickener and silica dimethylsilylate as a dispersant.

Disclosed are a pharmaceutical composition, an aprepitant injection, and an aprepitant freeze-dried powder injection. The pharmaceutical composition comprises aprepitant, a primary stabilizer, and a secondary stabilizer, wherein the primary stabilizer comprises sodium deoxycholate and the secondary stabilizer comprises povidone. The aprepitant injection can be administered by injecting. The formulation uses a largely reduced amount of excipients, and is less irritative to an injection site, less prone to cause a hypersensitive reaction, and thus safer when being used by a patient. The formulation has good stability and can be stored and transported at room temperature, largely reducing production, storage, and transportation costs.

A cosmetic composition for enhancing skin absorption of active ingredients and formulation stability is disclosed. The cosmetic composition contains three or more ingredients selected from the group consisting of bis-ethoxydiglycolcyclohexane 1,4-dicarboxylate, lysolecithin, citron seed oil, and glycereth-25 PCA isostearate. The cosmetic composition has effects of enhancing skin absorption of active ingredients and enhancing formulation stability.

The present disclosure relates to a makeup cosmetic composition having excellent lasting power and formulation stability. Specifically, the makeup cosmetic composition, according to the present disclosure, comprises alkyl glyceryl ether-modified silicone and thus exhibits remarkable lasting power of makeup while greatly improving formulation instability such as band generation and a decrease in viscosity resulting from containing the alkyl glyceryl ether-modified silicone, and improving a heavy feeling when used caused by high viscosity, thereby enabling excellent lasting power, formulation stability, and feeling of use.

According to the present invention, by using polysorbate and polyethylene glycol in combination, the solubility of a thiazolidinedione-based compound, particularly a thiazolidinedione-based compound having PPAR-γ agonistic activity, can be effectively improved. Therefore, the compound can be maintained in a homogeneous state in a composition without precipitation or crystal formation, and formulation stability suitable for local injection or local application can be ensured. In addition, the composition of the present invention can stably maintain the dissolved and dispersed state of the thiazolidinedione-based compound even at a low surfactant concentration, and thus can improve the reproducibility and application suitability of the formulation.

The invention discloses alkaline hydrolysis glue for double-color electroplating and a preparation method of the alkaline hydrolysis glue, the alkaline hydrolysis glue is uniform transparent liquid, and the alkaline hydrolysis glue comprises the following components in percentage by weight: 5.0-15.0 wt% of a film-forming agent, 2.0-8.0 wt% of an accelerant, 0.5-2.0 wt% of inorganic base, 0.1-1.0 wt% of a corrosion inhibitor, 80-90 wt% of a mixed solvent, 0.5-3.0 wt% of a cosolvent and 1-3 wt% of a dispersion stabilizer. The method has the advantages that the peptizing speed is increased, on-site preparation is not needed, the formula stability is high, the pungent smell is reduced, and the green production requirement is met.

The present disclosure relates to an injectable composition comprising tadalafil or a pharmaceutically acceptable salt thereof, a lipid, and a co-solvent. The injectable composition according to the present disclosure has the advantages of achieving a constant level of drug blood concentration over a long period of time, thereby reducing the number of drug administration, having excellent long-term safety due to absence of local tolerance and minimal side effects due to absence of initial rapid drug release, and providing high formulation stability.

The present invention relates to a high concentration heparan N-sulfatase (HNS) pharmaceutical composition with enhanced stability for CNS delivery and a pharmaceutical formulation comprising the same. The pharmaceutical composition and the pharmaceutical formulation comprising the same according to the present invention have excellent formulation stability, such as reduction of turbidity and significant improvement of purity, which can be used in enzyme replacement therapy (ERT) for the treatment of type III mucopolysaccharide storage disease.

This invention relates to the field of computer-aided process design technology, specifically to an intelligent optimization design method and system for greenhouse film formulations. The method includes the following steps: collecting signals of crystallinity, amorphous ratio, and crystalline inter-region spacing through film-making experiments and constructing a structure vector; completing crystallization discrimination based on transmittance targets and spacing thresholds; forming a formulation state sequence by combining raw material mass fractions and additive ratios; analyzing the crystallization evolution direction under multiple cooling and traction rate conditions; imposing constraints on parameter value ranges; and outputting the optimized greenhouse film formulation results. In this invention, through the joint characterization and discrimination of multi-dimensional signals of the crystal structure, formulation decisions rely on the microstructural state, combining the crystallization evolution direction and state transition relationship to form dynamic constraints on the raw material mass fraction and additive ratio, ensuring that the optimization results conform to processing conditions, reducing static parameter deviations, maintaining controllable performance and predictable trends under multiple operating conditions, and improving formulation stability and continuous adaptability.

The present invention provides an elastic fiber treatment agent for an elastic fiber which is excellent in formulation stability during long-term storage, has good retention of a winding shape during spinning, is excellent in unwinding property after winding, and imparts excellent antistatic property to an elastic fiber, and an elastic fiber to which the elastic fiber treatment agent is attached. As a means for solving the problem, the elastic fiber treatment agent of the present invention is characterized by containing dimethyl silicone (A), a carboxylic acid (B) having a branched alkyl group in a molecule, an alcohol (C), and a base component (D) composed of at least one selected from the group consisting of mineral oil and ester oil, wherein the containing ratio of dimethyl silicone (A), the carboxylic acid (B), the alcohol (C), and the base component (D) is such that, when the total is taken as 100 mass%, the carboxylic acid (B) is contained in a ratio of 0.1 to 27.0 mass%.

[Problem] An objective of the present invention is to provide a water-in-oil emulsion cosmetic that does not tend to form color streaks (streaks caused by pigments becoming non-uniform), that has excellent formulation stability and that has smooth properties in use. [Solution] The water-in-oil emulsion cosmetic of the present invention is characterized by comprising (A) an amino acid-treated pigment, (B) an organically modified clay mineral, and (C) an oil gelling agent other than component (B).

The present invention relates to the use of a composition in the preparation of a cosmetic material having improved formulation stability, and in particular, to the use of a composition comprising Ferulic acid; and one or more selected from the group consisting of Beta-sitosterol and Linoleic acid in the preparation of a cosmetic material having improved formulation stability. In addition, the composition of the present invention improves the low formulation stability of Ferulic acid, and confirms that when combined with one or more selected from the group consisting of Beta-sitosterol and Linoleic acid, the effects of antioxidation, melanin reduction, collagen synthesis promotion, and hyaluronic acid synthesis promotion all produce synergistic effects compared to Ferulic acid alone.

An object of the present invention is to provide an eye care composition which can be produced with a reduced risk of failure during production by not using a bilberry extract raw material, has good formulation stability, and can be reduced in dosage.SOLUTION: The above object can be achieved by an eye care composition comprising a Haematococcus alga extract, a marigold extract, a propolis extract and vitamin A as active ingredients, and an eye care composition comprising astaxanthin, lutein, zeaxanthin, a propolis extract and vitamin A as active ingredients.SELECTED DRAWING: None

The invention discloses a fat-burning oral liquid with a body-shaping function and a preparation process thereof, the oral liquid is a nano-emulsion, and is prepared from the following raw materials: a first active component (immature bitter orange extract), a second active component (L-carnitine), an auxiliary body-shaping component (such as globe artichoke extract and fennel fruit extract) and phospholipid. The key step of the preparation process is that an oil phase and a water phase containing active components are prepared into a stable nano-emulsion with the average particle size of 20-200 nanometers through high-pressure homogenization treatment. Compared with the prior art, the technical pain points that the core fat-burning component is low in bioavailability, poor in formula stability and obvious in side effect are solved, the stability, the absorptivity and the user experience of the product are remarkably improved through the synergistic composition and the innovative nano preparation process, and the composition has important application value.

The present invention relates to a cosmetic composition having an excellent exfoliating effect and, specifically, to a cosmetic composition which comprises, as two or more types of thickeners, a Sargassum fluitans / Natans extract and polyacrylate crosspolymer -6, and thus can contain a high content of acid in a formulation, thereby having an excellent sebum-removing and exfoliating effect and excellent formulation stability.

An oil-in-water cosmetic composition having no clouding phenomenon. The oil-in-water cosmetic composition according to the present application, as an organic / natural cosmetic composition not containing a polyethylene glycol-based surfactant, a silicone oil, and / or a synthetic polymer, can provide a cosmetic composition having no clouding phenomenon and excellent formulation stability by simultaneously containing a fatty alcohol and a lecithin-based surfactant.

The present invention relates to a cosmetic composition containing glutathione as an active ingredient and, more specifically, to a cosmetic composition which, through a combination of glutathione, fullerene, and polyacrylate crosspolymer, exhibits excellent deodorizing efficacy against glutathione and excellent formulation stability and skin feel.

The invention relates to the technical field of chemical synthesis processes of medicines, in particular to a preparation process of isocoline hydrochloride and application of the isocoline hydrochloride in eye drops, and solves the technical problems of various steps, low yield, high cost, serious environmental pollution and the like of an existing preparation process. A microwave synergistic palladium catalytic synthesis technology is adopted, 2-chloro-3-methylpyridine, phenylboronic acid and potassium carbonate are subjected to a microwave radiation reaction in an ethanol-water mixed solvent in the presence of a palladium catalyst, the power density is 0.15-0.25 W / mL, the reaction temperature is 120-140 DEG C, the reaction pressure is 0.2-0.5 MPa, the reaction time is 4.0-6.0 hours, and the isolorydine hydrochloride is obtained through cooling crystallization, filtering washing, drying and salifying treatment. According to the process, traditional 8-10-step synthesis is simplified into one-step reaction, the total yield is increased to 62.5% from 45%, the product purity reaches 99.2%, and the stability of the preparation is remarkably improved.

The present invention relates to a cosmetic composition comprising a lotus leaf extract and ferulic acid. The present invention can provide a cosmetic composition which can reduce concerns about precipitation by adding a lotus leaf extract to a composition containing ferulic acid to improve the solubility of ferulic acid and has excellent formulation stability. In addition, the composition exhibited superior moisturizing and anti-inflammatory effects compared to the use of lotus leaf extract or ferulic acid alone.

The present invention relates to an oil-in-water type liquid cosmetic composition having a high content of vitamin C and having improved formulation stability and feeling of use. The cosmetic composition according to the present invention comprises a high content of vitamin C, a derivative of vitamin C, an emulsifier, and a thickener, and is prepared by a method for achieving a stable formulation even under conditions of low viscosity and pH. Accordingly, it is possible to achieve a high content of vitamin C without precipitation, and simultaneously improve feeling of use and prevent oxidation in a cosmetic.

The present invention relates to a high-viscosity cosmetics composition having self-healing ability. The cosmetics composition of the present invention comprises a component having shear-thinning properties to maintain a cream phase while having high viscosity, thus being a good moisturizer and easy to spray, and having formulation stability.

Provided are an oral solid tablet comprising (S)-7-[4-(1-acryloylpiperidine)]-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and preparation method therefor. The oral solid tablet has good drug release characteristics, features easy administration, quick and high-efficient release, no particular requirements on equipment, and a simple formulation preparation process, can ensure formulation stability and facilitate transportation and storage, and is suitable for large-scale production.

The purpose of the present invention is to provide a sepetaprost-containing eye drop having exceptional formulation stability.　The present invention relates to an eye drop containing sepetaprost, the eye drop being accommodated in an ethylene-oxide-gas-sterilized eye drop container.

The present invention relates to a high internal phase water-in-silicone (W / S) cosmetic composition having excellent stability, which comprises an oil and a non-crosslinked polyglycerin-based silicone emulsifier, wherein the cosmetic composition exhibits high formulation stability, an excellent water drop effect, and an excellent moisturizing effect while comprising a high content of pigments and a high content of an aqueous phase with a minimum amount of external phase, including the oil and the non-crosslinked polyglycerin-based silicone emulsifier.