The invention relates to a
nifedipine controlled-release tablet composition, comprising the following components in percentage by weight: 4.0-35.0% of
nifedipine, 5.0-20.0% of polyoxyethylene, 5.0-30.0% of high-
viscosity hydrophilic matrix material, 5.0-20.0% of a hydrophobic
retarder, 20.0-60.0% of a filling agent, 0-10.0% of an
adhesive solution, and 0.5-1.0% of a
lubricant. A preparation method of the composition comprises the following steps: micronizing raw materials under a dark condition until the
fineness ensures the
powder to pass through a 200-mesh
sieve, and screening an auxiliary material through a
sieve with 80-100 meshes; adding the medicinal raw materials into the
adhesive solution, and stirring uniformly for later use; and weighing a formula amount of polyoxyethylene, hydroxypropyl methylcellulose, the
retarder namely
ethyl cellulose and the filling agent, mixing uniformly, adding the prepared
adhesive solution to prepare a soft material, and performing
granulation,
drying, straightening, addition of the
lubricant, total blending, tabletting and
package to obtain the composition. The
nifedipine controlled-release tablet composition has the advantages that the preparation process is simple and easy, the production cost is low, and the
production cycle is short.