42results about How to "Clear release curve" patented technology

The invention discloses temperature-sensitive gel containing ropivacaine and used for long-acting injection and a preparation method of the temperature-sensitive gel. The gel comprises a main drug ropivacaine, ropivacaine hydrochloride or ropivacaine mesylate, a PLGA (poly (lactic-co-glycolic acid)) -PEG (polyethylene glycol)-PLGA copolymer as well as water, normal saline or pH regulation solution for injection, wherein the mole ratio of lactide to glycolide is (2-3): 1, and the PEG molecular weight of the PLGA-PEG-PLGA copolymer is 1,000. The preparation method comprises the following steps: the copolymer is sufficiently swelled in a solvent firstly, then the main drug is added, and sterilization is performed through a filter membrane. The temperature-sensitive gel facilitates drug delivery and can gel rapidly at human body temperature so as to play a slow release role, smaller than or equal to 35%-45% of the drug is released in vitro after 12 h, larger than or equal to 65%-75% of the drug is released after 48 h, larger than or equal to 80% of the drug is released after 72 h, and the design requirement for postoperative continuous analgesia for 48 h through single injection of a local anesthesia drug is met. Pharmacodynamics study shows that a temperature-sensitive gel group containing ropivacaine can prolong the efficacy maintaining time remarkably and continuously play 48 h analgesic effect.

The invention relates to a nifedipine controlled-release tablet composition, comprising the following components in percentage by weight: 4.0-35.0% of nifedipine, 5.0-20.0% of polyoxyethylene, 5.0-30.0% of high-viscosity hydrophilic matrix material, 5.0-20.0% of a hydrophobic retarder, 20.0-60.0% of a filling agent, 0-10.0% of an adhesive solution, and 0.5-1.0% of a lubricant. A preparation method of the composition comprises the following steps: micronizing raw materials under a dark condition until the fineness ensures the powder to pass through a 200-mesh sieve, and screening an auxiliary material through a sieve with 80-100 meshes; adding the medicinal raw materials into the adhesive solution, and stirring uniformly for later use; and weighing a formula amount of polyoxyethylene, hydroxypropyl methylcellulose, the retarder namely ethyl cellulose and the filling agent, mixing uniformly, adding the prepared adhesive solution to prepare a soft material, and performing granulation, drying, straightening, addition of the lubricant, total blending, tabletting and package to obtain the composition. The nifedipine controlled-release tablet composition has the advantages that the preparation process is simple and easy, the production cost is low, and the production cycle is short.

The invention provides a beta-carotene micro-pill prepared from beta-carotene and medicinal adjuvant, characterized in that the medicinal adjuvant comprises an excipient and a bonding agent; the content of the beta-carotene in the beta-carotene micro-pill is 1-10 weight percent, the excipient 70-95 weight percent and the bonding agent 1-5 weight percent. The beta-carotene micro-pill of the invention has the advantages of high dissolution rate, high bioavailability, easy preparation method and convenient and easy operation.

The invention provides a sea buckthorn extract pellet preparation composed of sea buckthorn and medical supplementary materials. The sea buckthorn extract pellet preparation is characterized in that the medical supplementary materials are excipients and binders; and in the pellet preparation, the content of sea buckthorn extract 2-75 percent by weight, the content of excipients is 20-97 percent by weight, and the content of binders is 1-5 percent by weight. The pellet preparation has high dissolution rate and high bioavailability, and the preparation method is simple, convenient and easy for operation.

The invention discloses a pellet formulation of donkey-hide gelatin which is prepared by donkey-hide gelatin and pharmaceutical excipients, wherein the pharmaceutical excipients are excipient and adhesive. In the pellet formulation, the weight percentage of the donkey-hide gelatin is 20-80 %, the weight percentage of the excipient is 20-80%, and the weight percentage of the adhesive is 1-5%. The pellet formulation can be made into sustained release formulation or enteric-coated formulation according to the requirements. The inventive pellet formulation has high dissolution rate and bioavailability, easy and convenient preparation method, and easy operation.

The invention relates to a sustained release pharmaceutical formulation, and in particular relates to a diclofenac sodium sustained release tablet and a preparation method thereof. The diclofenac sodium sustained release tablet is prepared from diclofenac sodium, lactose, calcium sulfate, ethylcellulose, acrylic resin, hydroxypropyl methylcellulose, magnesium stearate and 95% ethanol in certain proportions. The diclofenac sodium sustained release tablet is simple in preparation process, low in cost, good in formulation stability and excellent in release rate.

The invention discloses a pellet formulation of sea cucumber peptide which is prepared by sea cucumber peptide and pharmaceutical excipients, wherein the pharmaceutical excipients are excipient and adhesive. In the pellet formulation, the weight percentage of the sea cucumber peptide is 2-85%, the weight percentage of the excipient is 20-80%, and the weight percentage of the adhesive is 1-5%. The inventive pellet preparation has high dissolution rate and bioavailability, easy and convenient preparation method, and easy operation.

The invention provides a preparation of a vitamin E micropill which is made of vitamin E and medical accessories and is characterized in that the medical accessories comprise excipient and bond. The preparation of the micropill is made of the following components by the weight percentage: 1-85 percent of vitamin E, 15-99 percent of excipient and 1-5 percent of bond. The preparation of the micropill has the advantages of high stripping rate and high bioavailability, and the preparation method is simple and convenient and can be operated easily.

The invention relates to the field of medical technology and discloses a long-acting preparation of lactic-glycolic acid copolymer (PLGA) for the recombination of endostatin of vein and the application to preparing a drug for treating tumor. The invention uses four methods of implanting a pump in vivo, implanting a microsphere in vivo, a W/O/W solvent volatilization method and a W/O/O solvent volatilization method to prepare the long-acting preparation. The sustained-release time of the long-acting preparation prepared is 7 to 28 days in accordance with the needs.

The invention provides a ganoderan polysaccharide pellet preparation, which is prepared from ganoderan polysaccharides and pharmaceutical adjuvants. The ganoderan polysaccharide pellet preparation is characterized in that: the pharmaceutical adjuvants are an excipient and a binding agent, wherein the pellet preparation comprises the following components in percentage by weight: 10 to 20 percent of ganoderan polysaccharides, 3 to 89 percent of excipient and 1 to 7 percent of bonding agent. The pellet preparation can be prepared into a slow-release or enteric-coated preparation as required. The ganoderan polysaccharide pellet preparation of the invention has high dissolving rate and high bioavailability. The method of the invention is simple, convenient and easy to operate.

The invention provides a lutein pellet, which is prepared from lutein and a pharmaceutic adjuvant. The lutein pellet is characterized in that the pharmaceutic adjuvant is an excipient and an adhesive, wherein the pellet preparation contains 5-20% of lutein, 70-85% of excipient and 1-5% of adhesive. The lutein pellet disclosed by the invention is high in dissolution rate, and high in bioavailability, and the preparation method is simple, convenient and easy to operate.

The invention provides a collagen pellet preparation, which is prepared from a collagen and a pharmaceutic adjuvant. The collagen pellet preparation is characterized in that the pharmaceutic adjuvant is an excipient and an adhesive; the weight percentage of the collagen in the pellet preparation is between 10 and 90 percent; the weight percentage of the excipient is between 20 and 80 percent; and the weight percentage of the adhesive is between 1 and 5 percent. The pellet preparation of the invention has the advantages of high dissolution rate, high bioavailability, simple and convenient preparation method, and easy operation.

The invention provides a poria extract pellet preparation, which is prepared from a poria extract and pharmaceutical auxiliary materials and is characterized in that the auxiliary materials comprise an excipient and an adhesive; and in the pellet preparation, the weight percentage of the poria extract is 5-80%, the weight percentage of the excipient is 19-85% and the percentage of the adhesive is 1-10%. The pellet preparation can be prepared into a sustained-release or intestine-soluble preparation as required. Pharmacological experiments show that the pellet provided by the invention has good actions of enhancing immune function, protecting liver and the like.

The invention discloses a compound lozenge controlling childe tooth decay, and belongs to the technical field of medicines. The lozenge comprises medicinal compositions and auxiliary material compositions. The medicinal compositions comprise, in parts by weight, 1-3 parts of lysyl oxidase, 1.5-2.5 parts of D-galactose, 5-8 parts of nanometer diatomite, 0.2-0.6 part of calcium dihydrogen phosphate, 0.11-0.13 part of chromium picolinate, 0.08-0.1 part of tretinoin, 0.02-0.03 part of tiamcinolone acetonide. The auxiliary material compositions comprise, in parts by weight, 70-100 parts of a medicine carrier, 0.12-0.25 part of a solvent, 0.01-0.03 part of an aseptic, 0.14-0.26 part of compound vitamin, and 2-5 parts of a corrigent. The lozenge contains multiple effective compositions, is reasonable in matching ratio, is capable of resisting bacteria, diminishing inflammation, removing dental plaque and harmful bacteria, preventing and treating decayed teeth and preventing carious teeth, does not cause anaphylactic reaction, and enhances oral cavity health-care effect.

The invention provides an agaric extract pellet preparation which is prepared from an agaric extract and pharmaceutic adjuvants and is characterized in that the pharmaceutic adjuvants comprise an excipient and a binding agent; and the pellet preparation comprises 15-70wt% of the agaric extract, 25-84wt% of the excipient and 1-5wt% of the binding agent. The pellet preparation can be prepared into a sustained-release preparation or an enteric preparation according to requirements. Pharmacology experiments show that the pellet provided by the invention has the effects of improving the immunity, resisting cancers and the like.

The invention provides a preparation of a folium ginkgo extract micropill which is made of a folium ginkgo extract and medical accessories and is characterized in that the medical accessories comprise excipient and bond. The preparation of the folium ginkgo extract micropill is made of the following components by the weight percentage of 0.5-85 percent of folium ginkgo extract, 15-99.5 percent of excipient and 1-5 percent of bond. The preparation of the micropill has the advantages of high stripping rate and high bioavailability, and the preparation method is simple and convenient and can be operated easily.

The invention provides a medlar extract pellet preparation, which is prepared with medlar extracts and pharmaceutical excipients. The medlar extract pellet preparation is characterized in that the pharmaceutical excipients adopt excipients and adhesives, the weight percentage of the medlar extracts in the pellet preparation is 10-60 percent, the weight percentage of the excipients is 35-89 percent, and the weight percentage of the adhesives is 1-5 percent. The pellet preparation can be made into sustained-release or enteric-coated preparations in accordance with requirements. Pharmacological experiments show that the pellet has good functions of resisting against aging and improving the immunity and the like.