Nifedipine sustained release tablet and preparation method thereof

A nifedipine and gentle technology, which is applied in the field of pharmaceutical and chemical engineering, can solve the problems of dissolution rate difference, insufficient release rate, and drug release that cannot meet clinical needs, and achieve good stability of preparations, reduced number of administrations, and good release curves Effect

Inactive Publication Date: 2018-01-12
ANHUI YONSENT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yet in the nifedipine sustained-release tablet of prior art, still exist some problems, for example in " different manufacturers nifedipine sustained-release tablet in vitro release test " (" Journal of Tianjin Medical University ", 17 (4), 2011) It is pointed out that there are significant differences in the dissolution rate of different manufacturers, and most manufacturers still have insufficient indicators such as release rate, so that the release of drugs sometimes cannot meet clinical needs.

Method used

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  • Nifedipine sustained release tablet and preparation method thereof
  • Nifedipine sustained release tablet and preparation method thereof
  • Nifedipine sustained release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A nifedipine sustained-release tablet, consisting of the following raw materials in parts by weight:

[0031]

[0032] The method for making described nifedipine slow-release tablet, described method may further comprise the steps:

[0033] Step 1 ingredients: weighing various raw materials;

[0034] Step 2 Granulation: dry mix the prepared raw and auxiliary materials in a mixing granulator for 3 minutes, add a binder to make a soft material, and granulate with a 24-mesh sieve;

[0035] Step 3 drying: place the prepared wet granules in a high-efficiency boiling dryer and dry them at a constant temperature for 20-minutes;

[0036] Step four granulation and total mixing: the dried granules are sieved through a 24-mesh sieve for granulation, add talcum powder and mix in a three-dimensional motion mixer for 15 minutes;

[0037] Step 5 compressing tablet, coating;

[0038] Step 6 Aluminum-plastic packaging, outer packaging, and storage.

[0039] Preferably, in the thi...

Embodiment 2

[0043] A nifedipine sustained-release tablet, consisting of the following raw materials in parts by weight:

[0044]

[0045] The method for making described nifedipine slow-release tablet, described method may further comprise the steps:

[0046] Step 1 ingredients: weighing various raw materials;

[0047] Step 2 Granulation: dry mix the prepared raw and auxiliary materials in a mixing granulator for 3 minutes, add a binder to make a soft material, and granulate with a 24-mesh sieve;

[0048] Step 3 Drying: Dry the prepared wet granules in a high-efficiency boiling dryer at a constant temperature for 30 minutes;

[0049] Step four granulation and total mixing: the dried granules are sieved through a 24-mesh sieve for granulation, add talcum powder and mix in a three-dimensional motion mixer for 15 minutes;

[0050] Step 5 compressing tablet, coating;

[0051] Step 6 Aluminum-plastic packaging, outer packaging, and storage.

[0052] Preferably, in the third step, the mo...

Embodiment 3

[0056] A nifedipine sustained-release tablet, consisting of the following raw materials in parts by weight:

[0057]

[0058] The method for making described nifedipine slow-release tablet, described method may further comprise the steps:

[0059] Step 1 ingredients: weighing various raw materials;

[0060] Step 2 Granulation: dry mix the prepared raw and auxiliary materials in a mixing granulator for 3 minutes, add a binder to make a soft material, and granulate with a 24-mesh sieve;

[0061] Step 3 Drying: Dry the prepared wet granules in a high-efficiency boiling dryer at a constant temperature for 25 minutes;

[0062] Step four granulation and total mixing: the dried granules are sieved through a 24-mesh sieve for granulation, add talcum powder and mix in a three-dimensional motion mixer for 15 minutes;

[0063] Step 5 compressing tablet, coating;

[0064] Step 6 Aluminum-plastic packaging, outer packaging, and storage.

[0065] Preferably, in the third step, the mo...

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Abstract

The invention relates to a nifedipine sustained release tablet and a preparation method of the nifedipine sustained release tablet. The nifedipine sustained release tablet is prepared from the following raw materials in parts by weight: 5-15 parts of nifedipine, 15-25 parts of microcrystalline cellulose, 40-60 parts of lactose, 3-8 parts of hydroxypropyl methyl cellulose K4M, 0.1-5 parts of sodiumdodecyl sulfate, 0.3-1 part of 95% alcohol, 0.5-10 parts of magnesium stearate, 8-12 parts of Opadry II, and 100-120 parts of water. For the nifedipine sustained release tablet and the preparation method provided by the invention, nitrobenzene and a high polymer material are mixed to prepare a hydrophilic gel matrix tablet, so that the purpose of slow release is achieved. Compared with a common tablet, the sustained release tablet provided by the invention has the advantages of long acting duration, mild action, slow release, and few and slight adverse reactions.

Description

technical field [0001] The invention relates to the field of medicine and chemical industry, in particular to a nifedipine sustained-release tablet and a preparation method thereof. Background technique [0002] Nifedipine Sustained-release Tablets, Nifedipine is a dihydropyridine calcium antagonist, which can selectively inhibit the transmembrane transport of calcium ions into cardiomyocytes and smooth muscle cells, and inhibit the release of calcium ions from the intracellular pool without changing plasma Calcium ion concentration is currently recognized as one of the safe and effective first-line antihypertensive drugs. [0003] However, since the late 1980s, it has been proved by medical practice that common preparations of nifedipine reflexively cause increased heart rate and activate the sympathetic nervous system, which is not conducive to the control of myocardial ischemia and heart failure; medication requirements. As the third generation of pharmaceutical prepara...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/28A61K31/4422A61K47/38A61K47/26A61K47/20A61P9/12
Inventor 程玉柱符俊峰马晶晶
Owner ANHUI YONSENT PHARMA
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