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Lutein micropills and preparation thereof

A technology of lutein and pellets, applied in the field of medicine and food, can solve the problems of low bioavailability, long disintegration time, irritation of gastric mucosa, etc. Effect

Inactive Publication Date: 2008-07-09
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, products about lutein are well received by consumers. These products are basically ordinary tablets and capsules, but the above-mentioned dosage forms have a long disintegration time; The mucous membrane is irritating to a certain extent; the disadvantages such as low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take the following ingredients for the recipe

[0034] Lutein

1g (based on pure product)

Crystalline Cellulose

95g

Hydroxypropylmethylcellulose

4g

[0035] Prepare pellet formulations as follows:

[0036] (1) Take the lutein of the above-mentioned formula amount and add the crystal cellulose, pulverize it to the micronized level with a ball mill, and mix well;

[0037] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0038] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0040] Take the following ingredients for the recipe

[0041] Lutein

5g (based on pure product)

starch

90g

Polyvinylpyrrolidone

5g

[0042] Prepare pellet formulations as follows:

[0043] (1) Take the lutein of the above-mentioned formula amount and add it to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0044] (2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0045] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0047] Take the following ingredients for the recipe

[0048] Lutein

8g (based on pure product)

sucrose

54

starch

34g

Polyvinylpyrrolidone

4g

[0049] Prepare pellet formulations as follows:

[0050] (1) Take the lutein of the above-mentioned formula amount, add sucrose and starch, pulverize to micronized level with a ball mill, and mix well;

[0051] (2) Polyvinylpyrrolidone is dissolved in an appropriate amount of water;

[0052] (3) The centrifugal-fluidized pelletizing method is used to make pellets.

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Abstract

The present invention provides a xanthin pellet preparation which is made from the xanthin and medical auxiliary materials and is characterized in that the medical auxiliary materials are excipient and bond. In the pellet preparation, the weight percentages of the materials are: 1 percent to 10 percent of the xanthin, 75 percent to 95 percent of the excipient and 1 percent to 5 percent of the bond. The pellet preparation of the present invention has high leaching rate and high biological utilization degree, and the preparation method is simple and convenient and is easy for operation.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of lutein and a preparation method thereof. Background technique: [0002] Lutein and zeaxanthin are the main components of plant pigments such as vegetables, fruits, and flowers, and are also the main pigments that constitute the macular area of ​​the human eye. Human eyes contain a high amount of lutein, which cannot be produced by the human body and must be supplemented by intake of lutein. Without this element, the eyes will be blind. Foreign studies have shown that: lutein can prevent eye light damage, prevent visual atrophy and blindness caused by lutein deficiency, as well as cardiovascular sclerosis, coronary heart disease and tumor diseases caused by body aging. It is the main component that cannot be lost in the retina and macula of the eye; it prevents the physiological structure and function of the eye from changing; it is a powerful antioxid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/047A61K9/20A61K47/32A61K47/38A61P27/02A61P9/10A61P35/00
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV
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