Ganoderan polysaccharide pellet and preparation method thereof

A technology of polysaccharide pellets and Ganoderma lucidum polysaccharides, which is applied in food preparation, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of low bioavailability, long disintegration time, gastric mucosa irritation, etc., and achieve biological The effect of high utilization, good effectiveness, and low dosage of excipients

Inactive Publication Date: 2010-05-12
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many forms of Ganoderma lucidum polysaccharide products, which are well recognized by consumers. These products are basically ordinary tablets and capsules, but the above dosage forms have a long disintegration time and disintegrate at a certain point in the body. , has a certain degree of irritation to the gastric mucosa, and has disadvantages such as low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take the following ingredients for the recipe

[0033] Ganoderma lucidum polysaccharide

30g

microcrystalline cellulose

66g

Hydroxypropylmethylcellulose

4g

[0034] Prepare pellet formulations as follows:

[0035] (1) Add the ganoderma lucidum polysaccharide of the above-mentioned formula amount to microcrystalline cellulose, pulverize it to a micronized level with a ball mill, and mix well;

[0036] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0037] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0039] Take the following ingredients for the recipe

[0040] Ganoderma lucidum polysaccharide

50g

sucrose

48g

Polyvinylpyrrolidone

2g

[0041] Prepare pellet formulations as follows:

[0042] (1) Take the Ganoderma lucidum polysaccharide of the above-mentioned formula amount and add sucrose, pulverize it to a micronized level with a ball mill, and mix well;

[0043] (2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0044] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0046] Take the following ingredients for the recipe

[0047] Ganoderma lucidum polysaccharide

73g

starch

21g

Polyvinylpyrrolidone

6g

[0048] Prepare pellet formulations as follows:

[0049] (1) Take the Ganoderma lucidum polysaccharide of the above formula amount and add it to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0050] (2) Polyvinylpyrrolidone is dissolved in an appropriate amount of water;

[0051] (3) The pellets are made by the centrifugal-fluidized pelletizing method.

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Abstract

The invention provides a ganoderan polysaccharide pellet preparation, which is prepared from ganoderan polysaccharides and pharmaceutical adjuvants. The ganoderan polysaccharide pellet preparation is characterized in that: the pharmaceutical adjuvants are an excipient and a binding agent, wherein the pellet preparation comprises the following components in percentage by weight: 10 to 20 percent of ganoderan polysaccharides, 3 to 89 percent of excipient and 1 to 7 percent of bonding agent. The pellet preparation can be prepared into a slow-release or enteric-coated preparation as required. The ganoderan polysaccharide pellet preparation of the invention has high dissolving rate and high bioavailability. The method of the invention is simple, convenient and easy to operate.

Description

Technical field: [0001] The invention relates to a micropill of natural food extract and a preparation method thereof, in particular to a micropill made of ganoderma lucidum polysaccharide and a preparation method thereof. Background technique: [0002] Ganoderma lucidum, commonly known as "Ganoderma lucidum grass", is a unique and precious medicinal material in the treasure house of traditional Chinese medicine. In the history of our country, Ganoderma lucidum is regarded as the elite of plants and trees, endowed with the aura of heaven and earth, so it is also called "immortal grass". The "Shen Nong's Materia Medica" in the Eastern Han Dynasty and the famous "Compendium of Materia Medica" in the Ming Dynasty all proved that Ganoderma lucidum has the effect of preventing and curing diseases and prolonging life. [0003] Ganoderma lucidum polysaccharides are important physiologically active ingredients contained in Ganoderma lucidum. Ancient and modern pharmacology and clini...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/074A61K9/16A61P3/06A61P3/10A61P35/00A61P37/04A61P39/06A23L1/30A23L33/125
Inventor 赵粉荣
Owner JF PHARMALAND TECH DEV
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