73results about How to "Good reproducibility of curative effect" patented technology

The invention discloses a diabecron and glipizide -containing slow-release agent and the method for preparing the same. The glipizide micro-pill takes blank micro-pill as carrier, and combines glipizide and other medical findings with it. The diabecron-containing slow-release micro-pill comprises diabetosan pill, slow-release coating membrane material or other medical findings. The method for preparing diabecron-containing slow-release micro-pill takes extrusion rolling method or blank micro-pill loading method. The product is characterized by safety, high efficient, low toxicity and convenient usage. It can be used to treat non-insulin-dependent diabetes mellitus.

The invention provides a folic acid pellet preparation composed of folic acid and medical supplementary materials. The folic acid pellet preparation is characterized in that the medical supplementary materials are excipients and binders; and in the pellet preparation, the content of folic acid is 0.02-20 percent by weight, the content of excipients is 75-99.98 percent by weight, and the content of binders is 1-5 percent by weight. The pellet preparation has high dissolution rate and high bioavailability, and the preparation method is simple, convenient and easy for operation.

The invention provides a tea polyphenols micro-pill that is prepared from tea polyphenols and pharmaceutical adjuvant, which is characterized in that the pharmaceutical adjuvant is an excipient and a bonding agent. The tea polyphenol micro-pill comprises (by weight percentage) that: tea polyphenols 20-80 percent, the excipient 15-79 percent and the bonding agent 1-5 percent. The tea polyphenols micro-pill can be made into sustained-release preparation or enteric-coated preparation. The pharmacological experiment indicates that the tea polyphenols micro-pill of the invention has good effect on radioresistance, anti-aging, etc.

The invention discloses a pellet type pantoprazole sodium enteric capsule and a preparation method thereof. The pellet type pantoprazole sodium enteric capsule is a sustained-release preparation composed of a capsule shell and uniformly mixed pantoprazole sodium pellets held in the capsule shell; the pantoprazole sodium pellet from inside to outside in turn comprises a blank pellet core, a main drug layer, an isolation layer and an enteric layer, wherein the weight of the main drug layer is 14-55% of that of the blank pellet core, the weight of the isolation layer is 9-10% of that of the total weight of the blank pellet core and the main drug layer, the weight of the enteric layer is 28-32% of that of the total weight of the blank pellet core, the main drug layer and the isolation layer; 40-60% of that of the pantoprazole sodium pellet is coated with a pigmented layer on the outside of the enteric layer; the weight of the pigmented layer is 0.5-1% of that of the total weight of the blank pellet core, the main drug layer, the isolation layer and the enteric layer; the diameter of the blank pellet core is 0.8-1.0 mm; the granularity of the pantoprazole sodium pellet is 14-20 mesh; each capsule contains 20-40 mg of the pantoprazole sodium. The pellet type pantoprazole sodium enteric capsule has the advantages of acidproof, rapid release and stable.

The invention provides sanchi extract pellets, which are prepared from a sanchi extract and medicinal accessories, and are characterized in that: the medicinal accessories comprise an excipient and a bonding agent; the sanchi extract accounts for 10 to 90 percent of the weight of the pellets; the excipient accounts for 4 to 89 percent of the weight of the pellets; and the bonding agent accounts for 1 to 6 percent of the weight of the pellets. The pellets can be made into a sustained-release or enteric-coated preparation. The sanchi extract pellets of the invention have high dissolution rate and high bioavailability. The method of the invention is simple, convenient and easy to operate.

The invention provides a zinc gluconate pellet preparation, which is prepared from zinc gluconate and pharmaceutic adjuvant, and is characterized in that: the pharmaceutic adjuvant is an excipient and an adhesive, wherein in the pellet preparation, the weight percent of the zinc gluconate is 10 to 80 percent, the weight percent of the excipient is 12 to 89 percent and the weight percent of the adhesive is 1 to 8 percent. The pellet preparation can be prepared into a slow release preparation or an enteric-coated preparation. The zinc gluconate pellet preparation has high dissolution rate, and high bioavailability; and the method is simple, convenient, and easy to operate.

The invention provides a desertliving cistanche herb extract pellet preparation composed of desertliving cistanche herb extract and medical supplementary materials. The desertliving cistanche herb extract pellet preparation is characterized in that the medical supplementary materials are excipients and binders; and in the pellet preparation, the content of desertliving cistanche herb extract 1-80 percent by weight, the content of excipients is 20-99 percent by weight, and the content of binders is 1-5 percent by weight. The pellet preparation has high dissolution rate and high bioavailability, and the preparation method is simple, convenient and easy for operation.

The invention provides a preparation of propolis micropill which is made of propolis and medical accessories and is characterized in that the medical accessories comprise excipient and bond. The preparation of the micropill is made of the following components by the weight percentage: 5-80 percent of propilis, 20-95 percent of excipient and 1-5 percent of bond. The preparation of the micropill has the advantages of high stripping rate and high bioavailability, and the preparation method is simple and convenient and can be operated easily.

The invention provides a dangshen extract pellet preparation, which is prepared from a dangshen extract and pharmaceutical adjuvants, and is characterized in that: an excipient and a bonding agent are taken as the pharmaceutical adjuvants; and the pellet preparation comprises the following components in percentage by weight: 30-70 percent of a dangshen extract, 20-65 percent of an excipient and 1-10 percent of a bonding agent. The pellet preparation can be prepared into a slow-release or enteric preparation as required. As proved by a pharmacological experiment, the pellet disclosed by the invention has the effects of tonifying middle-jiao and qi, invigorating the spleen, promoting the production of body fluid, and the like.

The invention discloses a mini-pill type nicergoline capsule and a preparation method thereof. The mini-pill type nicergoline capsule is a sustained-release preparation and is prepared from a capsule shell and a nicergoline mini-pill accommodated in the capsule shell, wherein the nicergoline mini-pill sequentially comprises an empty pill core, a main drug layer and a pigmented layer from inside to outside; the main drug layer accounts for 15-60 percent of the empty pill core, and the pigmented layer accounts for 0.5-1 percent of the total weight of the empty pill core and the main drug layer. The mini-pill type nicergoline capsule has the advantages of small stimulation to intestines and stomach, high utilization rate, high stability, less toxic or side effects and capability of fully releasing effective components in time.

The invention provides a chondroitin sulfate pellet preparation, which is prepared from chondroitin sulfate and pharmaceutic adjuvant. The pellet preparation is characterized in that the pharmaceutic adjuvant is excipient and bonding agent, wherein the pellet preparation comprises the following components in percentage by weight: 10 to 90 percent of the chondroitin sulfate, 3 to 89 percent of the excipient, and 1 to 7 percent of the bonding agent. The pellet preparation can be prepared into a slow-release preparation or an enteric-coated preparation as requested. The chondroitin sulfate pellet preparation has high dissolution rate and high bioavailability, and the method is simple and convenient and is easy to operate.

The invention provides an astragalus polyose pellet preparation composed of astragalus polyose and medical supplementary materials. The astragalus polyose pellet preparation is characterized in that the medical supplementary materials are excipients and binders; and in the pellet preparation, the content of astragalus polyose 0.5-70 percent by weight, the content of excipients is 30-99.5 percent by weight, and the content of binders is 1-5 percent by weight. The pellet preparation has high dissolution rate and high bioavailability, and the preparation method is simple, convenient and easy for operation.

The invention discloses a pellet type omeprazole enteric capsule and a preparation method thereof. The pellet type omeprazole enteric capsule is a sustained-release preparation, and is composed of a capsule shell and evenly mixed omeprazole pellets received in the capsule shell; each omeprazole pellet is composed of a blank pill core, a main drug layer, an isolation layer and an enteric layer in order from inside to outside, wherein the weight of the main drug layer accounts for 15-60% of that of the blank pill core, the weight of the isolation layer accounts for 10% of the total weight of the blank pill core and the main drug layer, the weight of the enteric layer accounts for 28-32% of the total weight of the blank pill core, the main drug layer and the isolation layer; besides, the enteric layers of 40-60% of omeprazole pellets are further coated with pigment layers; the weight of the pigment layer accounts for 0.5-1% of the total weight of the blank pill core, the main drug layer, the isolation layer and the enteric layer; the diameters of the blank pill cores are 0.8-1.0mm; the granularity of the omeprazole pellets is 14-20 meshes; each capsule contains 15-30mg of omeprazole. The pellet type omeprazole enteric capsule has the advantages of good acid resistance, sufficient active ingredient release without delay, good stability and the like.

The invention provides a magnolia bark extract pellet preparation which is prepared from a magnolia bark extract and pharmaceutic adjuvants and is characterized in that the pharmaceutic adjuvants comprise an excipient and a binding agent; and the pellet preparation comprises 10-60wt% of the magnolia bark extract, 35-89wt% of the excipient and 1-5wt% of the binding agent. The pellet preparation can be prepared into a sustained-release preparation or an enteric preparation according to requirements. Pharmacology experiments show that the pellet provided by the invention has the effects of sterilizing, tranquilizing and allaying excitement and the like.

The invention provides a beta-carotene micro-pill prepared from beta-carotene and medicinal adjuvant, characterized in that the medicinal adjuvant comprises an excipient and a bonding agent; the content of the beta-carotene in the beta-carotene micro-pill is 1-10 weight percent, the excipient 70-95 weight percent and the bonding agent 1-5 weight percent. The beta-carotene micro-pill of the invention has the advantages of high dissolution rate, high bioavailability, easy preparation method and convenient and easy operation.

The invention provides a red ginseng extract pellet preparation, which is prepared from a red ginseng extract and pharmaceutical adjuvants, and is characterized in that: an excipient and a bonding agent are taken as the pharmaceutical adjuvants; and the pellet preparation comprises the following components in percentage by weight: 2-80 percent of a red ginseng extract, 15-97 percent of an excipient and 1-5 percent of a bonding agent. The pellet preparation can be prepared into a slow-release or enteric preparation as required. As proved by a pharmacological experiment, the pellet has the effects of reinforcing vital energy, restoring pulses, preventing exhaustion, tonifying qi and controlling blood.

The invention provides a sea buckthorn extract pellet preparation composed of sea buckthorn and medical supplementary materials. The sea buckthorn extract pellet preparation is characterized in that the medical supplementary materials are excipients and binders; and in the pellet preparation, the content of sea buckthorn extract 2-75 percent by weight, the content of excipients is 20-97 percent by weight, and the content of binders is 1-5 percent by weight. The pellet preparation has high dissolution rate and high bioavailability, and the preparation method is simple, convenient and easy for operation.

The invention discloses a pellet formulation of donkey-hide gelatin which is prepared by donkey-hide gelatin and pharmaceutical excipients, wherein the pharmaceutical excipients are excipient and adhesive. In the pellet formulation, the weight percentage of the donkey-hide gelatin is 20-80 %, the weight percentage of the excipient is 20-80%, and the weight percentage of the adhesive is 1-5%. The pellet formulation can be made into sustained release formulation or enteric-coated formulation according to the requirements. The inventive pellet formulation has high dissolution rate and bioavailability, easy and convenient preparation method, and easy operation.

The present invention provides a soybean isoflavone pellet preparation which is made from the soybean isoflavone and medical auxiliary materials and is characterized in that the medical auxiliary materials are excipient and bond. In the pellet preparation, the weight percentages of the materials are that: 1 percent to 50 percent of the soybean isoflavone, 55 percent to 98 percent of the excipient and 1 percent to 5 percent of the bond. The pellet preparation can be made into a slow-release or intestinal juice soluble preparation according to the requirement. The pellet preparation of the present invention has high leaching rate and high biological utilization degree, and the preparation method is simple and convenient and is easy for operating.

The invention discloses a pellet formulation of pearl powder which is prepared by pearl powder and pharmaceutical excipients, wherein the pharmaceutical excipients are excipient and adhesive. In the pellet formulation, the weight percentage of the pearl powder is 5-80%, the weight percentage of the excipient is 20-95%, and the weight percentage of the adhesive is 1-5%. The inventive pellet formulation has high dissolution rate and bioavailability, easy and convenient preparation method, and easy operation.

The invention provides a levocarnitine micro-pill which is prepared from levocarnitine and pharmaceutic adjuvant, characterized in that the pharmaceutic adjuvant is an excipient and a bonding agent; the content of the levocarnitine in the levocarnitine micro-pill is 10 to 90 weight percent; the excipient 20-80 weight percent and the bonding agent 1-5 weight percent. The levocarnitine micro-pill of the invention has the advantages of high dissolution rate, high bioavailability, easy preparation method and convenient and easy operation.

The invention discloses a pellet formulation of sea cucumber peptide which is prepared by sea cucumber peptide and pharmaceutical excipients, wherein the pharmaceutical excipients are excipient and adhesive. In the pellet formulation, the weight percentage of the sea cucumber peptide is 2-85%, the weight percentage of the excipient is 20-80%, and the weight percentage of the adhesive is 1-5%. The inventive pellet preparation has high dissolution rate and bioavailability, easy and convenient preparation method, and easy operation.

The invention provides a compound hyaluronic acid pellet preparation. The compound hyaluronic acid pellet preparation is prepared from hyaluronic acid, VC and pharmaceutical accessories and is characterized in that the pharmaceutical accessories include an excipient and an adhesive; and the compound hyaluronic acid pellet preparation contains 5-20% by weight of hyaluronic acid, 1-5% by weight of VC, 70-85% by weight of the excipient and 1-5% by weight of the adhesive. The compound hyaluronic acid pellet preparation disclosed by the invention has high dissolution rate and bioavailability; and a preparation method is simple, convenient and easy to operate.

The invention provides a tremella extract pellet preparation which is prepared from a tremella extract and pharmaceutic adjuvants and is characterized in that the pharmaceutic adjuvants comprise an excipient and a binding agent; and the pellet preparation comprises 10-65wt% of the tremella extract, 30-89wt% of the excipient and 1-5wt% of the binding agent. The pellet preparation can be prepared into a sustained-release preparation or an enteric preparation according to requirements. Pharmacology experiments show that the pellet provided by the invention has the effects of strengthening sperms, tonifying the kidney, strengthening the lung, promoting the production of the body fluid, relieving a cough, reducing pathogenic fire, moisturizing the intestine, reinforcing the stomach, tonifying Qi and blood, toughening a body and the like.

The invention provides a preparation of a vitamin E micropill which is made of vitamin E and medical accessories and is characterized in that the medical accessories comprise excipient and bond. The preparation of the micropill is made of the following components by the weight percentage: 1-85 percent of vitamin E, 15-99 percent of excipient and 1-5 percent of bond. The preparation of the micropill has the advantages of high stripping rate and high bioavailability, and the preparation method is simple and convenient and can be operated easily.

The invention discloses a mushroom extract sustained-release pellet. The mushroom extract sustained-release pellet is prepared from a mushroom extract and pharmaceutical adjuvant, and is coated with a sustained-release film; the sustained-release film comprises a polymer material, a pore forming agent and an adhesive resisting agent; the mushroom extract is 22-39% of the content of the pellet preparation in percentage by weight; the sustained-release film is 2-9% of the content of the pellet preparation in percentage by weight; the pharmaceutical adjuvant comprises an excipient and an adhesive; the excipient is 52-75% of the content of the pellet preparation in percentage by weight; the adhesive is 1-6% of the content of the pellet preparation in percentage by weight. The sustained-release pellet prepared by a preparation method of the mushroom extract sustained-release pellet can regulate immunity; the area of the sustained-release pellet on the surface of an absorption organ is increased, so that the bioavailability is improved, and the local irritation is little or removed.

The invention relates to novel tea polyphenol spherical particles, and provides a tea polyphenol micro-pellet preparation, which is prepared from tea polyphenol and pharmaceutical auxiliary materials, and is characterized in that the pharmaceutical auxiliary materials comprise an excipient and a binder, wherein the tea polyphenol content in the micro-pellet preparation is 5-30 wt%, the excipient content in the micro-pellet preparation is 75-90 wt%, and the binder content in the micro-pellet preparation is 1-5 wt%. According to the present invention, the micro-pellet preparation has characteristics of high bioavailability and high dissolution rate, and the preparation method is simple, convenient and easy to operate.

The invention provides a ganoderan polysaccharide pellet preparation, which is prepared from ganoderan polysaccharides and pharmaceutical adjuvants. The ganoderan polysaccharide pellet preparation is characterized in that: the pharmaceutical adjuvants are an excipient and a binding agent, wherein the pellet preparation comprises the following components in percentage by weight: 10 to 20 percent of ganoderan polysaccharides, 3 to 89 percent of excipient and 1 to 7 percent of bonding agent. The pellet preparation can be prepared into a slow-release or enteric-coated preparation as required. The ganoderan polysaccharide pellet preparation of the invention has high dissolving rate and high bioavailability. The method of the invention is simple, convenient and easy to operate.