Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology for tea polyphenols and tea polyphenol pellets, which is applied in the field of medicine and food to achieve the effects of high bioavailability and rapid onset of action
Inactive Publication Date: 2016-05-11
JF PHARMALAND TECH DEV
View PDF0 Cites 2 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0002] At present, products related to tea polyphenols are widely recognized by consumers, and they are basically ordinary tablets and capsules, but the above dosage forms have a long disintegration time Disintegrate at a certain point in the body, which has certain irritation to the gastric mucosa; low bioavailability and other disadvantages
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0028] Take the following ingredients for the recipe
[0029] Tea polyphenols 10g
[0030] Microcrystalline cellulose 82g
[0031] Hydroxypropyl Methyl Cellulose 4g
[0032] Prepare pellet formulations as follows:
[0033] (1) Take the tea polyphenols in the amount of the above formula, add microcrystalline cellulose, grind to micronized level with a ball mill, and mix well;
[0034] (2) Dissolve hydroxypropyl methylcellulose in 75% ethanol solution;
[0035] (3) Micro-pills are made by extrusion-spheronization into pellets.
Embodiment 2
[0037] Take the following ingredients for the recipe
[0038] Tea polyphenols 15g
[0039] Starch 85g
[0040] Polyvinylpyrrolidone 5g
[0041] Prepare pellet formulations as follows:
[0042] (1) Take the tea polyphenols in the amount of the above formula, add starch, grind to micronized level with a ball mill, and mix well;
[0043] (2) Dissolve the adhesive polyvinylpyrrolidone in water;
[0044] (3) Micro-pills are made by pan-pill method.
Embodiment 3
[0046] Take the following ingredients for the recipe
[0047] Tea polyphenols 8g
[0048] Sucrose 49g
[0049] Starch 34g
[0050] Polyvinylpyrrolidone 4g
[0051] Prepare pellet formulations as follows:
[0052] (1) Take the tea polyphenols in the amount of the above formula, add sucrose and starch, grind to micronized level with a ball mill, and mix well;
[0053] (2) Dissolve polyvinylpyrrolidone in an appropriate amount of water;
[0054] (3) Using the centrifugal-fluidized pelleting method to make pellets.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention relates to novel tea polyphenol spherical particles, and provides a tea polyphenol micro-pellet preparation, which is prepared from tea polyphenol and pharmaceutical auxiliary materials, and is characterized in that the pharmaceutical auxiliary materials comprise an excipient and a binder, wherein the tea polyphenol content in the micro-pellet preparation is 5-30 wt%, the excipient content in the micro-pellet preparation is 75-90 wt%, and the binder content in the micro-pellet preparation is 1-5 wt%. According to the present invention, the micro-pellet preparation has characteristics of high bioavailability and high dissolution rate, and the preparation method is simple, convenient and easy to operate.
Description
Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a tea polyphenol pellet and a preparation method thereof. Background technique: [0002] At present, the products about tea polyphenols are well received by consumers, and they are basically ordinary tablets and capsules. Certain irritation; low bioavailability and other disadvantages. Based on the above problems, we introduced the rapid development of micropill technology in the field of medicine to the field of food, and made this product into a compound micropill product with controllable release in the body and high bioavailability, so as to better meet the needs of the general public. consumer needs. [0003] Pharmaceutical excipients such as excipients, binders, porogens, disintegrants, and plasticizers are generally added during the preparation of pellet preparations ["Design and Development of Sustained and Controlled Release Preparations", Yan Yaodong et a...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more