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Novel tea polyphenol spherical particles

A technology for tea polyphenols and tea polyphenol pellets, which is applied in the field of medicine and food to achieve the effects of high bioavailability and rapid onset of action

Inactive Publication Date: 2016-05-11
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, products related to tea polyphenols are widely recognized by consumers, and they are basically ordinary tablets and capsules, but the above dosage forms have a long disintegration time Disintegrate at a certain point in the body, which has certain irritation to the gastric mucosa; low bioavailability and other disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take the following ingredients for the recipe

[0029] Tea polyphenols 10g

[0030] Microcrystalline cellulose 82g

[0031] Hydroxypropyl Methyl Cellulose 4g

[0032] Prepare pellet formulations as follows:

[0033] (1) Take the tea polyphenols in the amount of the above formula, add microcrystalline cellulose, grind to micronized level with a ball mill, and mix well;

[0034] (2) Dissolve hydroxypropyl methylcellulose in 75% ethanol solution;

[0035] (3) Micro-pills are made by extrusion-spheronization into pellets.

Embodiment 2

[0037] Take the following ingredients for the recipe

[0038] Tea polyphenols 15g

[0039] Starch 85g

[0040] Polyvinylpyrrolidone 5g

[0041] Prepare pellet formulations as follows:

[0042] (1) Take the tea polyphenols in the amount of the above formula, add starch, grind to micronized level with a ball mill, and mix well;

[0043] (2) Dissolve the adhesive polyvinylpyrrolidone in water;

[0044] (3) Micro-pills are made by pan-pill method.

Embodiment 3

[0046] Take the following ingredients for the recipe

[0047] Tea polyphenols 8g

[0048] Sucrose 49g

[0049] Starch 34g

[0050] Polyvinylpyrrolidone 4g

[0051] Prepare pellet formulations as follows:

[0052] (1) Take the tea polyphenols in the amount of the above formula, add sucrose and starch, grind to micronized level with a ball mill, and mix well;

[0053] (2) Dissolve polyvinylpyrrolidone in an appropriate amount of water;

[0054] (3) Using the centrifugal-fluidized pelleting method to make pellets.

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PUM

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Abstract

The invention relates to novel tea polyphenol spherical particles, and provides a tea polyphenol micro-pellet preparation, which is prepared from tea polyphenol and pharmaceutical auxiliary materials, and is characterized in that the pharmaceutical auxiliary materials comprise an excipient and a binder, wherein the tea polyphenol content in the micro-pellet preparation is 5-30 wt%, the excipient content in the micro-pellet preparation is 75-90 wt%, and the binder content in the micro-pellet preparation is 1-5 wt%. According to the present invention, the micro-pellet preparation has characteristics of high bioavailability and high dissolution rate, and the preparation method is simple, convenient and easy to operate.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a tea polyphenol pellet and a preparation method thereof. Background technique: [0002] At present, the products about tea polyphenols are well received by consumers, and they are basically ordinary tablets and capsules. Certain irritation; low bioavailability and other disadvantages. Based on the above problems, we introduced the rapid development of micropill technology in the field of medicine to the field of food, and made this product into a compound micropill product with controllable release in the body and high bioavailability, so as to better meet the needs of the general public. consumer needs. [0003] Pharmaceutical excipients such as excipients, binders, porogens, disintegrants, and plasticizers are generally added during the preparation of pellet preparations ["Design and Development of Sustained and Controlled Release Preparations", Yan Yaodong et a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K31/353A61K9/20A61K9/22A61K9/28A23L1/29
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV
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