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Astragalus polyose pellet and preparation method thereof

The technology of astragalus polysaccharide and pellets is applied in the field of medicine and food, which can solve the problems of low bioavailability, long disintegration time, irritation of gastric mucosa, etc., and achieves the effects of high bioavailability, good effectiveness and reducing the number of times of administration.

Inactive Publication Date: 2009-06-03
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These products are basically ordinary tablets and capsules, but the above-mentioned dosage forms have disadvantages such as long disintegration time; disintegration at a certain point in the body, which is irritating to the gastric mucosa; and low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take the following ingredients for the recipe

[0033] Astragalus polysaccharide 5g starch 91.5g Hydroxypropylmethylcellulose 3.5g

[0034] Prepare pellet formulations as follows:

[0035] (1) Add the astragalus polysaccharide of the above-mentioned formula amount to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0036] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0037] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0039] Take the following ingredients for the recipe

[0040] Astragalus polysaccharide 20g starch 75g Polyvinylpyrrolidone 5g

[0041] Prepare pellet formulations as follows:

[0042] (1) Take the astragalus polysaccharide of the above formula amount and add it to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0043] (2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0044] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0046] Take the following ingredients for the recipe

[0047] Astragalus polysaccharide 50g Crystalline Cellulose 46.5g Hydroxypropylmethylcellulose 3.5g

[0048]Prepare pellet formulations as follows:

[0049] (1) Add the astragalus polysaccharide of the above-mentioned formula amount to the crystal cellulose, pulverize it to a micronized level with a ball mill, and mix well;

[0050] (2) hydroxypropyl methylcellulose is dissolved in an appropriate amount of 70% ethanol;

[0051] (3) The centrifugal-fluidized pelletizing method is used to make pellets.

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Abstract

The invention provides an astragalus polyose pellet preparation composed of astragalus polyose and medical supplementary materials. The astragalus polyose pellet preparation is characterized in that the medical supplementary materials are excipients and binders; and in the pellet preparation, the content of astragalus polyose 0.5-70 percent by weight, the content of excipients is 30-99.5 percent by weight, and the content of binders is 1-5 percent by weight. The pellet preparation has high dissolution rate and high bioavailability, and the preparation method is simple, convenient and easy for operation.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of astragalus polysaccharide and a preparation method thereof. Background technique: [0002] Astragalus is the dried root of the leguminous plant Astragalus mongolica or Astragalus membranaceus. Astragalus has a long history and is widely used in clinical practice. It is one of the most commonly used traditional Chinese medicines in the past dynasties. In recent years, with the in-depth research on polysaccharides, it has been found that polysaccharides have various biological activities and functions. Astragalus polysaccharide, one of the main active components of Astragalus, has also attracted much attention because of its strong activity in enhancing the body's immunity, lowering blood sugar, and anti-aging. [0003] At present, products related to astragalus polysaccharides are favored by consumers. These products are basically ordinary tablets an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/20A61K31/715A61P3/10A61P37/02A61K36/481
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV
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