106 results about "Astragalus verus" patented technology

The invention provides a microecological preparation with an immunological enhancement function and application of the microecological preparation in antibiotic-free breeding of livestock and poultry, and relates to the technical field of agricultural biology. The microecological preparation with the immunological enhancement function comprises a probiotic component, a prebiotics component and an immunological enhancement component, and the probiotic component, the prebiotics component and the immunological enhancement component are respectively composed of lactic acid bacteria, bacillus, clostridium butyricum, fructo-oligosaccharide, yeast beta-glucan, astragalus polysaccharide and chitosan oligosaccharide. Wherein the lactic acid bacteria accounts for 30%-40%, the bacillus accounts for 20%-30%, the clostridium butyricum accounts for 10%-20%, the fructo-oligosaccharide accounts for 5%-10%, the yeast beta-glucan accounts for 3%-8%, the astragalus polysaccharide accounts for 2%-5%, and the chitosan The probiotics can enhance immunity and regulate intestinal tracts at the same time, the effect is improved by 40% or above compared with common probiotics, animals suffer less illness and grow fast, flora can resist high temperature and gastric acid through a special protection technology, the loss of viable bacteria is less than 5% after the probiotics are stored for 3 months, and the probiotics are stable by two times compared with conventional products.

This application relates to the technical field of astragalus polysaccharides, and specifically relates to a method for extracting astragalus polysaccharides. A method for extracting astragalus polysaccharides includes the following steps: primary water extraction, secondary water extraction, vacuum concentration, primary alcohol precipitation, secondary alcohol precipitation, and purification. Among them, in the primary water extraction: soak astragalus with a weak alkaline solution, then heat to boiling and carry out extraction, and filter to separate the primary precipitate and the primary extract. By using a weak alkaline solution in the primary water extraction step, this application destroys cell walls, increases the solubility of polysaccharides, and promotes the release of polysaccharides, significantly improving the extraction rate of astragalus polysaccharides.

The invention discloses an efficient extraction method of large-molecular-weight astragalus polysaccharide, which belongs to the technical field of plant extraction, and comprises the following steps: cleaning astragalus, filtering, and crushing; the preparation method comprises the following steps: mixing a beta-1, 3-glucanase aqueous solution and trehalose ethylene diamine, and stirring for 10-30 minutes to obtain an enzyme protection system; soaking the radix astragali powder in a citric acid solution, adding an enzyme protection system, applying a bipolar pulsed electric field, and reacting at 40-60 DEG C for 30-40 minutes; adjusting the concentration of the ethanol to 40-50%, standing, centrifuging and collecting crude astragalus polysaccharide; purifying, decolorizing, concentrating, freeze-drying and crushing the crude astragalus polysaccharide to obtain refined astragalus polysaccharide; the mass ratio of the trehalose ethylene diamine to the beta-1, 3-glucanase is (15: 1) to (30: 1). The enzyme protection system maintains the activity of the enzyme, the enzyme and the pulsed electric field act synergistically, the extraction time is shortened, and the extraction rate is increased while the astragalus polysaccharide with large molecular weight is obtained.

The invention discloses an IV-type collagen detection kit and a preparation method thereof, and relates to the technical field of in vitro diagnos.The kit comprises a reagent R1 and a reagent R2, and the volume ratio of the reagent R1 to the reagent R2 is 3: 1; through an elaborately designed reagent formula, especially the accurate proportion of all components in the reagent R1, such as ammonium chloride, sodium azide and Brij-35, the detection sensitivity and accuracy are improved, the stability and repeatability of the kit are also ensured, and particularly, the natural plant extract astragalus polysaccharide and the protease K inhibitor are introduced into the reagent R1 as key components, so that the detection sensitivity and accuracy are improved, and the detection sensitivity and repeatability are improved. According to the present invention, the unique preparation method and the activity promotion effect on the IV-type collagen hydrolase significantly enhance the biological activity of the kit, such that the detection result is reliable, and the two latex particles coated with the paired mouse monoclonal antibodies adopted in the reagent R2 have high specificity and affinity, such that the kit can be used for the detection of the IV-type collagen hydrolase. And the detection accuracy and sensitivity are further improved.

The invention belongs to the technical field of animal immunopotentiators, and particularly relates to an oil-in-water type veterinary adjuvant and a preparation method thereof. The oil-in-water type veterinary adjuvant comprises white oil, span 80, Tween 80, PEG400, astragalus polysaccharide and a phosphate buffer solution, the astragalus polysaccharide cooperates with a surfactant to activate a TLR4 / NF-kappa B pathway, Th1 / Th2 / Th17 three-way immune response is achieved, the serum IgG and mucous membrane sIgA antibody level is remarkably improved, and the problems that a traditional O / W adjuvant is high in layering rate (smaller than 5%), and the stability of the traditional O / W adjuvant is poor are solved through compound optimization of the HLB value (HLB = 11.5-12.0) of the HLB value of span 80 and Tween 80. And storage at 4 DEG C for 90 days) and poor freeze-thaw stability are solved.

The invention discloses an agricultural synergist containing astragalus polysaccharide and application of the agricultural synergist, and belongs to the technical field of killing agents for biopesticides. The synergist comprises astragalus polysaccharide, a polysorbate / lecithin compound emulsifier, a carboxymethyl chitosan / siloxane penetrant and a modified accelerant synthesized by palladium catalysis. Polysaccharide is structurally modified through a blue light LED induced tetra (triphenylphosphine) palladium catalytic reaction, and the epidermal penetration efficiency of the biopesticide on tetranychus urticae is improved by 3.2 times in combination with the synergistic permeation effect of a siloxane derivative. The mite killing rate of the suspending agent prepared according to a preferable formula reaches 92.5% within 24 hours, and the lasting period is prolonged to 14 days. The system overcomes the defects of slow effectiveness and poor stability of the traditional biopesticide, by means of a targeted combination mechanism of natural components, the environment friendliness is kept while the original pesticide dosage is reduced by 50%, and the system is particularly suitable for the pest control requirement of organic agriculture.

The invention belongs to the field of microbial fermentation, and particularly discloses a method for fermenting astragalus membranaceus by lactobacillus plantarum. The method comprises the following steps: S1, crushing and sterilizing astragalus membranaceus; s2, inoculating lactobacillus plantarum LP-301; and S3, carrying out fermentation culture. After astragalus membranaceus is fermented by the lactobacillus plantarum LP-301, the contents of substances such as flavonoids, quinones and terpenes in a fermentation product are remarkably increased, so that the lactobacillus plantarum LP-301 can be used for preparing antioxidant products or anti-inflammatory products and has a relatively high application value.

The invention discloses a culture method for hypoxia culture of umbilical cord mesenchymal stem cells, which comprises the following steps: hypoxia pre-adaptive culture: inoculating umbilical cord mesenchymal stem cells in a culture medium containing bFGF (basic fibroblast growth factor), glutathione, astragalus polysaccharide and salidroside, and transferring the umbilical cord mesenchymal stem cells into a 5% O2 environment after the umbilical cord mesenchymal stem cells are preliminarily adhered to the wall in a normal oxygen environment; performing low-oxygen enrichment culture: replacing a second culture medium containing astragalus polysaccharide, salidroside, D-ribose, sodium pyruvate and D-glucose, and promoting efficient cell proliferation under 2% O2; performing function strengthening culture: adding tanshinone IIA and GSK-269962A, inducing cells to secrete VEGF under 1% O2, and maintaining high dryness. According to the method, through the synergistic effect of the three-stage gradient oxygen concentration and the specific serum-free culture medium, the cell proliferation multiple is remarkably increased, the total apoptosis rate is reduced, VEGF secretion is promoted, the multidirectional differentiation potential is reserved, the culture method is standardized in operation, the serum-free culture medium is definite in component, and a high-quality stem cell culture scheme is provided for the field of regenerative medicine.

The present application relates to the field of microbiological technology, and particularly relates to a pathogenic bacterium causing root rot symptoms of red heart disease of Astragalus membranaceus and application thereof, the pathogenic bacterium is Fusarium sp. Fusarium sp. FUS-001-2025, preserved in China General Microbiological Culture Collection Center on March 16, 2026, with the preservation number of CGMCC No. 42529; it is determined to be a new recorded strain of Fusarium sp. through morphological and molecular identification, and the bactericide sensitivity determination shows that 25% silthiofam·prochloraz has the strongest inhibition effect, 25% bromothalonil, 50% azoxystrobin and 70% methylthiophanate have significant inhibition at high concentrations. The present application provides an important pathogenic bacterium resource for the pathogenic mechanism, disease resistance evaluation and development of control agents of red heart disease of Astragalus membranaceus.

The present application relates to the technical field of polysaccharide modification, and specifically discloses amino acid modified astragalus polysaccharide, a preparation method thereof and antibacterial application. The present application uses astragalus polysaccharide, formaldehyde and specific amino acids as raw materials, and prepares amino acid grafted modified astragalus polysaccharide through a Mannich reaction. The amino acid grafting site only occurs on the fifth carbon of the sugar ring. Not only does this retain the amino and carboxyl groups of the amino acid, so that the biological activity of the amino acid is retained, but also the active carboxyl group of the astragalus polysaccharide can be retained, so that the antibacterial property of the synthesized amino acid modified astragalus polysaccharide is significantly improved, and broad-spectrum antibacterial property can be achieved. The amino acid modified astragalus polysaccharide has excellent antibacterial activity on gram-positive bacteria and gram-negative bacteria, is a green new type of efficient antibacterial material, and is expected to become a substitute for antibiotics. The amino acid modified astragalus polysaccharide has important significance for solving the problems of increasing bacterial drug resistance and environmental accumulation caused by antibiotics, and has good application prospect.

This invention discloses a processing technology for antibody-enhancing probiotic feed, which includes raw material pretreatment, substrate preparation, sterilization, cooling, strain activation, aseptic inoculation, constant-temperature anaerobic fermentation, immune-enhancing compounding, filtration and homogenization, and aseptic filling and storage. The fermentation substrate liquid includes purified water, molasses, yeast extract, compound trace elements, and buffer salts. A compound microbial community composed of *Lactobacillus plantarum*, *Bacillus subtilis*, *Bifidobacterium*, and yeast is used for fermentation. The temperature is controlled at 35–39°C during fermentation, and intermittent stirring is employed. After fermentation, astragalus polysaccharide, echinacea extract, and trehalose are added for compounding. This invention reduces the loss of active ingredients by adding immune-enhancing components after fermentation, and improves the survival rate of probiotics and fermentation stability through intermittent stirring. The resulting liquid feed has a high live bacteria content and immune-enhancing effect.

The application relates to the field of astragalus extract technology, in particular to a preparation process of astragalus polysaccharide powder. The preparation process of the astragalus polysaccharide powder comprises the following steps: soaking astragalus medicinal materials in a soaking liquid, heating to extract astragalus polysaccharide and astragalus glycoside, separating liquid phase, concentrating the liquid phase to obtain concentrated liquid, adding a biological wrapping agent, spray drying, and obtaining astragalus polysaccharide powder; the soaking liquid comprises a co-crystal solvent and water; the biological wrapping agent can wrap the astragalus polysaccharide and the astragalus glycoside. The co-crystal solvent changes the crystal structure of the astragalus polysaccharide and the astragalus glycoside through non-covalent interaction, improves the solubility of the astragalus polysaccharide and the astragalus glycoside, and the soaking liquid heating extraction can significantly improve the extraction rate of the astragalus polysaccharide and the astragalus glycoside compared with pure water heating extraction. The biological wrapping agent is a substance that can be eaten by livestock and poultry.

The invention belongs to the technical field of microbial agents, and particularly relates to a microbial agent containing bacillus velezensis and application of the microbial agent to astragalus membranaceus. The invention discloses a microbial agent for astragalus membranaceus. The microbial agent is prepared by mixing bacillus velezensis powder, bacillus subtilis powder and bacillus pumilus powder according to the mass ratio of 1: (1-10): (1-5), the bacterium content of the bacillus velezensis powder, the bacillus subtilis powder and the bacillus pumilus powder is 0.2-0.5 billion cfu / g. The bacillus velezensis, the bacillus subtilis and the bacillus pumilus are fermented respectively, fermentation liquor is taken to be prepared into powder, and the powder is mixed according to a certain mass ratio to form the compound microbial agent, so that the compound microbial agent can improve the prevention and treatment effect on the radix astragali root knot nematode disease, is green and environment-friendly, can effectively overcome the defects of chemical agents, and has a good application prospect. Support is provided for biological prevention and control of the radix astragali root knot nematode disease, and meanwhile healthy growth of radix astragali plants can be guaranteed.

The present application belongs to the technical field of biological medicine, and particularly relates to a pharmaceutical composition for treating pulmonary fibrosis and a preparation method thereof. The composition comprises the following raw materials in parts by weight: 12-18 parts of Astragalus membranaceus, 6-12 parts of Ophiopogon japonicus, 4-10 parts of Poria cocos, 1-3 parts of Radix Glycyrrhizae, 10-16 parts of Salvia miltiorrhiza, 6-12 parts of Scutellaria baicalensis, 4-10 parts of Morus alba, 2-6 parts of Pericarpium Citri Reticulatae Viride, 1-4 parts of Sophora flavescens and 1-4 parts of Fritillaria cirrhosa. The present application is a three-phase and fixed-ratio compound of polysaccharides, phenolic acids and flavonoids. The polysaccharides are obtained by water extraction and alcohol precipitation, and are used as a mucosal retention adhesion carrier. The phenolic acids and flavonoids are extracted by low-degree ethanol refluxing, so as to ensure the structural integrity and maintain stability. The alkaloids are extracted by ethanol and then mildly salified, so as to reduce irritation and adsorption loss. The polysaccharides are then subjected to selective light fermentation to build a slightly acidic environment. In the compounding process, a buffer system is used to adjust pH, and cyclodextrin is used to stably bind the components. The three phases synergistically intervene in oxidation-inflammation-fibrosis.

The present invention discloses a type IV collagen detection kit and a preparation method thereof, relating to the technical field of in vitro diagnosis. The kit comprises a reagent R1 and a reagent R2, wherein the volume ratio of the reagent R1 to the reagent R2 is 3:1. The present invention improves the sensitivity and accuracy of detection while ensuring the stability and repeatability of the kit through a carefully designed reagent formula, in particular the precise proportion of the components in the reagent R1, such as ammonium chloride, sodium azide, and Brij‑35. In particular, the reagent R1 introduces a natural plant extract, astragalus polysaccharide, and a proteinase K inhibitor as key components. The unique preparation method and the activity-promoting effect on type IV collagen hydrolase significantly enhance the biological activity of the kit, making the detection results more reliable. In addition, the latex particles coated with two paired mouse monoclonal antibodies used in the reagent R2 have high specificity and affinity, further improving the accuracy and sensitivity of detection.

The invention discloses a preparation technology of astragalus polysaccharide camouflage monosaccharide, and relates to the technical field of biological product production, the preparation technology comprises the following steps: S1, extraction, S2, purification: carrying out purification treatment on astragalus polysaccharide extracted in the step 1, S3, degradation camouflage: dissolving the astragalus polysaccharide purified in the step 2 in a solvent, carrying out degradation treatment on the astragalus polysaccharide by adopting ultrasonic waves, and carrying out purification treatment on the astragalus polysaccharide to obtain the astragalus polysaccharide camouflage monosaccharide. A specific glucan structural unit in a polysaccharide chain is degraded and disguised into a monosaccharide or oligosaccharide structure; and S4, separating to obtain a product. Astragalus polysaccharide is directionally camouflaged as a monosaccharide / oligosaccharide structure, the recognition and uptake efficiency of astragalus polysaccharide by cancer cells is remarkably enhanced, so that the targeting of inducing apoptosis of cancer cells is improved, the structure can effectively activate and train immune cells such as dendritic cells and strengthen anti-tumor immune response, and meanwhile, the product can interfere with a metabolic pathway of cancer cells and reverse the drug resistance of cancer cells, so that the anti-tumor effect is improved. Nutrition supply is blocked to inhibit tumor growth, the production process is green and controllable, and good clinical transformation and industrialization prospects are achieved.

The invention relates to the technical field of extraction and purification of natural medicines, and discloses a preparation method of high-purity astragalus polysaccharide raw material powder, which comprises the following steps: hot water extraction: extracting astragalus root powder of 80-120 meshes for 2-3 times at 80-90 DEG C for 1.5-2.0 hours each time according to a solid-to-liquid ratio of (1: 10)-(1: 30), merging filtrates, and concentrating under reduced pressure until the volume is 1 / 3-1 / 5 of the original volume; deproteinizing and decoloring: adding neutral protease to act for 1-4 hours at the temperature of 45-55 DEG C and the pH value of 6.5-7.5, and inactivating at the temperature of 90 DEG C for 10 minutes; adding 0.5%-2.0% of cross-linked polyvinylpyrrolidone, performing contact for 10-20 minutes, and performing solid-liquid separation to obtain clear liquid; and two-phase distribution and post-treatment: adding polyethylene glycol 4000 and sodium dihydrogen phosphate / disodium hydrogen phosphate into the clear liquid. The invention aims to shorten the process, improve the yield and purity and reduce protein / polyphenol and salt / polymer residues under the condition of not using ion exchange resin.

The invention discloses a preparation method of a physical adsorption and biodegradation composite mildew removing agent. The preparation method comprises the following steps: preparing modified montmorillonite: modifying sodium montmorillonite by using hexadecyl trimethyl ammonium bromide; culturing a bacillus subtilis fermentation culture: culturing bacillus subtilis CICC20683 by adopting a two-step method of seed culture and fermentation culture, and collecting thalli; culturing a lactic acid bacteria fermentation culture: culturing lactic acid bacteria CICC6078 by adopting a two-step method of seed culture and fermentation culture, and collecting thalli; and composite preparation: uniformly mixing 30-50 parts by weight of modified montmorillonite, 10-20 parts by weight of yeast cell wall polysaccharide, 20-30 parts by weight of bacillus subtilis fermentation culture, 10-20 parts by weight of lactic acid bacteria fermentation culture, 5-10 parts by weight of astragalus polysaccharide and 3-5 parts by weight of vitamin C, carrying out vacuum drying at 40 DEG C until the moisture content is lower than 8%, and crushing to 80 meshes. The preparation method is simple in process and convenient to operate, the used raw materials and equipment are common industrial raw materials and equipment, the production cost is low, and the preparation method has a good market application prospect.

1. Name of the design product: Packaging box (Astragalus Polysaccharide Injection for Veterinary Use). 2. Use of the design product: Veterinary drug packaging. 3. Design key points of the design product: The pattern of the product. 4. Picture or photograph that best shows the design key points: Front view.

The invention discloses a Zhuang medicine composition for reversing radiotherapy resistance and a preparation method of the Zhuang medicine composition, and mainly relates to the technical field of Zhuang medicine compositions. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-30 parts of delavay knotweed herb, 10-30 parts of hedyotis diffusa, 8-15 parts of Chinese bulbophyllum, 10-20 parts of wild chrysanthemum flower, 10-20 parts of hairyvein agrimony, 10-20 parts of astragalus membranaceus, 10-30 parts of bighead atractylodes rhizome, 10-30 parts of crude dragon bone, 10-30 parts of stiff silkworm, 8-15 parts of cicada slough and 8-15 parts of honey-fried licorice root. On the basis of lung cancer radiotherapy, the self-prepared Zhuang medicine compound detoxifying and restoring decoction is matched for treatment, the synergistic interaction effect is achieved, meanwhile, the radiotherapy toxic and side effects can be effectively reduced, and the clinical treatment effect is stable and exact.

The invention provides a Babylonia areolata larva disease-resistant cultivation method based on immunostimulation, and aims to solve the problems of frequent larva diseases and low survival rate in intensive cultivation. The method comprises the following steps: selecting Babylonia areolata of Thailand and Hainan populations for reciprocal cross to obtain hybrid filial generations; in the larva stage, a compound immunologic stimulant compounded by astragalus polysaccharide, peptidoglycan and beta-glucan is adopted, the concentration is accurately regulated and controlled according to the early, middle and late stages of the daughter larvae and the creeping stage, and alternate induction is conducted through water splashing and bait mixing and feeding; when the larva shell length is 30-50mm, vibrio harveyi sublethal infection is used for enhancing immune memory, and environmental parameters such as water temperature and salinity are synchronously regulated and controlled. Tests show that the method can significantly improve the growth performance, immune enzyme activity and disease resistance of larvae, the survival rate of cultivation reaches 95% or above, the natural morbidity is lower than 6%, and technical support is provided for large-scale healthy cultivation of Babylonia areolata.

The invention relates to the technical field of feed additives, and discloses a Liaoning medicinal plant extract compound feed additive, which is prepared by the following steps: uniformly mixing an acanthopanax senticosus extract, a schisandra chinensis extract, an astragalus membranaceus extract, ginseng polysaccharide and ginsenoside to obtain a compound plant extract; stearic acid and soya bean lecithin are adopted to coat the composite plant extract to form lipid nanoparticles; and mixing the lipid nanoparticles with the composite carrier, and sieving to obtain the composite feed additive. The lipid nanoparticles are loaded on the composite carrier, so that the formed composite feed additive is not easily influenced by environmental factors such as light, heat and oxygen, has relatively high activity, improves the quality of feed and the appetite of bred livestock and poultry, is relatively high in bioavailability, and improves the meat growth speed of the bred livestock and poultry.

The active oligopeptide TDGLTSLD and the astragalus polysaccharide which can improve the resistance or the immunity or the growth capacity of animals are separated from the astragalus seedlings serving as a natural source, the feed containing the oligopeptide and the polysaccharide can effectively improve the immunity of the animals, the growth capacity such as the feed conversion ratio of the animals can be improved, and the feed has a wide application prospect.

The invention discloses a tobacco leaf fermentation anti-mildew method based on an astragalus membranaceus-honeysuckle compound extract and application of the tobacco leaf fermentation anti-mildew method. The method comprises the steps that astragalus membranaceus and honeysuckle with specific indexes are screened and mixed in proportion, then ultrasonic extraction is conducted through an ethanol-water solution, and the compound extract is obtained through purification; preparing the extract into a solution, spraying the solution to pre-balanced tobacco leaves, then regulating and controlling fermentation temperature and humidity and gas concentration in stages, and monitoring microorganism and physicochemical indexes until the tobacco leaves reach the standard. According to the tobacco leaf fermentation anti-mildew method, aspergillus niger is inhibited in a targeted mode (the inhibition rate is larger than 90%), lactic acid bacteria proliferation is promoted, and the tobacco leaf mildew rate is reduced to 0%; aroma substances such as solanesol are reserved, and sensory evaluation is improved by 20%; chemical preservatives are replaced, the problems of safety dispute and flavor damage are avoided, and cigarette production requirements are met.

The invention relates to an astragalus polysaccharide continuous quantitative feeding reaction device, and belongs to the field of quantitative feeding reaction devices.The astragalus polysaccharide continuous quantitative feeding reaction device comprises a reaction kettle, the reaction kettle is communicated with a feeding shell, a material receiving hopper is arranged in the feeding shell, the lower end of the material receiving hopper is communicated with a material receiving pipe, and an auger is arranged in the material receiving pipe; a quantifying assembly is arranged at the lower end of the material receiving pipe and is used for separating the material receiving pipe from the reaction kettle. The method has the effect of conveniently controlling the dosage of the astragalus polysaccharide in the reaction process.

The invention discloses milkvetch root bean curd and a preparation method thereof, and relates to the field of food processing, and the milkvetch root bean curd comprises the following raw materials by weight: 500 grams of soybeans, 15 grams of milkvetch roots, 10 grams of magnesium chloride and water. According to the milkvetch root bean curd, through the milkvetch root and magnesium chloride synergistic solidification technology and the double soaking and mixed pulping technology, fusion of effective components (milkvetch root polysaccharide and saponin) of milkvetch roots and soybean protein is achieved, and the health-care function and taste of the bean curd are improved.

This application relates to a CCHG / APS composite hydrogel, its preparation method, and its application. A method for preparing the CCHG / APS composite hydrogel includes adding a chitosan solution dropwise to a carbomer solution, mixing, then adding an astragalus polysaccharide solution, adjusting the pH to 6.5-7.2, and performing cross-linking to obtain the CCHG / APS composite hydrogel. Firstly, performance characterization of the CCHG / APS hydrogel shows that it exhibits a unique loose and porous structure with good stability. Simultaneously, its rheological properties, swelling properties, and water retention capacity are all within suitable ranges, and it demonstrates excellent antibacterial properties, providing a favorable microenvironment for wound healing. In animal experiments, the CCHG / APS hydrogel exhibited a significant healing-promoting effect, and no obvious in vivo toxicity was observed throughout the experiment, confirming its good biocompatibility.

The invention provides radix astragali homogeneous polysaccharide as well as a preparation method and application thereof, and belongs to the field of separation and purification of natural products. The radix astragali homogeneous polysaccharide is composed of glucose and galactose, and the molecular weight of the radix astragali homogeneous polysaccharide is 1900-2200 Da. The preparation method comprises the following steps: performing water extraction and alcohol precipitation on astragalus membranaceus to obtain astragalus membranaceus crude polysaccharide, and performing column chromatography elution on the astragalus membranaceus crude polysaccharide to obtain the homogeneous astragalus membranaceus polysaccharide with the molecular weight of 1900-2200Da. The radix astragali homogeneous polysaccharide has excellent effects of resisting inflammation, regulating intestinal flora, regulating intestinal absorption function, scavenging free radicals, regulating immunity, improving prebiotic activity and resisting pulmonary fibrosis.

The invention relates to an immunoregulation, antioxidation and sleep-aiding compound composition and a preparation method thereof.The preparation method comprises the steps that astragalus membranaceus and acanthopanax senticosus are treated through a subcritical water extraction technology, the extraction conditions are that the temperature is 120 DEG C and the pressure is 2 MPa, and an extract rich in saponin and polysaccharide is obtained; chinese wolfberry fruits and cranberries are treated by adopting a composite enzymolysis technology, and cellulase and pectinase are used for enzymolysis, so that the dissolution rate of polysaccharides is increased; the ganoderma lucidum spore powder is subjected to superfine grinding and low-temperature wall breaking treatment, and the wall breaking rate is larger than or equal to 98% According to the immunoregulation, anti-oxidation and sleep-aiding compound composition and the preparation method thereof, the synergistic effect of three effects of immunoregulation, anti-oxidation and sleep improvement is achieved, and all the active ingredients achieve synergistic interaction through different mechanisms: the acanthopanax senticosus polysaccharide and the ganoderma lucidum beta-glucan activate inherent immunity, the astragaloside and the lycium barbarum polysaccharide enhance adaptive immunity, and the anti-oxidation and sleep-aiding compound composition has the effects of improving immunity, resisting oxidation and aiding sleep. While the sleep is improved, the cortisol level is reduced, and the vicious circle of stress, insomnia and immunity decline is blocked.

The application provides a medicine composition for treating hepatobiliary diseases and a preparation method thereof, and the active ingredients are composed of a compound shown in formula (I) and Astragalus membranaceus and Saussurea involucrata extract, the weight ratio of the compound shown in formula (I) to the Astragalus membranaceus and Saussurea involucrata extract is 1: (1.5-2.0) by weight; compared with the prior art, the medicine composition of the application has a synergistic effect on hepatobiliary diseases, especially gallstones, and the effect is remarkable.