Donkey-hide gelatin micro-pills and preparation method thereof

A technology for Ejiao pellets and Ejiao, which is applied in the field of medicine and food, can solve the problems of low bioavailability, long disintegration time, gastric mucosal irritation, etc., and achieves the effects of high bioavailability, good effectiveness and reducing the number of times of administration.

Inactive Publication Date: 2009-06-17
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Ejiao products are favored by consumers. Most of these products are ordinary tablets, soft capsules, oral liquids and capsules, but the disintegration time of the above dosage forms is long; they disintegrate at a certain point in the body. Solution, has certain irritation to gastric mucosa; low bioavailability and other disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take the ingredients for the following recipe:

[0035] donkey-hide gelatin 25g Methylcellulose 73g Polyvinylpyrrolidone 2g

[0036] Prepare pellet formulations as follows:

[0037] (1) Take the donkey-hide gelatin of the above-mentioned formula quantity and add methyl cellulose, pulverize to micronized level with a ball mill, and mix;

[0038] (2) polyvinylpyrrolidone is dissolved in 65% ethanol solution;

[0039] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0041] Take the following ingredients for the recipe

[0042] donkey-hide gelatin 50g sucrose 28g starch 22g

[0043] Prepare pellet formulations as follows:

[0044] (1) Add the donkey-hide gelatin in the above-mentioned formula amount to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0045](2) With part of the sucrose as the core, the remaining part of the sucrose is made into syrup to play a binding role;

[0046] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0048] Take the following ingredients for the recipe

[0049] donkey-hide gelatin 70g starch 25g Hydroxypropylmethylcellulose 5g

[0050] Prepare the pellet preparation according to the following method: donkey-hide gelatin

[0051] (1) Add the donkey-hide gelatin in the above-mentioned formula amount to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0052] (2) hydroxypropyl methylcellulose is dissolved in an appropriate amount of water;

[0053] (3) The centrifugal-fluidized pelletizing method is used to make pellets.

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Abstract

The invention discloses a pellet formulation of donkey-hide gelatin which is prepared by donkey-hide gelatin and pharmaceutical excipients, wherein the pharmaceutical excipients are excipient and adhesive. In the pellet formulation, the weight percentage of the donkey-hide gelatin is 20-80 %, the weight percentage of the excipient is 20-80%, and the weight percentage of the adhesive is 1-5%. The pellet formulation can be made into sustained release formulation or enteric-coated formulation according to the requirements. The inventive pellet formulation has high dissolution rate and bioavailability, easy and convenient preparation method, and easy operation.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of donkey-hide gelatin and a preparation method thereof. Background technique: [0002] Donkey-hide gelatin, also known as pot cover glue and donkey skin glue, is a glue made from donkey skin. According to traditional Chinese medicine, donkey-hide gelatin is sweet and flat in nature, and has the effects of nourishing yin, nourishing blood, and preventing miscarriage. According to research, donkey-hide gelatin contains a variety of proteins, amino acids, calcium, etc., which can promote the production of red blood cells and red blood cells, and promote rapid hematopoiesis in the human body; it can improve nutritional anemia, anemia, improve calcium balance in the body, increase calcium absorption, and make blood calcium Improve; can prevent the oxidative damage of vitamin E in food, prevent progressive muscular dystrophy, improve the conversion rate of hu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/36A61K9/16A61P3/14A61P7/06A61P15/00
Inventor 于明
Owner JF PHARMALAND TECH DEV
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