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Micro-pills containing apple polyphenol, and preparation method of micro-pills
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A technology of apple polyphenols and pellets, applied in the field of medicine and food, to achieve the effect of rapid onset and high bioavailability
Inactive Publication Date: 2015-06-03
JF PHARMALAND TECH DEV
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Abstract
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Problems solved by technology
[0004] At present, products related to apple polyphenols are well received by consumers. These products are basically ordinary tablets and capsules, but the above dosage forms have disintegration Long time; Disintegrate at a certain point in the body, which has certain irritation to gastric mucosa; Low bioavailability and other disadvantages
Method used
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Embodiment 1
[0033] Take the following ingredients for the recipe
[0034] Apple polyphenols 15g Crystalline Cellulose 80g Hydroxypropylmethylcellulose 4g
[0035] Prepare pellet formulations as follows:
[0036] (1) Take the apple polyphenols in the amount of the above formula, add microcrystalline cellulose, pulverize it to a micronized level with a ball mill, and mix well;
[0037] (2) Dissolve hydroxypropyl methylcellulose in 75% ethanol solution;
[0038] (3) Micro-pills are made by extrusion-spheronization into pellets.
[0039]
Embodiment 2
[0041] Take the following ingredients for the recipe
[0042] Apple polyphenols 10g starch 82g Polyvinylpyrrolidone 5g
[0043] Prepare pellet formulations as follows:
[0044] (1) Take the apple polyphenols in the amount of the above formula, add starch, grind to micronized level with a ball mill, and mix well;
[0045] (2) Dissolve the adhesive polyvinylpyrrolidone in water;
[0046] (3) Micro-pills are made by pan-pill method.
Embodiment 3
[0048] Take the following ingredients for the recipe
[0049] Apple polyphenols 8g sucrose 49g starch 34g Polyvinylpyrrolidone 4g
[0050] Prepare pellet formulations as follows:
[0051] (1) Take the apple polyphenols in the amount of the above formula, add sucrose and starch, grind to micronized level with a ball mill, and mix well;
[0052] (2) Dissolve polyvinylpyrrolidone in an appropriate amount of water;
[0053] (3) Using the centrifugal-fluidized pelleting method to make pellets.
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Abstract
The invention provides a micro-pill preparation containing apple polyphenol. The micro-pill preparation is prepared from apple polyphenol and pharmaceutical adjuvants, and is characterized in that the pharmaceutical adjuvants comprise an excipient and a bonding agent. The micro-pill preparation comprises 5-20% of apple polyphenol, 70-85% of excipient and 1-5% of a bonding agent by weight percent. The micro-pill preparation is high in dissolution rate and bioavailability, and a preparation method of the micro-pill preparation is simple, convenient and easy to operate.
Description
[0001] Technical field: [0002] The invention relates to the technical field of medicine and food, in particular to a pellet made of apple polyphenols and a preparation method thereof. [0003] Background technique: [0004] At present, products related to apple polyphenols are well received by consumers. These products are basically ordinary tablets and capsules, but the above-mentioned dosage forms have a long disintegration time; The mucous membrane is irritating to a certain extent; the bioavailability is low and other disadvantages. Based on the above problems, we introduced the rapid development of micropill technology in the field of medicine to the field of food, and made this product into a compound micropill product with controllable release in the body and high bioavailability, so as to better meet the needs of the general public. consumer needs. [0005] Pharmaceutical excipients such as excipients, binders, porogens, disintegrants, and plasticizers are ge...
Claims
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Application Information
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