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Desertliving cistanche herb extract pellet and preparation method thereof

A technology of cistanche extract and pellets, which is applied in the field of medicine and food, can solve the problems of long disintegration time, irritation of gastric mucosa, and low bioavailability, and achieve good effectiveness, reduced total dose, and high bioavailability Effect

Inactive Publication Date: 2009-06-03
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are not many Cistanche extract products on the market, but they are all ordinary tablets and capsules. The above-mentioned dosage forms have a long disintegration time and disintegrate at a certain point in the body, which is irritating to the gastric mucosa and biological Disadvantages such as low utilization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Take the following ingredients for the recipe

[0036] Cistanche Extract 10g microcrystalline cellulose 87g Hydroxypropylmethylcellulose 3g

[0037] Prepare pellet formulations as follows:

[0038] (1) Add the Cistanche deserticola extract of the above-mentioned formula amount to microcrystalline cellulose, pulverize it to a micronized level with a ball mill, and mix well;

[0039] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0040] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0042] Take the following ingredients for the recipe

[0043] Cistanche Extract 40g sucrose 55g Polyvinylpyrrolidone 5g

[0044]Prepare pellet formulations as follows:

[0045] (1) Take the Cistanche deserticola extract of the above-mentioned formula amount and add sucrose, pulverize it to a micronized level with a ball mill, and mix well;

[0046] (2) polyvinylpyrrolidone is dissolved in water;

[0047] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0049] Take the following ingredients for the recipe

[0050] Cistanche Extract 60g sucrose 25g starch 11g Polyvinylpyrrolidone

Polyvinylpyrrolidone 4g

[0051] Prepare pellet formulations as follows:

[0052] (1) Take the Cistanche deserticola extract of the above formula amount, add sucrose and starch, pulverize it to a micronized level with a ball mill, and mix well;

[0053] (2) polyvinylpyrrolidone is dissolved in water;

[0054] (3) The centrifugal-fluidized pelletizing method is used to make pellets.

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PUM

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Abstract

The invention provides a desertliving cistanche herb extract pellet preparation composed of desertliving cistanche herb extract and medical supplementary materials. The desertliving cistanche herb extract pellet preparation is characterized in that the medical supplementary materials are excipients and binders; and in the pellet preparation, the content of desertliving cistanche herb extract 1-80 percent by weight, the content of excipients is 20-99 percent by weight, and the content of binders is 1-5 percent by weight. The pellet preparation has high dissolution rate and high bioavailability, and the preparation method is simple, convenient and easy for operation.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of Cistanche deserticola extract and a preparation method thereof. Background technique: [0002] Cistanche is the succulent stem of Cistanche deserticola, a plant in the family Danaceae, which has the functions of nourishing the kidney and yang, moistening the intestines and laxative. It is clinically used for kidney deficiency impotence, nocturnal emission, premature ejaculation, cold pain in the waist and knees, weakness of muscles and bones, dryness of the intestine and constipation. [0003] Cistanche tubulosa is also a plant of the family Danaceae. Its efficacy is similar to that of Cistanche. It is often used as Cistanche. Therefore, the extract of Cistanche here includes the extract of Cistanche tubulosa, which has the functions of nourishing the kidney, improving immunity, anti-aging and improving memory. And so on. Cistanche deserticola is kno...

Claims

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Application Information

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IPC IPC(8): A61K36/64A61K9/16A61P1/10A61P15/10A61K135/00
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV
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