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Pearl powder micro-pills and preparation method thereof

A technology of pearl powder and pellets, which is applied in the field of medicine and food, can solve the problems of long disintegration time, low bioavailability, irritation of gastric mucosa, etc., and achieve good effectiveness, high bioavailability, and reduce the number of times of taking

Inactive Publication Date: 2009-06-17
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently developed pearl powder products are basically ordinary tablets and capsules, but the above-mentioned dosage forms have a long disintegration time; they disintegrate at a certain point in the body, which is irritating to the gastric mucosa; the bioavailability is low, etc. shortcoming

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take the following ingredients for the recipe

[0035] Pearl powder 20g starch 87g Hydroxypropylmethylcellulose 3g

[0036] Prepare pellet formulations as follows:

[0037] (1) Add the pearl powder of the above-mentioned formula amount to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0038] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0039] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0041] Take the following ingredients for the recipe

[0042] Pearl powder 50g starch 46g Polyvinylpyrrolidone 4g

[0043] Prepare pellet formulations as follows:

[0044] (1) Add the pearl powder of the above-mentioned formula amount to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0045] (2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0046] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0048] Take the following ingredients for the recipe

[0049] Pearl powder 70g Crystalline Cellulose 28g Hydroxypropylmethylcellulose 2g

[0050] Prepare pellet formulations as follows:

[0051] (1) Take the pearl powder of the above-mentioned formula amount and add the crystal cellulose, pulverize it to the micronization level with a ball mill, and mix well;

[0052] (2) hydroxypropyl methylcellulose is dissolved in an appropriate amount of 70% ethanol;

[0053] (3) The centrifugal-fluidized pelletizing method is used to make pellets.

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Abstract

The invention discloses a pellet formulation of pearl powder which is prepared by pearl powder and pharmaceutical excipients, wherein the pharmaceutical excipients are excipient and adhesive. In the pellet formulation, the weight percentage of the pearl powder is 5-80%, the weight percentage of the excipient is 20-95%, and the weight percentage of the adhesive is 1-5%. The inventive pellet formulation has high dissolution rate and bioavailability, easy and convenient preparation method, and easy operation.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a micropill made of pearl powder and a preparation method thereof. Background technique: [0002] The medicinal use of pearls has a history of more than 2,000 years in China. The medical book "Famous Doctors" in the Three Kingdoms period, the "Compendium of Materia Medica" in the Liang Dynasty, the "Haiyao Materia Medica" in the Tang Dynasty, the "Kaibao Materia Medica" in the Song Dynasty, the "Compendium of Materia Medica" in the Ming Dynasty, and the "Lei Gong Medicine Nature Fu" in the Qing Dynasty. " and other 19 kinds of medical ancient books have clear records on the curative effect of pearls. [0003] Tao Hongjing of the Liang Dynasty said in the "Compendium of Materia Medica" that pearls "have the functions of treating eyesight, skin nebula, and stopping diarrhea". The "Haiyao Materia Medica" of the Tang Dynasty believes that pearls can improve eyesight, eli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61K9/16A61P3/02A61P17/16A61P25/20A61P27/02A61P37/04A61P39/06A61K35/618
Inventor 李军
Owner JF PHARMALAND TECH DEV
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