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68results about How to "Avoid photolysis" patented technology

Preparation method of smellless coated enrofloxacin preparation

The invention relates to an antibacterial drug for livestock, particularly a preparation method of a smellless coated enrofloxacin preparation. The antibacterial drug for livestock is prepared from the following raw materials in percentage by weight: 5-15% of enrofloxacin, 0.01-0.1% of polyacrylic resin II, 1-10% of polyethyleneglycol, 50-70% of stearic acid, 25-45% of beta-cyclodextrin, 50-60% of water and 30-50% of anhydrous ethanol. The preparation method comprises the following steps: evenly stirring beta-cyclodextrin and water, adding enrofloxacin and polyethyleneglycol, stirring, drying the obtained inclusion compound, and pulverizing; heating stearic acid to a transparent liquid, adding the pulverized inclusion compound, and carrying out spray freeze-drying to obtain microcapsule particles; and finally, dissolving a hydrophobic material in anhydrous ethanol, and carrying out bottom-spray coating on the microcapsule particles to obtain the finished product. After the enrofloxacin is coated, the bitterness is covered up, so that the enrofloxacin does not stimulate the stomach, thereby preventing the ingesting animals from gastrospasm and nausea, and thus, the enrofloxacin can be orally dosed to pigs; the multilayer coating prevents the enrofloxacin from composition under the light, and can be mixed in a wet state; and the invention is convenient for production, and fully displays the powerful bactericidal action of enrofloxacin.
Owner:ZHEJIANG KING TECHINA TECH

Liquid vitamin and manufacture method thereof

The invention discloses liquid vitamin and a manufacture method thereof. The liquid vitamin is produced by 1.5% to 3.0% of fat soluble vitamin, 2.5% to 5.0% of water soluble vitamin, 0.02% to 0.05 % of fat soluble vitamin antioxidant formed by butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), gallic acid propyl ester or arbitrary combination of BHA, BHT and gallic acid propyl ester, 0.05% to 0.1% of water soluble vitamin antioxidant composed of mercaptoacetic acid and / or 2-mercaptoethanol, 0.005% to 0.05 % of antioxidant synergist composed of citric acid, ethylene diamine tetraacetic acid (EDTA)-2Na, erythorbic acid or arbitrary combination of citric acid, EDTA-2Na and erythorbic acid, 0.2% to 1% of preservative formed by methylparaben, propylparaben, benzyl alcohol or arbitrary combination of methylparaben, propylparaben and benzyl alcohol, 15% to 30% of emulsifier composed of twain and / or OP-10 and 60.8 % to 80.725% of infusion water. The liquid vitamin is produced in a good manufacturing practice (GMP) ten-thousand-stage clean workshop under the situation that the illumination intensity of the workshop is smaller than 20Lux and temperature of the workshop is controlled between 22 DEG C to 25 DEG C. The fat soluble vitamin antioxidant and the water soluble vitamin antioxidant in the liquid vitamin can uniformly and stably coexist in the same solution and are long in storage time.
Owner:BAODING JIZHONG PHARMA

Preparation method of traditional Chinese medicine composition for treating advanced non-small cell lung cancers

The invention discloses a preparation method of a traditional Chinese medicine composition for treating advanced non-small cell lung cancers. The method comprises the following steps of: 1. taking root of glaucescent fissistigma, barbated skullcup herb, radix astragali, sanqi and platycodon root; 2. removing impurities from sanqi and washing, drying, grinding, sieving and sterilizing sanqi, removing impurities from barbated skullcup herb and washing and cutting barbated skullcup herb into segments, removing impurities from glaucescent fissistigma, radix astragali and platycodon root and washing, moistening and slicing glaucescent fissistigma, radix astragali and platycodon root; 3. mixing barbated skullcup herb, glaucescent fissistigma, radix astragali and platycodon root and then adding water to soak the medicines, decocting the medicines and filtering the decoction; 4. adding water to the medicine dregs, decocting the medicine dregs, filtering the decoction, mixing the filtrate and concentrating the filtrate into thick paste under reduced pressure; 5. adding sanqi to the thick paste, mixing the medicines uniformly and then drying the mixture under reduced pressure, grinding the dried mixture and sieving the powder to obtain dry paste powder; and 6. capsulizing the dry paste powder to obtain a capsule, or adding dextrin and magnesium stearate to the dry paste powder, mixing the materials uniformly, granulating the mixture, drying the granules under reduced pressure, tabletting the dried granules and sugarcoating, thus obtaining a tablet. The preparation method has the advantages that the anticancer active ingredients in the traditional Chinese medicine are fully extracted and the transfer rates of the anticancer active ingredients are above 90%.
Owner:杨凌无为制药集团有限公司

Pellet type pantoprazole sodium enteric capsule and preparation method thereof

The invention discloses a pellet type pantoprazole sodium enteric capsule and a preparation method thereof. The pellet type pantoprazole sodium enteric capsule is a sustained-release preparation composed of a capsule shell and uniformly mixed pantoprazole sodium pellets held in the capsule shell; the pantoprazole sodium pellet from inside to outside in turn comprises a blank pellet core, a main drug layer, an isolation layer and an enteric layer, wherein the weight of the main drug layer is 14-55% of that of the blank pellet core, the weight of the isolation layer is 9-10% of that of the total weight of the blank pellet core and the main drug layer, the weight of the enteric layer is 28-32% of that of the total weight of the blank pellet core, the main drug layer and the isolation layer; 40-60% of that of the pantoprazole sodium pellet is coated with a pigmented layer on the outside of the enteric layer; the weight of the pigmented layer is 0.5-1% of that of the total weight of the blank pellet core, the main drug layer, the isolation layer and the enteric layer; the diameter of the blank pellet core is 0.8-1.0 mm; the granularity of the pantoprazole sodium pellet is 14-20 mesh; each capsule contains 20-40 mg of the pantoprazole sodium. The pellet type pantoprazole sodium enteric capsule has the advantages of acidproof, rapid release and stable.
Owner:ZHEJIANG CHANGDIAN PHARMA +1

Pesticide nano preparation and preparation method thereof

The invention provides a pesticide nano preparation and a preparation method thereof, and belongs to the technical field of pesticide preparations. The preparation method of the pesticide nano preparation provided by the invention comprises the following steps: dissolving a pesticide in an organic solvent, adding the obtained pesticide solution into water, and carrying out ultrasonic treatment toobtain a pesticide nano particle dispersion liquid; mixing the pesticide nanoparticle dispersion liquid, a dopamine hydrochloride aqueous solution and a Tris-HCl buffer solution to enable the pH valueof the obtained mixed material liquid to be 7.5-9.5, and then performing polymerization reaction to obtain a polymerization product system; and dialyzing and drying the polymerization product systemin sequence to obtain the pesticide nano preparation. According to the invention, dopamine hydrochloride in-situ polymerization is utilized to form a polydopamine shell on the surfaces of the pesticide nanoparticles, and the polydopamine shell can well absorb light, has a protective effect on the pesticide and avoids photolysis of the pesticide. Meanwhile, the method provided by the invention is simple and convenient to operate, low in cost, good in repeatability, green and environment-friendly.
Owner:GUANGDONG ACAD OF SCI INST OF BIOENGINEERING

Preparation method of Chinese medicinal tablets and capsules for tonifying kidney and strengthening yang

The invention discloses a preparation method of Chinese medicinal tablets and capsules for tonifying kidney and strengthening yang. The method comprises the following steps of: 1, weighing 150-250 parts by weight of fructus rosae laevigatae, 30-100 parts by weight of gecko, 500-600 parts by weight of epimedium herb, 30-100 parts by weight of semen allii tuberose and 200-300 parts by weight of dogwood; 2, pulverizing 52.5 parts by weight of gecko and 52.5 parts by weight of semen allii tuberose into fine powder, and pulverizing the remaining gecko and semen allii tuberose into coarse powder; 3, decocting the coarse powder, the fructus rosae laevigatae, the epimedium herb and the dogwood twice, filtering and combining filtrate and concentrating to thick paste; and 4, adding the fine powder into the thick paste to prepare the Chinese medicinal tablets and capsules for tonifying kidney and strengthening yang. According to the preparation method provided by the invention, the transfer rates for active ingredients of the medicaments are that: the transfer rate of rosa lacvigata michx polysaccharide reaches 98.6 percent, the transfer rate of icariin reaches 96.7 percent and the transfer rate of loganin reaches 95.8 percent; the transfer rates are obviously higher than those in the conventional method; meanwhile, the leaching of the inactive ingredients is reduced; the pharmaceutical effect is improved; and the cost is reduced.
Owner:杨凌无为制药集团有限公司

Pellet type omeprazole enteric capsule and preparation method thereof

The invention discloses a pellet type omeprazole enteric capsule and a preparation method thereof. The pellet type omeprazole enteric capsule is a sustained-release preparation, and is composed of a capsule shell and evenly mixed omeprazole pellets received in the capsule shell; each omeprazole pellet is composed of a blank pill core, a main drug layer, an isolation layer and an enteric layer in order from inside to outside, wherein the weight of the main drug layer accounts for 15-60% of that of the blank pill core, the weight of the isolation layer accounts for 10% of the total weight of the blank pill core and the main drug layer, the weight of the enteric layer accounts for 28-32% of the total weight of the blank pill core, the main drug layer and the isolation layer; besides, the enteric layers of 40-60% of omeprazole pellets are further coated with pigment layers; the weight of the pigment layer accounts for 0.5-1% of the total weight of the blank pill core, the main drug layer, the isolation layer and the enteric layer; the diameters of the blank pill cores are 0.8-1.0mm; the granularity of the omeprazole pellets is 14-20 meshes; each capsule contains 15-30mg of omeprazole. The pellet type omeprazole enteric capsule has the advantages of good acid resistance, sufficient active ingredient release without delay, good stability and the like.
Owner:ZHEJIANG CHANGDIAN PHARMA +1

a dispensing device

ActiveCN111332505BEfficient deliveryAvoid the process of repeatedly opening medicine tanks for dispensing operationsSolid materialPharmaceutical drugDispensing medications
The invention discloses a medicine dispensing device, the structure of which comprises a cylinder body, the lower end surface of the cylinder body is fixedly provided with a support foot, the support foot is a support foot structure, and a cylinder inner chamber with an opening facing downward is arranged in the cylinder body. The end wall of the inner cavity of the cylinder is connected with a plurality of clamping inner cavities. The clamping inner cavities are arranged in a circular array in the horizontal direction, and the clamping inner cavities are distributed in a linear array in the vertical direction. One side of the inner cavity is provided with a drug ejection and preparation device located on the outer surface of the cylinder for loading and automatically pushing out the tablets. This equipment adopts the design of the drug ejection and preparation device, so that the equipment can load and protect various types of tablets. , and according to the actual needs of the personnel, the internal tablet delivery structure of the equipment can be used to work, so that the tablets can be efficiently thrown out in the equipment, so as to realize the preparation of the tablets at the same time, avoiding the process of personnel repeatedly opening the medicine tank for dispensing operations.
Owner:ZHEJIANG COLLEGE OF CONSTR
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